Artículo
Horton, D.; Varela, O. "Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose" (2000) Carbohydrate Research. 328(3):425-429
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Abstract:
3-Deoxy-D-erythro-hexos-2-ulose bis(thiosemicarbazone) (1) acts as a tetradentate ligand of the N2S2 type which forms stable coordination complexes with metal(II) cations. The Cu(II), Pt(II), and Pd(II) chelates (2, 4, and 6, respectively) of 1 were synthesized and characterized by elemental analysis and NMR spectroscopy. The NMR spectra of the Pt complex (4) showed the coupling of H-1 and C-1, C-2 of the bis(thiosemicarbazone) with 195Pt (33.7% naturally occurring), which supports the structure proposed for the chelate. The complexes 2, 4, and 6 were acetylated to give the corresponding tri-O-acetyl derivatives 3, 5, and 7. Elimination of Cu(II) from 3 with hydrogen sulfide afforded 8, the tri-O-acetyl derivative of 1. Preliminary studies have shown antiviral activity of chelates 2, 4, and 6 against poliovirus type 1. (C) 2000 Elsevier Science Ltd.
Registro:
| Documento: | Artículo |
| Título: | Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose |
| Autor: | Horton, D.; Varela, O. |
| Filiación: | Department of Chemistry, Amer. Univ., 4400 Massachusetts A., Washington, DC 20016-8014, United States CIHIDECAR (CONICET)-Depto. Quim. O., Fac. Cie. Exact. Y Nat., Univ. B., Buenos Aires, Argentina |
| Palabras clave: | Bis(thiosemicarbazone); Chelates; Copper; Palladium; Platinum; 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) palladium chelate; 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) platinum chelate; acetic acid derivative; chelate; copper; glucose; hydrogen sulfide; metal ion; palladium complex; platinum; thiosemicarbazone derivative; unclassified drug; antiviral activity; article; complex formation; nuclear magnetic resonance spectroscopy; Poliomyelitis virus 1; priority journal; Animal; Antiviral Agents; Cercopithecus aethiops; Copper; Glucose; Human; Magnetic Resonance Spectroscopy; Palladium; Platinum Compounds; Poliovirus; Thiosemicarbazones; Vero Cells |
| Año: | 2000 |
| Volumen: | 328 |
| Número: | 3 |
| Página de inicio: | 425 |
| Página de fin: | 429 |
| DOI: | http://dx.doi.org/10.1016/S0008-6215(00)00118-X |
| Título revista: | Carbohydrate Research |
| Título revista abreviado: | Carbohydr. Res. |
| ISSN: | 00086215 |
| CODEN: | CRBRA |
| CAS: | copper, 15158-11-9, 7440-50-8; glucose, 50-99-7, 84778-64-3; hydrogen sulfide, 15035-72-0, 7783-06-4; platinum, 7440-06-4; Antiviral Agents; Copper, 7440-50-8; Glucose, 50-99-7; Palladium, 7440-05-3; Platinum Compounds; Thiosemicarbazones |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v328_n3_p425_Horton |
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Citas:
---------- APA ----------
Horton, D. & Varela, O. (2000) . Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose. Carbohydrate Research, 328(3), 425-429.http://dx.doi.org/10.1016/S0008-6215(00)00118-X
---------- CHICAGO ----------
Horton, D., Varela, O. "Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose" . Carbohydrate Research 328, no. 3 (2000) : 425-429.http://dx.doi.org/10.1016/S0008-6215(00)00118-X
---------- MLA ----------
Horton, D., Varela, O. "Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose" . Carbohydrate Research, vol. 328, no. 3, 2000, pp. 425-429.http://dx.doi.org/10.1016/S0008-6215(00)00118-X
---------- VANCOUVER ----------
Horton, D., Varela, O. Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose. Carbohydr. Res. 2000;328(3):425-429.http://dx.doi.org/10.1016/S0008-6215(00)00118-X
