Artículo
Abstract:
The metabolism of [3H]noradrenaline by uterine horns from estrous, ovariectomized, and ovariectomized and estrogen-treated rats was explored. Uterine strips are able to take up [3H]noradrenaline and store it for up to 85 min after the isotope incubation. The major compounds retained in the tissue from rats either ovariectomized or during estrus were [3H]noradrenaline and 3H-labelled O-methylated deaminate metabolites. The [3H]3,4-dihydroxyphenylglycol ([3H]DOPEG) and 3,4-dihydroxymandelic acid ([3H]DOMA) fractions were higher in tissues from ovariectomized rats than during estrus. Ovariectomy also increased significantly spontaneous efflux of [3H]DOPEG and [3H]DOMA. The metabolic pattern of [3H]noradrenaline both in the tissue and in the efflux from ovariectomized rats was changed by estrogen treatment and became similar to those obtained during estrus. These data suggest a possible modulation of the noradrenaline metabolism by estrogens on the isolated rat uterus.
Registro:
| Documento: | Artículo |
| Título: | Metabolism of [3H]noradrenaline by the isolated rat uterus |
| Autor: | Fernandez-Pardal, J.; Gimeno, M.F.; Gimeno, A.L. |
| Filiación: | Cent. Estud. Farmacol. Principios Naturales, Consejo Nac. Invest. Ci. Tecn. Republica Argentina, 1428 Buenos Aires, Argentina |
| Palabras clave: | 3,4 dihydroxymandelic acid h 3; 3,4 dihydroxyphenylethylene glycol h 3; estradiol; estrogen; noradrenalin; noradrenalin h 3; radioisotope; unclassified drug; estradiol; estrogen; noradrenalin; animal experiment; endocrine system; estrus; female genital system; in vitro study; ovariectomy; pharmacokinetics; rat; uterus; animal; article; castration; estrus; female; metabolism; pregnancy; uterus; Animal; Castration; Estradiol; Estrogens; Estrus; Female; In Vitro; Norepinephrine; Pregnancy; Rats; Support, Non-U.S. Gov't; Uterus |
| Año: | 1981 |
| Volumen: | 59 |
| Número: | 12 |
| Página de inicio: | 1245 |
| Página de fin: | 1249 |
| DOI: | http://dx.doi.org/10.1139/y81-195 |
| Título revista: | Canadian Journal of Physiology and Pharmacology |
| Título revista abreviado: | CAN. J. PHYSIOL. PHARMACOL. |
| ISSN: | 00084212 |
| CODEN: | CJPPA |
| CAS: | estradiol, 50-28-2; noradrenalin, 1407-84-7, 51-41-2; Estradiol, 50-28-2; Estrogens; Norepinephrine, 51-41-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v59_n12_p1245_FernandezPardal |
Citas:
---------- APA ----------
Fernandez-Pardal, J., Gimeno, M.F. & Gimeno, A.L. (1981) . Metabolism of [3H]noradrenaline by the isolated rat uterus. Canadian Journal of Physiology and Pharmacology, 59(12), 1245-1249.http://dx.doi.org/10.1139/y81-195
---------- CHICAGO ----------
Fernandez-Pardal, J., Gimeno, M.F., Gimeno, A.L. "Metabolism of [3H]noradrenaline by the isolated rat uterus" . Canadian Journal of Physiology and Pharmacology 59, no. 12 (1981) : 1245-1249.http://dx.doi.org/10.1139/y81-195
---------- MLA ----------
Fernandez-Pardal, J., Gimeno, M.F., Gimeno, A.L. "Metabolism of [3H]noradrenaline by the isolated rat uterus" . Canadian Journal of Physiology and Pharmacology, vol. 59, no. 12, 1981, pp. 1245-1249.http://dx.doi.org/10.1139/y81-195
---------- VANCOUVER ----------
Fernandez-Pardal, J., Gimeno, M.F., Gimeno, A.L. Metabolism of [3H]noradrenaline by the isolated rat uterus. CAN. J. PHYSIOL. PHARMACOL. 1981;59(12):1245-1249.http://dx.doi.org/10.1139/y81-195
