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Abstract:

Potentiometric detection of lipophilic drugs such as clenbuterol, ambroxol and bromhexine in standard-bore cyano and narrow-bore hybrid, reversed-phase HPLC systems was developed to enable specific determination of these mucolytic agents in some marketed oral-formulations. The macrocycle and podant-type, neutral ionophores, respectively: hexakis(2,3,6-tri-O-octyl)-α-cyclodextrin (CDX) and N,N,N′,N′-tetracyclohexyl-oxybis(o-phenyleneoxy)diacetamide (TOPA), were used to construct PVC-based, liquid membrane electrodes. In acidic aqueous-acetonitrile, mobile phases both ionophores improved the sensitivity of these electrodes for mucolytic agents when compared to single-wavelength UV detection - as well as with the ionophore-free based electrode. In the case of bromhexine, indicating highest lipophilicity (logP 6.40), detection limits of 2.6 × 10-10 and 1.4 × -10 M (injected concentration) were achieved with a signal-to-noise (S/N) ratio of 3 with the TOPA-modified, liquid membrane electrode in the variaus RP-HPLC systems. The results of procedures validated for simultaneous potentiometric determination of clenbuterol and ambroxol in tablets marketed in different countries are also presented.

Registro:

Documento: Artículo
Título:Macrocycle versus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes
Autor:Bazylak, G.; Nagels, L.J.; Monge, M.E.
Filiación:Department of Drug Chemistry, Faculty of Pharmacy, Ludwik Rydygier Medical University, Jagiellonska 13, 85-067 Bydgoszcz, Poland
Department of Chemistry, Faculty of Science and Biomedicine, University of Antwerpen RUCA, Groenenborgerlaan 171, 2020 Antwerpen, Belgium
INQUIMAE, Fac. de Cie. Exactas and Naturales, Universidad de Buenos Aires, C1428 EHA Buenos Aires, Argentina
Palabras clave:Column liquid chromatography; Lipophilic drugs; Pharmaceutical formulations; Potentiometric detection; acetonitrile; ambroxol; bromhexine; clenbuterol; hexakis(2,3,6,tri o octyl) alpha cyclodextrin; ionophore; macrocyclic compound; mucolytic agent; n,n,n'n' tetracyclohexyloxybis(2 phenyleneoxy)diacetamide; polyvinylchloride; unclassified drug; acidity; aqueous solution; article; electrode; lipophilicity; liquid membrane; potentiometry; priority journal; reversed phase high performance liquid chromatography; separation technique; signal noise ratio; standardization; ultraviolet radiation; waveform
Año:2003
Volumen:57
Número:11-12
Página de inicio:757
Página de fin:765
DOI: http://dx.doi.org/10.1007/BF02491762
Título revista:Chromatographia
Título revista abreviado:Chromatographia
ISSN:00095893
CODEN:CHRGB
CAS:acetonitrile, 75-05-8; ambroxol, 18683-91-5, 23828-92-4; bromhexine, 3572-43-8, 611-75-6; clenbuterol, 21898-19-1, 37148-27-9; polyvinylchloride, 9002-86-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00095893_v57_n11-12_p757_Bazylak

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Citas:

---------- APA ----------
Bazylak, G., Nagels, L.J. & Monge, M.E. (2003) . Macrocycle versus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes. Chromatographia, 57(11-12), 757-765.
http://dx.doi.org/10.1007/BF02491762
---------- CHICAGO ----------
Bazylak, G., Nagels, L.J., Monge, M.E. "Macrocycle versus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes" . Chromatographia 57, no. 11-12 (2003) : 757-765.
http://dx.doi.org/10.1007/BF02491762
---------- MLA ----------
Bazylak, G., Nagels, L.J., Monge, M.E. "Macrocycle versus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes" . Chromatographia, vol. 57, no. 11-12, 2003, pp. 757-765.
http://dx.doi.org/10.1007/BF02491762
---------- VANCOUVER ----------
Bazylak, G., Nagels, L.J., Monge, M.E. Macrocycle versus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes. Chromatographia. 2003;57(11-12):757-765.
http://dx.doi.org/10.1007/BF02491762