Navegar

Colección

Datos Estadísticas

Artículo

Ballare, C.; Bravo, A.I.; Sorin, I.; Guman, N.; Schiaffi, J.A.; Yomha, R.; Bagnati, A.; Lema, B.; Mordoh, J. "The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer" (1991) Cancer. 67(5):1352-1358
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Two main models to account for the heterogeneous expression of estrogen receptors (ER) and progesterone receptors (PR) in human breast cancer have been proposed: the clonal model and the stem cell model. The authors previously provided evidence supporting the stem cell model since it was found that most of the proliferating cells in ER‐positive (ER+) human breast cancer lack ER and that the ER‐negative (ER−) and ER+ subpopulations are interrelated. The authors have analyzed in eighteen ER+/PR+ primary breast tumors the simultaneous expression of ER or PR (by immunohistochemistry) and DNA synthesis (by autoradiography) after 30 minutes of 3H‐thymidine incorporation. The authors demonstrated that: (1) the average numbers of ER+ and PR+ cells were similar (36.8 ± 10.7% and 39.3 ± 17.6%, respectively); (2) The thymidine‐labeling indexes of the ER+, ER−, PR+, and PR− subpopulations were 0.53 ± 0.69%, 0.74 ± 0.49%, 0.21 ± 0.21 and 0.94 ± 0.54%, respectively; and (3) 75.2% of the DNA‐synthesizing cells were ER−, and 88.8% of them were PR−. The authors conclude that the cellular subpopulations expressing ER and PR were not identical, and the expression of PR was associated with a lower rate of cellular proliferation than was ER expression. Copyright © 1991 American Cancer Society

Registro:

Documento: Artículo
Título:The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer
Autor:Ballare, C.; Bravo, A.I.; Sorin, I.; Guman, N.; Schiaffi, J.A.; Yomha, R.; Bagnati, A.; Lema, B.; Mordoh, J.
Filiación:Hospital Mariano R. Castex, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina
Hospital Rivadavia, Facultad de Ciencias Exactas Y Naturales, Buenos Aires, Argentina
Institute de Investigaciones Bioquimicas "Fundacion Campomar" and Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina
Palabras clave:progesterone receptor; antigen expression; article; autoradiography; breast cancer; clinical article; dna synthesis; female; growth inhibition; human; human tissue; immunohistochemistry; priority journal; Breast Neoplasms; Carcinoma; DNA Replication; DNA, Neoplasm; Female; Human; Immunohistochemistry; Receptors, Estrogen; Receptors, Progesterone; Reproducibility of Results; Support, Non-U.S. Gov't
Año:1991
Volumen:67
Número:5
Página de inicio:1352
Página de fin:1358
DOI: http://dx.doi.org/10.1002/1097-0142(19910301)67:5<1352::AID-CNCR2820670514>3.0.CO;2-S
Título revista:Cancer
Título revista abreviado:Cancer
ISSN:0008543X
CAS:DNA, Neoplasm; Receptors, Estrogen; Receptors, Progesterone
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0008543X_v67_n5_p1352_Ballare

Referencias:

