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Abstract:

The brown seaweed Sargassum stenophyllum biosynthesizes two different sets of fucoidans. One of them is characterized by higher percentages of glucuronic acid and fewer sulfate groups, which are situated on different sugar units. α-L-Fucose was the major component but other sugars like β-D-galactose, β-D-mannose, α-D-glucuronic acid, α-D-glucose and β-D-xylose were also in substantial amounts. Fucoidans from the other set contain small amounts of α-D-glucuronic acid and high percentages of sulfate groups, which are concentrated on the fucose residues, with only fucose and galactose as major components. Structural studies of one fucoidan from each set suggest that these products have a general basic structure that has a formal resemblance to that of the fucosylated chondroitin sulfates from the body wall of sea cucumbers, namely, a linear core (formed mainly by (1→6)-β-D-galactose and/or (1→2)-β-D-mannose units) with branched chains of 'fucans' (formed by (1→3) and/or (1→4)-α-L-fucose, (1→4)-α-D-glucuronic acid, terminal β-D-xylose and, sometimes, (1→4)-α-D-glucose). In fucoidans from the second set, the 'core' is reduced to short galactan chains. © 2001 Elsevier Science Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
Autor:Duarte, M.E.R.; Cardoso, M.A.; Noseda, M.D.; Cerezo, A.S.
Filiación:Departamento De Bioquímica, Universidade Federal Do Paraná, PO Box 19046, CEP 81531-990 Curitiba, Parana, Brazil
Departamento De Química Orgánica, CIHIDECAR-CONICET, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Brown seaweed; Chemical structure; Fucans; Fucoidans; Sargassum stenophyllum; Sulfated heteropolysaccharides; Organic acids; Polysaccharides; Sugars; Fucoidans; Carbohydrates; alpha glucose; alpha glucuronic acid; alpha levo fucose; beta galactose; beta xylose; chondroitin sulfate; fucoidin; fucose; galactose; glucose; glucuronic acid; mannose; sulfur derivative; unclassified drug; xylose; article; biosynthesis; drug structure; echinoderm; fucosylation; nonhuman; priority journal; seaweed; structure analysis; Anticoagulants; Blood Coagulation; Humans; Monosaccharides; Nuclear Magnetic Resonance, Biomolecular; Optical Rotation; Partial Thromboplastin Time; Polysaccharides; Seaweed; Thrombin Time; algae; Cucumis sativus; Holothuroidea; Sargassum stenophyllum
Año:2001
Volumen:333
Número:4
Página de inicio:281
Página de fin:293
DOI: http://dx.doi.org/10.1016/S0008-6215(01)00149-5
Título revista:Carbohydrate Research
Título revista abreviado:Carbohydr. Res.
ISSN:00086215
CODEN:CRBRA
CAS:Anticoagulants; fucoidan, 9072-19-9; Monosaccharides; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v333_n4_p281_Duarte

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Citas:

---------- APA ----------
Duarte, M.E.R., Cardoso, M.A., Noseda, M.D. & Cerezo, A.S. (2001) . Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum. Carbohydrate Research, 333(4), 281-293.
http://dx.doi.org/10.1016/S0008-6215(01)00149-5
---------- CHICAGO ----------
Duarte, M.E.R., Cardoso, M.A., Noseda, M.D., Cerezo, A.S. "Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum" . Carbohydrate Research 333, no. 4 (2001) : 281-293.
http://dx.doi.org/10.1016/S0008-6215(01)00149-5
---------- MLA ----------
Duarte, M.E.R., Cardoso, M.A., Noseda, M.D., Cerezo, A.S. "Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum" . Carbohydrate Research, vol. 333, no. 4, 2001, pp. 281-293.
http://dx.doi.org/10.1016/S0008-6215(01)00149-5
---------- VANCOUVER ----------
Duarte, M.E.R., Cardoso, M.A., Noseda, M.D., Cerezo, A.S. Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum. Carbohydr. Res. 2001;333(4):281-293.
http://dx.doi.org/10.1016/S0008-6215(01)00149-5