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Abstract:

Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, and their absorption spectra and melting points were determined. It was found that the relative excretory pattern was: uroporphyrin > coproporphyrin > phyriaporphyrins > 5-COOH porphyrin > 6-COOH porphyrin. By chemical decarboxylation, all these porphyrins were found to be the type III isomer with only traces of uroporphyrin I and 5-COOH porphyrin I. The predominant porphyrins in the liver were uroporphyrin III and phyriaporphyrin. These findings were compared with those reported in humans intoxicated with the same chemical and with those in patients with hepatic porphyria cutanea tarda. The main differences among these groups were in the isomeric composition of the uroporphyrin, 5-COOH porphyrin and coproporphyrin. Porphyria induced in rats by hexachlorobenzene appears to provide a useful experimental approach for the study of the metabolic changes involved in human porphyria. © 1970.

Registro:

Documento: Artículo
Título:Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
Autor:de Viale, L.C.S.M.; Viale, A.A.; Nacht, S.; Grinstein, M.
Filiación:Departamento de Química Biológica, Orientatión Química Biológica I. Facultad de Ciencias Exactas y N aturales, Universidad de Buenos Aires, Argentina
Palabras clave:benzene derivative; chlorine; insecticide; lindane; porphyrin; animal; article; chromatography; female; human; iatrogenic disease; male; metabolism; microphotography; paper chromatography; porphyria; rat; spectrophotometry; urine; Animal; Benzene Derivatives; Chlorine; Chromatography; Chromatography, Paper; Female; Human; Insecticides, Botanical; Lindane; Male; Photomicrography; Porphyria; Porphyrins; Rats; Spectrophotometry
Año:1970
Volumen:28
Número:1
Página de inicio:13
Página de fin:23
DOI: http://dx.doi.org/10.1016/0009-8981(70)90155-5
Título revista:Clinica Chimica Acta
Título revista abreviado:Clin. Chim. Acta
ISSN:00098981
CODEN:CCATA
CAS:chlorine, 13981-72-1, 7782-50-5; lindane, 58-89-9; porphyrin, 24869-67-8; Benzene Derivatives; Chlorine, 7782-50-5; Insecticides, Botanical; Lindane, 58-89-9; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v28_n1_p13_deViale

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Citas:

---------- APA ----------
de Viale, L.C.S.M., Viale, A.A., Nacht, S. & Grinstein, M. (1970) . Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine. Clinica Chimica Acta, 28(1), 13-23.
http://dx.doi.org/10.1016/0009-8981(70)90155-5
---------- CHICAGO ----------
de Viale, L.C.S.M., Viale, A.A., Nacht, S., Grinstein, M. "Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine" . Clinica Chimica Acta 28, no. 1 (1970) : 13-23.
http://dx.doi.org/10.1016/0009-8981(70)90155-5
---------- MLA ----------
de Viale, L.C.S.M., Viale, A.A., Nacht, S., Grinstein, M. "Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine" . Clinica Chimica Acta, vol. 28, no. 1, 1970, pp. 13-23.
http://dx.doi.org/10.1016/0009-8981(70)90155-5
---------- VANCOUVER ----------
de Viale, L.C.S.M., Viale, A.A., Nacht, S., Grinstein, M. Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine. Clin. Chim. Acta. 1970;28(1):13-23.
http://dx.doi.org/10.1016/0009-8981(70)90155-5