logo biblio digital exactas
logo twitter logo instagram logo whatsapp logo mail

Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor

Abstract:

Two sulfated xylogalactans (F1 and F7), isolated from the red seaweed Nothogenia fastigiata, achieved a dose-dependent inhibition of the replication of herpes simplex virus type 1 (HSV-1) in Vero cells, with 50% effective doses in the range of 15.0-32.6 μg/ml, and without affecting cell viability at concentrations up to 200 μg/ml. The presence of sulfate groups in the molecule was essential for the antiviral properties of these polysaccharides. F7 afforded significant inhibition in HSV-1 yield if added to the cell cultures simultaneously with virus inoculum, but had no effect when it was added after I h of infection. Analysis of the early events of the viral replicative cycle showed that the anti-HSV effect of F7 was due to a specific inhibition of virus attachment to the host cell, whereas virus internalization was not impaired.

Registro:

Documento: Artículo
Título:Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata
Autor:Damonte, E.B.; Matulewicz, M.C.; Cerezo, A.S.; Coto, C.E.
Filiación:Laboratorio de Virologia, Departamento de Quimica Biologica, Fac. Ciencias Exactas y Naturales, 1428 Buenos Aires, Argentina
Idioma: Inglés
Palabras clave:Antiviral properties; Herpesviruses; Red seaweed; Sulfated xylogalactans; antivirus agent; galactan; polysaccharide; sulfate; antiviral activity; article; cell culture; cell viability; controlled study; dose response; herpes simplex virus; herpes simplex virus 1; host cell; internalization; nonhuman; priority journal; seaweed; vero cell; virus adsorption; virus replication; Animal; Antiviral Agents; Cercopithecus aethiops; Galactans; Herpesvirus 1, Human; Seaweed; Support, Non-U.S. Gov't; Vero Cells
Año:1996
Volumen:42
Número:1
Página de inicio:57
Página de fin:64
Título revista:Chemotherapy
Título revista abreviado:CHEMOTHERAPY
ISSN:00093157
CODEN:CHTHB
CAS:galactan, 39300-87-3, 9037-55-2; sulfate, 14808-79-8; Antiviral Agents; Galactans
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte

Citas:

---------- APA ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S. & Coto, C.E. (1996) . Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata. Chemotherapy, 42(1), 57-64.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]
---------- CHICAGO ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E. "Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata" . Chemotherapy 42, no. 1 (1996) : 57-64.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]
---------- MLA ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E. "Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata" . Chemotherapy, vol. 42, no. 1, 1996, pp. 57-64.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]
---------- VANCOUVER ----------
Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E. Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata. CHEMOTHERAPY. 1996;42(1):57-64.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v42_n1_p57_Damonte [ ]