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Abstract:

We have postulated that metabolic oxidation could be the source of signs and symptoms of hyperthyroidism. The present study was designed to evaluate urinary malondialdehyde levels in Graves' disease and compare this oxidative stress biomarker with the clinical evolution of patients suffering this illness. We evaluated the concentration of urinary and serum malondialdehyde (MDA) in 36 patients with Graves' disease. Patients were treated with the antithyroid drug methimazole (MMI; Group A) or antioxidant mixture (200 mg vitamin E, 3 mg β-carotene, 250 mg vitamin C, 1 mg Cu, 7.5 mg Zn, 1.5 mg Mn, and 15 μg Se; Group B). MDA concentrations were higher in hyperthyroid patients compared to euthyroid controls, and a positive correlation was observed between serum and urinary MDA levels. Group A decreased urinary MDA to control values. There was a positive correlation between the clinical score and the heart rate of patients with urinary MDA before and during the treatment with MMI (Group A). Similar results were observed after treatment with the antioxidant mixture. Urinary MDA might be a good parameter in the follow-up of patients during MMI treatment. We proposed that oxidative stress correlates with signs and symptoms of hyperthyroidism. © 2004 Published by Elsevier B.V.

Registro:

Documento: Artículo
Título:Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
Autor:Guerra, L.N.; Ríos De Molina, M.D.C.; Miler, E.A.; Moiguer, S.; Karner, M.; Burdman, J.A.
Filiación:Endocrinology Unit, Hospital Israelita EZRAH, Buenos Aires, Argentina, Argentina
Departmento de Quím. Biol., Fac. de Ciencias Exactas Y Naturales, Univ. Buenos Aires, Intendente G., Argentina
Universidad Abierta Interamericana, Hospital Israelita, Terrada 1164, Buenos Aires, A., Argentina
Hospital Israelita, Terrada 1164, (1416) Buenos Aires, Argentina., Argentina
Palabras clave:Hyperthyroidism; Malondialdehyde; Methimazole (MMI); antioxidant; malonaldehyde; thiamazole; adult; antioxidant activity; article; clinical article; comparative study; controlled study; correlation analysis; evaluation; female; Graves disease; heart rate; human; hyperthyroidism; male; oxidative stress; parameter; priority journal; Adult; Antioxidants; Double-Blind Method; Female; Follow-Up Studies; Graves Disease; Heart Rate; Humans; Male; Malondialdehyde; Methimazole; Middle Aged; Oxidative Stress
Año:2005
Volumen:352
Número:1-2
Página de inicio:115
Página de fin:120
DOI: http://dx.doi.org/10.1016/j.cccn.2004.08.020
Título revista:Clinica Chimica Acta
Título revista abreviado:Clin. Chim. Acta
ISSN:00098981
CODEN:CCATA
CAS:malonaldehyde, 542-78-9; thiamazole, 60-56-0; Antioxidants; Malondialdehyde, 542-78-9; Methimazole, 60-56-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v352_n1-2_p115_Guerra

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Citas:

---------- APA ----------
Guerra, L.N., Ríos De Molina, M.D.C., Miler, E.A., Moiguer, S., Karner, M. & Burdman, J.A. (2005) . Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels. Clinica Chimica Acta, 352(1-2), 115-120.
http://dx.doi.org/10.1016/j.cccn.2004.08.020
---------- CHICAGO ----------
Guerra, L.N., Ríos De Molina, M.D.C., Miler, E.A., Moiguer, S., Karner, M., Burdman, J.A. "Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels" . Clinica Chimica Acta 352, no. 1-2 (2005) : 115-120.
http://dx.doi.org/10.1016/j.cccn.2004.08.020
---------- MLA ----------
Guerra, L.N., Ríos De Molina, M.D.C., Miler, E.A., Moiguer, S., Karner, M., Burdman, J.A. "Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels" . Clinica Chimica Acta, vol. 352, no. 1-2, 2005, pp. 115-120.
http://dx.doi.org/10.1016/j.cccn.2004.08.020
---------- VANCOUVER ----------
Guerra, L.N., Ríos De Molina, M.D.C., Miler, E.A., Moiguer, S., Karner, M., Burdman, J.A. Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels. Clin. Chim. Acta. 2005;352(1-2):115-120.
http://dx.doi.org/10.1016/j.cccn.2004.08.020