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Abstract:

A frequent coexistence of diabetes and porphyria disease has been reported. Under normal conditions, porphyrin biosynthesis is well regulated to only form the amount of heme required for the synthesis of the various hemoproteins. The activity of some heme enzymes and rhodanese in streptozotocin (STZ) induced diabetic mice and in allylisopropylacetamide (AIA) induced experimental acute porphyria mice has been examined. The role of α-tocopherol (α-T), reported to prevent protein glycation in vitro, has also been investigated. AIA induced hepatic δ-aminolevulinic acid synthetase (ALA-S) activity in control animals but was ineffective in the diabetic group. α-Tocopherol did not modify ALA-S activity in either group. δ-Aminolevulinic acid dehydratase (ALA-D) and deaminase activities were significantly diminished both in liver and blood of diabetic animals. α-Tocopherol prevented inhibition of ALA-D, deaminase and blood rhodanese activities in diabetic animals but α-tocopherol by itself did not affect the basal levels of the enzymes studied. The potential use of a-tocopherol to prevent late complications of diabetes, including the onset of a porphyria like syndrome is considered. © 1995.

Registro:

Documento: Artículo
Título:STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and α-tocopherol
Autor:Polo, C.F.; Vázquez, E.S.; Gerez, E.N.; Caballero, F.A.; del C. Batlle, A.M.
Filiación:Centro de Investigacions sobre Porfirinas y Porfirias (CIPYP), (CONICET - UBA), Ciudad Universitaria, Pabellon II, 2do Piso, 1428 Buenos Aires, Argentina
Palabras clave:Allylisopropylacetamide; Streptozotocin induced diabetes; α-Tocopherol; δ-Aminolevulinic acid; 5 aminolevulinate synthase; allylisopropylacetamide; alpha tocopherol; deaminase; porphobilinogen synthase; streptozocin; thiosulfate sulfurtransferase; acute intermittent porphyria; animal experiment; animal model; animal tissue; article; blood level; controlled study; disease association; heme synthesis; intraperitoneal drug administration; liver level; male; mouse; nonhuman; protein glycosylation; streptozocin diabetes; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animal; Blood Glucose; Diabetes Mellitus, Experimental; Heme; Male; Mice; Nucleoside Deaminases; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Streptozocin; Support, Non-U.S. Gov't; Thiosulfate Sulfurtransferase; Vitamin E
Año:1995
Volumen:95
Número:3
Página de inicio:327
Página de fin:334
DOI: http://dx.doi.org/10.1016/0009-2797(94)03573-Q
Título revista:Chemico-Biological Interactions
Título revista abreviado:Chem.-Biol. Interact.
ISSN:00092797
CODEN:CBINA
CAS:5 aminolevulinate synthase, 9037-14-3; allylisopropylacetamide, 299-78-5; alpha tocopherol, 1406-18-4, 1406-70-8, 52225-20-4, 58-95-7, 59-02-9; deaminase, 9067-84-9; porphobilinogen synthase, 9036-37-7; streptozocin, 18883-66-4; thiosulfate sulfurtransferase, 9026-04-4; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Allylisopropylacetamide, 299-78-5; Blood Glucose; Heme, 14875-96-8; Nucleoside Deaminases, EC 3.5.4; Porphobilinogen Synthase, EC 4.2.1.24; Streptozocin, 18883-66-4; Thiosulfate Sulfurtransferase, EC 2.8.1.1; Vitamin E, 1406-18-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00092797_v95_n3_p327_Polo

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Citas:

---------- APA ----------
Polo, C.F., Vázquez, E.S., Gerez, E.N., Caballero, F.A. & del C. Batlle, A.M. (1995) . STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and α-tocopherol. Chemico-Biological Interactions, 95(3), 327-334.
http://dx.doi.org/10.1016/0009-2797(94)03573-Q
---------- CHICAGO ----------
Polo, C.F., Vázquez, E.S., Gerez, E.N., Caballero, F.A., del C. Batlle, A.M. "STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and α-tocopherol" . Chemico-Biological Interactions 95, no. 3 (1995) : 327-334.
http://dx.doi.org/10.1016/0009-2797(94)03573-Q
---------- MLA ----------
Polo, C.F., Vázquez, E.S., Gerez, E.N., Caballero, F.A., del C. Batlle, A.M. "STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and α-tocopherol" . Chemico-Biological Interactions, vol. 95, no. 3, 1995, pp. 327-334.
http://dx.doi.org/10.1016/0009-2797(94)03573-Q
---------- VANCOUVER ----------
Polo, C.F., Vázquez, E.S., Gerez, E.N., Caballero, F.A., del C. Batlle, A.M. STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and α-tocopherol. Chem.-Biol. Interact. 1995;95(3):327-334.
http://dx.doi.org/10.1016/0009-2797(94)03573-Q