Artículo
Abstract:
Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the stimulatory action of U-46619 in diabetic preparations. Moreover, inhibitors of thromboxane synthesis completely blocked the stimulatory effects of U-46619. The stimulant action of the thromboxane A2 mimetic was attenuated when diabetic auricles were incubated with lipoxygenase(s) blocking agents. Results suggest that in diabetic atria the abnormal inotropic effect induced by U-46619 may be associated with thromboxane formation and with lipoxygenase(s) metabolites.
Registro:
| Documento: | Artículo |
| Título: | Diabetes alters the reactivity of myocardium to a thromboxane analogue |
| Autor: | Canga, L.; Gorelik, G.; Sterin-Borda, L. |
| Filiación: | Centro de Estudios Farmacologlicos y de Principios Naturales (CEFAPRIN), (1414) Buenos Aires, Argentina |
| Palabras clave: | 1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine; 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; acetylsalicylic acid; dithizone; imidazole; indometacin; lipoxygenase; nictindole; nordihydroguaiaretic acid; prostaglandin synthase; thromboxane derivative; tranylcypromine; animal; animal cell; diabetes mellitus; dose response; drug administration; drug antagonism; drug efficacy; drug interaction; drug mechanism; endocrine system; etiology; heart; heart muscle; heart muscle contractility; in vitro study; pharmacokinetics; priority journal; rat |
| Año: | 1987 |
| Volumen: | 65 |
| Número: | 4 |
| Página de inicio: | 499 |
| Página de fin: | 503 |
| DOI: | http://dx.doi.org/10.1139/y87-085 |
| Título revista: | Canadian Journal of Physiology and Pharmacology |
| Título revista abreviado: | CAN. J. PHYSIOL. PHARMACOL. |
| ISSN: | 00084212 |
| CODEN: | CJPPA |
| CAS: | 1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine, 19395-87-0; 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid, 56985-40-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; dithizone, 60-10-6; imidazole, 1467-16-9, 288-32-4; indometacin, 53-86-1, 74252-25-8, 7681-54-1; lipoxygenase, 9027-17-2, 9029-60-1; nictindole, 36504-64-0; nordihydroguaiaretic acid, 500-38-9; prostaglandin synthase, 39391-18-9, 59763-19-8, 9055-65-6; tranylcypromine, 13492-01-8, 155-09-9, 54-97-7 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v65_n4_p499_Canga |
Citas:
---------- APA ----------
Canga, L., Gorelik, G. & Sterin-Borda, L. (1987) . Diabetes alters the reactivity of myocardium to a thromboxane analogue. Canadian Journal of Physiology and Pharmacology, 65(4), 499-503.http://dx.doi.org/10.1139/y87-085
---------- CHICAGO ----------
Canga, L., Gorelik, G., Sterin-Borda, L. "Diabetes alters the reactivity of myocardium to a thromboxane analogue" . Canadian Journal of Physiology and Pharmacology 65, no. 4 (1987) : 499-503.http://dx.doi.org/10.1139/y87-085
---------- MLA ----------
Canga, L., Gorelik, G., Sterin-Borda, L. "Diabetes alters the reactivity of myocardium to a thromboxane analogue" . Canadian Journal of Physiology and Pharmacology, vol. 65, no. 4, 1987, pp. 499-503.http://dx.doi.org/10.1139/y87-085
---------- VANCOUVER ----------
Canga, L., Gorelik, G., Sterin-Borda, L. Diabetes alters the reactivity of myocardium to a thromboxane analogue. CAN. J. PHYSIOL. PHARMACOL. 1987;65(4):499-503.http://dx.doi.org/10.1139/y87-085
