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Abstract:

BACKGROUND. Bone marrow (BM) is an important tissue in the generation of immunocompetent and peripheral blood cells. The precursors of hematopoietic cells in BM undergo continuous proliferation and differentiation and are highly vulnerable to acute and chronic oxidative stress. Little is known about the oxidant and antioxidant status in the BM of untreated patients with nonhematologic tumors. In this study, oxidative stress was evaluated in peripheral blood plasma (PBP) and BM plasma (BMP) from lung carcinoma (LC) and breast carcinoma (BC) patients. METHODS. The sample included 13 consecutive untreated LC patients, 15 BC patients, and 11 healthy controls. Luminol-dependent chemiluminescence was used to evaluate oxygen radical generation by peripheral blood neutrophils. Lipid oxidation, assessed by 2-thiobarbituric acid-reactive substances (TBARS), and α-tocopherol, β-carotene, and total ubiquinol-10 levels were determined in PBP and BMP. RESULTS. In LC and BC patients, neutrophil chemiluminescence was higher (128% and 264%, respectively) than in controls (P < 0.05). In cancer patients, TBARS levels were higher in both PBP (51% and 243% for LC and BC patients, respectively) and BMP (66% and 305% for LC and BC patients, respectively) than in plasma from controls (P < 0.01). α-Tocopherol and total ubiquinol-10 levels were significantly lower in BMP from BC patients compared with controls. In BC patients, α-tocopherol content in PBP was significantly lower than in controls. CONCLUSIONS. Untreated cancer patients presented an imbalance between oxidant generation and lipid-soluble antioxidant levels in favor of the former. © 2002 American Cancer Society.

Registro:

Documento: Artículo
Título:Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients
Autor:De Cavanagh, E.M.V.; Honegger, A.E.; Hofer, E.; Bordenave, R.H.; Bullorsky, E.O.; Chasseing, N.A.; Fraga, C.
Filiación:Fsicoquimica-PRALIB, Facultad de Farmacia Y Bioquímica, Universidad de Buenos Aires, Argentina
Instituto de Biología Y Medicina Experimental, Buenos Aires, Argentina
Department of Hematology and Bone Marrow Transplantation, British Hospital, Buenos Aires, Argentina
Department of Oncology, I. Iriarte Hospital, Buenos Aires, Argentina
Instituto de Biología Y Medicina Experimental, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Antioxidants; Bone marrow; Cancer; Free radicals; Lipid oxidation; Peripheral blood; alpha tocopherol; antioxidant; beta carotene; free radical; thiobarbituric acid reactive substance; adult; advanced cancer; article; blood; bone marrow; breast carcinoma; chemoluminescence; clinical article; human; lipid oxidation; lung carcinoma; oxidation; oxidative stress; plasma; priority journal; Adult; Antioxidants; Bone Marrow; Chemiluminescent Measurements; Humans; Lipid Peroxidation; Middle Aged; Neoplasms; Neutrophils; Oxidation-Reduction
Año:2002
Volumen:94
Número:12
Página de inicio:3247
Página de fin:3251
DOI: http://dx.doi.org/10.1002/cncr.10611
Título revista:Cancer
Título revista abreviado:Cancer
ISSN:0008543X
CODEN:CANCA
CAS:Antioxidants
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0008543X_v94_n12_p3247_DeCavanagh

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Citas:

---------- APA ----------
De Cavanagh, E.M.V., Honegger, A.E., Hofer, E., Bordenave, R.H., Bullorsky, E.O., Chasseing, N.A. & Fraga, C. (2002) . Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients. Cancer, 94(12), 3247-3251.
http://dx.doi.org/10.1002/cncr.10611
---------- CHICAGO ----------
De Cavanagh, E.M.V., Honegger, A.E., Hofer, E., Bordenave, R.H., Bullorsky, E.O., Chasseing, N.A., et al. "Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients" . Cancer 94, no. 12 (2002) : 3247-3251.
http://dx.doi.org/10.1002/cncr.10611
---------- MLA ----------
De Cavanagh, E.M.V., Honegger, A.E., Hofer, E., Bordenave, R.H., Bullorsky, E.O., Chasseing, N.A., et al. "Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients" . Cancer, vol. 94, no. 12, 2002, pp. 3247-3251.
http://dx.doi.org/10.1002/cncr.10611
---------- VANCOUVER ----------
De Cavanagh, E.M.V., Honegger, A.E., Hofer, E., Bordenave, R.H., Bullorsky, E.O., Chasseing, N.A., et al. Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients. Cancer. 2002;94(12):3247-3251.
http://dx.doi.org/10.1002/cncr.10611