Artículo
Franco, L.H.; Palermo, J.A. "Synthesis of 2-(pyrimidin-4-yl)indoles" (2003) Chemical and Pharmaceutical Bulletin. 51(8):975-977
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
The synthesis of 2-substituted isomers of the meridianins, a familiy of bioactive indole alkaloids isolated from the tunicate Aplidium meridianum, was undertaken. The synthetic route comprises six steps, with a microwave promoted Fischer cyclization as the key reaction. © 2003 Pharmaceutical Society of Japan.
Registro:
| Documento: | Artículo |
| Título: | Synthesis of 2-(pyrimidin-4-yl)indoles |
| Autor: | Franco, L.H.; Palermo, J.A. |
| Filiación: | Departamento de Química Orgánica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentina Ciudad Universitaria, Pabellón 2, (1428) Buenos Aires, Argentina |
| Palabras clave: | Fischer indole synthesis; Meridianin; Microwave; indole alkaloid; indole derivative; meridianin; unclassified drug; indole alkaloid; indole derivative; pyrimidine; pyrimidine derivative; article; cyclization; drug isolation; drug synthesis; Fischer Tropsch synthesis; isomer; microwave radiation; animal; synthesis; Urochordata; Animals; Indole Alkaloids; Indoles; Pyrimidines; Urochordata |
| Año: | 2003 |
| Volumen: | 51 |
| Número: | 8 |
| Página de inicio: | 975 |
| Página de fin: | 977 |
| DOI: | http://dx.doi.org/10.1248/cpb.51.975 |
| Título revista: | Chemical and Pharmaceutical Bulletin |
| Título revista abreviado: | Chem. Pharm. Bull. |
| ISSN: | 00092363 |
| CODEN: | CPBTA |
| CAS: | pyrimidine, 289-95-2; Indole Alkaloids; Indoles; pyrimidine, 289-95-2; Pyrimidines |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00092363_v51_n8_p975_Franco |
Referencias:
- Dedicated to the memory of Dr. Alicia M. Seldes, founder and leader of the research group on Marine Natural Products at the Department of Organic Chemistry, FCEN-UBA; Hernández Franco, L., Bal De Kier Joffé, E., Puricelli, L., Tatian, M., Seldes, A.M., Palermo, J.A., (1998) J. Nat. Prod., 61, pp. 1130-1132
- Butler, M.S., Capon, R.J., Lu, C.C., (1992) Aust. J. Chem., 45, pp. 1871-1877
- Perry, N.B., Ettouati, L., Litaudon, M., Blunt, J.W., Munro, M.H.G., Parkin, S., Hope, H., (1994) Tetrahedron, 50, pp. 3987-3992
- Fresneda, P.M., Molina, P., Bleda, J.A., (2001) Tetrahedron, 57, pp. 2355-2363
- Jiang, B., Yang, C.-G., Xiong, W.-N., Wang, J., (2001) Bioorg. Med. Chem., 9, pp. 1149-1154
- Gan, T., Liu, R., Yu, P., Zhao, S., Cook, J.M., (1997) J. Org. Chem., 62, pp. 9298-9304
- Yamanoka, N., Aso, K., (1962) J. Org. Chem., 27, pp. 1462-1463
- Soldberg, J., Undheim, K., (1989) Acta Chem. Scand., 43, pp. 62-68
- Stille, J.K., (1986) Angew. Chem. Int. Ed. Engl., 25, pp. 508-524
- Majeed, A.J., Antonsen, O., Benneche, T., Undheim, K., (1989) Tetrahedron, 45, pp. 993-1006
- Lipinska, T., Guibé-Jampel, E., Petit, A., Loupy, A., (1999) Synth. Commun., 29, pp. 1349-1354
- Villemin, D., Labiad, B., Ouhilal, Y., (1989) Chem. & Ind., pp. 607-609. , London
- Abramovitch, R.A., Bulman, A., (1992) Synlett, 1992, pp. 795-796
Citas:
---------- APA ----------
Franco, L.H. & Palermo, J.A. (2003) . Synthesis of 2-(pyrimidin-4-yl)indoles. Chemical and Pharmaceutical Bulletin, 51(8), 975-977.http://dx.doi.org/10.1248/cpb.51.975
---------- CHICAGO ----------
Franco, L.H., Palermo, J.A. "Synthesis of 2-(pyrimidin-4-yl)indoles" . Chemical and Pharmaceutical Bulletin 51, no. 8 (2003) : 975-977.http://dx.doi.org/10.1248/cpb.51.975
---------- MLA ----------
Franco, L.H., Palermo, J.A. "Synthesis of 2-(pyrimidin-4-yl)indoles" . Chemical and Pharmaceutical Bulletin, vol. 51, no. 8, 2003, pp. 975-977.http://dx.doi.org/10.1248/cpb.51.975
---------- VANCOUVER ----------
Franco, L.H., Palermo, J.A. Synthesis of 2-(pyrimidin-4-yl)indoles. Chem. Pharm. Bull. 2003;51(8):975-977.http://dx.doi.org/10.1248/cpb.51.975
