Artículo
Abstract:
Two sulfated xylogalactans (F1 and F7), isolated from the red seaweed Nothogenia fastigiata, achieved a dose-dependent inhibition of the replication of herpes simplex virus type 1 (HSV-1) in Vero cells, with 50% effective doses in the range of 15.0-32.6 μg/ml, and without affecting cell viability at concentrations up to 200 μg/ml. The presence of sulfate groups in the molecule was essential for the antiviral properties of these polysaccharides. F7 afforded significant inhibition in HSV-1 yield if added to the cell cultures simultaneously with virus inoculum, but had no effect when it was added after I h of infection. Analysis of the early events of the viral replicative cycle showed that the anti-HSV effect of F7 was due to a specific inhibition of virus attachment to the host cell, whereas virus internalization was not impaired.
Registro:
| Documento: | Artículo |
| Título: | Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata |
| Autor: | Damonte, E.B.; Matulewicz, M.C.; Cerezo, A.S.; Coto, C.E. |
| Filiación: | Laboratorio de Virologia, Departamento de Quimica Biologica, Fac. Ciencias Exactas y Naturales, 1428 Buenos Aires, Argentina |
| Idioma: | Inglés |
| Palabras clave: | Antiviral properties; Herpesviruses; Red seaweed; Sulfated xylogalactans; antivirus agent; galactan; polysaccharide; sulfate; antiviral activity; article; cell culture; cell viability; controlled study; dose response; herpes simplex virus; herpes simplex virus 1; host cell; internalization; nonhuman; priority journal; seaweed; vero cell; virus adsorption; virus replication; Animal; Antiviral Agents; Cercopithecus aethiops; Galactans; Herpesvirus 1, Human; Seaweed; Support, Non-U.S. Gov't; Vero Cells |
| Año: | 1996 |
| Volumen: | 42 |
| Número: | 1 |
| Página de inicio: | 57 |
| Página de fin: | 64 |
| Título revista: | Chemotherapy |
| Título revista abreviado: | CHEMOTHERAPY |
| ISSN: | 00093157 |
| CODEN: | CHTHB |
| CAS: | galactan, 39300-87-3, 9037-55-2; sulfate, 14808-79-8; Antiviral Agents; Galactans |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte |
Citas:
---------- APA ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S. & Coto, C.E. (1996) . Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata. Chemotherapy, 42(1), 57-64.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]
---------- CHICAGO ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E. "Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata" . Chemotherapy 42, no. 1 (1996) : 57-64.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]
---------- MLA ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E. "Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata" . Chemotherapy, vol. 42, no. 1, 1996, pp. 57-64.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]
---------- VANCOUVER ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E. Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata. CHEMOTHERAPY. 1996;42(1):57-64.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]