  • McGuire, WL, Clark, GM, Dressler, LB, Owens, MA, Role of steroid hormone receptors as prognostic factors in primary breast cancer (1986) NCI Monogr, 1, pp. 19-23
  • Thorpe, SM, Rose, C, Rasmussen, BB, Mouridsen, HT, Bayer, T, Kieding, N, Prognostic value of steroid hormone receptors: Multivariate analysis of systemically untreated patients with node negative primary breast cancer (1987) Cancer Res, 47, pp. 6126-6133
  • Raemakers, JM, Beex, LV, Pieters, GF, Smals, AG, Benraad, TJ, Kloppenborg, PW, Progesterone receptor activity and the response to the first endocrine therapy in advanced breast cancer (1987) European Journal of Cancer and Clinical Oncology, 23, pp. 443-448
  • Poulsen, HS, Jensen, J, Hermansen, C, Human breast cancer: Heterogeneity of estrogen binding sites (1981) Cancer, 48, pp. 1791-1793
  • Taylor, RE, Powles, TJ, Humphreys, J, Effects of endocrine therapy on steroid‐receptor content of breast cancer (1982) Br J Cancer, 45, pp. 80-85
  • Buick, RN, The cellular basis of cancer chemotherapy (1984) Antineoplastic Agents, pp. 1-39. , Remers WA, New York, John Wiley and Sons
  • Selby, P, Bizzari, J‐P, Buick, RN, Therapeutic implications of a stem cell model in human breast cancer: A hypothesis (1983) Cancer Treat Rep, 67, pp. 659-663
  • Ballare, C, Bravo, AI, Laucella, S, DNA synthesis in estrogen receptor‐positive human breast cancer takes place preferentially in estrogen receptor‐negative cells (1989) Cancer, 64, pp. 842-848
  • Bloom, HJG, Richardson, WW, Histological grading and prognosis in breast cancer (1957) Br J Cancer, 11, pp. 359-377
  • Bravo, AI, Sorin, I, Guman, N, Mordoh, J, Carcinoembryonic antigen and differentiation in human breast cancer (1985) J Exp Clin Cancer Res, 4, pp. 3-9
  • Kruskal, W, Wallis, W, Use of ranks in one‐criterion variance analysis (1952) Journal of the American Statistical Association, 47, pp. 583-621
  • Vollmer, G, Gerdes, J, Knuppen, R, Relationship of cytosolic estrogen and progesterone receptor content and the growth fraction in human mammary carcinomas (1989) Cancer Res, 49, pp. 4011-4014
  • Sherman, MR, Corvol, PL, O'Malley, BW, Progesterone‐binding components of chick oviduct (1970) J Biol Chem, 245, pp. 6085-6096
  • Faber, LE, Sandmann, ML, Stavely, HE, Progesterone‐binding proteins of the rat and rabbit uterus (1972) J Biol Chem, 247, pp. 5648-5649
  • Horwitz, KB, McGuire, WL, Estrogen control of progesterone receptor in human breast cancer (1978) J Biol Chem, 253, pp. 2223-2228
  • Brown, AMC, Jeltsch, J‐M, Roberts, M, Chambon, P, Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF‐7 (1984) Proc Natl Acad Sci U S A, 81, pp. 6344-6348
  • O'Malley, B, In vitro hormonal induction of a specific protein (avidin) in chick oviduct (1967) Biochemistry, 6, pp. 2546-2551
  • Chalbos, D, Rochefort, H, Dual effects of the progestin R 5020 on proteins released by the T 47 D human breast cancer cells (1984) J Biol Chem, 259, pp. 1231-1238
  • Kuttenn, F, Fournier, S, Durand, JC, Mauvais‐Jarvis, P, Baudot, N, Doukani, A, Estradiol and progesterone receptors in human breast fibroadenomas (1981) J Clin Endocrinol Metab, 52, pp. 1225-1229
  • Hsueh, AJW, Peck, EJ, Clark, JH, Control of uterine estrogen receptor levels by progesterone (1976) Endocrinology, 98, pp. 438-444
  • Sutherland, RL, Hall, RE, Pang, GYN, Musgrove, EA, Clarke, CL, Effect of medroxyprogesterone acetate on proliferation and cell cycle kinetics of human mammary carcinoma cells (1988) Cancer Res, 48, pp. 5084-5091
  • Brunner, N, Bronzert, D, Vindelov, LL, Rygaard, K, Spang‐Thomsen, M, Lippman, ME, Effect on growth and cell cycle kinetics of estradiol and tamoxifen on MCF‐7 human breast cancer cells grown in vitro and in nude mice (1989) Cancer Res, 49, pp. 1515-1520
  • Misrahi, M, Atger, M, d'Auriol, L, Complete aminoacid sequence of the human progesterone receptor deduced from cloned cDNA (1987) Biochem Biophys Res Commun, 143, pp. 740-748
  • (1982) Proceedings of the International Symposium on Medroxyprogesterone Acetate, pp. 1-612. , Cavalli F, McGuire WJ, Pannuti F, Pellegrini A, Robustelli Della, Cuna G, Amsterdam, Excerpta Medica

Citas:

---------- APA ----------
Ballare, C., Bravo, A.I., Sorin, I., Guman, N., Schiaffi, J.A., Yomha, R., Bagnati, A.,..., Mordoh, J. (1991) . The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer. Cancer, 67(5), 1352-1358.
http://dx.doi.org/10.1002/1097-0142(19910301)67:5<1352::AID-CNCR2820670514>3.0.CO;2-S
---------- CHICAGO ----------
Ballare, C., Bravo, A.I., Sorin, I., Guman, N., Schiaffi, J.A., Yomha, R., et al. "The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer" . Cancer 67, no. 5 (1991) : 1352-1358.
http://dx.doi.org/10.1002/1097-0142(19910301)67:5<1352::AID-CNCR2820670514>3.0.CO;2-S
---------- MLA ----------
Ballare, C., Bravo, A.I., Sorin, I., Guman, N., Schiaffi, J.A., Yomha, R., et al. "The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer" . Cancer, vol. 67, no. 5, 1991, pp. 1352-1358.
http://dx.doi.org/10.1002/1097-0142(19910301)67:5<1352::AID-CNCR2820670514>3.0.CO;2-S
---------- VANCOUVER ----------
Ballare, C., Bravo, A.I., Sorin, I., Guman, N., Schiaffi, J.A., Yomha, R., et al. The expression of progesterone receptors coincides with an arrest of DNA synthesis in human breast cancer. Cancer. 1991;67(5):1352-1358.
http://dx.doi.org/10.1002/1097-0142(19910301)67:5<1352::AID-CNCR2820670514>3.0.CO;2-S