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Abstract:

A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range. © 2009 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
Autor:Prado, H.J.; Matulewicz, M.C.; Bonelli, P.R.; Cukierman, A.L.
Filiación:Departamento de Química Orgánica (CIHIDECAR-CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina
PINMATE-Departamento de Industrias, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina
Cátedra de Farmacotecnia II, Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Junín 956, C1113AAD Buenos Aires, Argentina
Palabras clave:Cationized starch; Controlled release; Ibuprofen; Interpolyelectrolyte complex; Kappa-carrageenan; Matrix system; Cationized starch; Controlled release; Ibuprofen; Interpolyelectrolyte complex; Kappa-carrageenan; Matrix system; Dissolution; Starch; Turbidity; Controlled drug delivery; buffer; ibuprofen; polyelectrolyte; starch; article; controlled drug release; diffusion; dissolution; drug delivery system; drug synthesis; infrared spectroscopy; measurement; performance; pH; priority journal; tablet; tablet matrix; turbidity; Amylose; Carbohydrate Sequence; Carrageenan; Diffusion; Drug Carriers; Electrolytes; Ibuprofen; Pharmaceutical Preparations; Quaternary Ammonium Compounds; Spectroscopy, Fourier Transform Infrared; Starch; Tablets
Año:2009
Volumen:344
Número:11
Página de inicio:1325
Página de fin:1331
DOI: http://dx.doi.org/10.1016/j.carres.2009.04.026
Título revista:Carbohydrate Research
Título revista abreviado:Carbohydr. Res.
ISSN:00086215
CODEN:CRBRA
CAS:ibuprofen, 15687-27-1, 79261-49-7; starch, 9005-25-8, 9005-84-9; Amylose, 9005-82-7; Carrageenan, 9000-07-1; Drug Carriers; Electrolytes; Ibuprofen, 15687-27-1; Pharmaceutical Preparations; Quaternary Ammonium Compounds; Starch, 9005-25-8; Tablets
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v344_n11_p1325_Prado

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Citas:

---------- APA ----------
Prado, H.J., Matulewicz, M.C., Bonelli, P.R. & Cukierman, A.L. (2009) . Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release. Carbohydrate Research, 344(11), 1325-1331.
http://dx.doi.org/10.1016/j.carres.2009.04.026
---------- CHICAGO ----------
Prado, H.J., Matulewicz, M.C., Bonelli, P.R., Cukierman, A.L. "Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release" . Carbohydrate Research 344, no. 11 (2009) : 1325-1331.
http://dx.doi.org/10.1016/j.carres.2009.04.026
---------- MLA ----------
Prado, H.J., Matulewicz, M.C., Bonelli, P.R., Cukierman, A.L. "Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release" . Carbohydrate Research, vol. 344, no. 11, 2009, pp. 1325-1331.
http://dx.doi.org/10.1016/j.carres.2009.04.026
---------- VANCOUVER ----------
Prado, H.J., Matulewicz, M.C., Bonelli, P.R., Cukierman, A.L. Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release. Carbohydr. Res. 2009;344(11):1325-1331.
http://dx.doi.org/10.1016/j.carres.2009.04.026