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Menéndez-Helman, R.J.; Ferreyroa, G.V.; Dos Santos Afonso, M.; Salibián, A. "Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus" (2012) Bulletin of Environmental Contamination and Toxicology. 88(1):6-9
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Abstract:

The toxic effect of sublethal concentrations (1, 17.5 and 35 mg L -1) of pure glyphosate was evaluated on acetylcholinesterase (AChE) activity in the fish species, Cnesterodon decemmaculatus. Acute bioassays (96 h) under laboratory conditions were conducted and homogenates for each specimen corresponding to the anterior, middle and posterior body sections were performed. Fish survival was 100%, even at the highest concentration tested (35 mg L -1), in accordance with the low lethal toxicity reported for glyphosate. However, a significant inhibitory effect on AChE activity was recorded even for the lowest herbicide concentration tested (1 mg L -1), in the homogenates corresponding to the anterior body section. The inhibition ranged from 23 to 36%. The analytical determination of glyphosate in assay media by ion chromatography, was used to verify its stability. These results indicate that AChE-a neurotoxicity biomarker-in C. decemmaculatus may be affected by exposure to environmentally relevant concentrations of glyphosate. © 2011 Springer Science+Business Media, LLC.

Registro:

Documento: Artículo
Título:Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus
Autor:Menéndez-Helman, R.J.; Ferreyroa, G.V.; Dos Santos Afonso, M.; Salibián, A.
Filiación:INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria-Pabellón 2, C1428EHA Buenos Aires, Argentina
PRODEA-INEDES, Universidad Nacional de Luján, Luján B6700ZBA, Argentina
Academia Nacional de Farmacia y Bioquímica, Buenos Aires, Argentina
Palabras clave:AChE; Cnesterodon decemmaculatus; Glyphosate; Toxicity bioassay; Acetylcholinesterase; AChE; Analytical determination; Cnesterodon decemmaculatus; Fish species; Fish survival; Glyphosate; Glyphosates; Herbicide concentration; Inhibitory effect; Laboratory conditions; Neurotoxicity; Toxic effect; Bioassay; Toxicity; Herbicides; acetylcholinesterase; cholinesterase inhibitor; drug derivative; glycine; glyphosate; animal; article; Cyprinodontiformes; dose response; metabolism; physiology; water pollutant; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cyprinodontiformes; Dose-Response Relationship, Drug; Glycine; Water Pollutants, Chemical; Cnesterodon decemmaculatus
Año:2012
Volumen:88
Número:1
Página de inicio:6
Página de fin:9
DOI: http://dx.doi.org/10.1007/s00128-011-0423-8
Título revista:Bulletin of Environmental Contamination and Toxicology
Título revista abreviado:Bull. Environ. Contam. Toxicol.
ISSN:00074861
CODEN:BECTA
CAS:acetylcholinesterase, 9000-81-1; glycine, 56-40-6, 6000-43-7, 6000-44-8; glyphosate, 1071-83-6; Acetylcholinesterase, 3.1.1.7; Cholinesterase Inhibitors; Glycine, 56-40-6; Water Pollutants, Chemical; glyphosate, 1071-83-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00074861_v88_n1_p6_MenendezHelman

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Citas:

---------- APA ----------
Menéndez-Helman, R.J., Ferreyroa, G.V., Dos Santos Afonso, M. & Salibián, A. (2012) . Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus. Bulletin of Environmental Contamination and Toxicology, 88(1), 6-9.
http://dx.doi.org/10.1007/s00128-011-0423-8
---------- CHICAGO ----------
Menéndez-Helman, R.J., Ferreyroa, G.V., Dos Santos Afonso, M., Salibián, A. "Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus" . Bulletin of Environmental Contamination and Toxicology 88, no. 1 (2012) : 6-9.
http://dx.doi.org/10.1007/s00128-011-0423-8
---------- MLA ----------
Menéndez-Helman, R.J., Ferreyroa, G.V., Dos Santos Afonso, M., Salibián, A. "Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus" . Bulletin of Environmental Contamination and Toxicology, vol. 88, no. 1, 2012, pp. 6-9.
http://dx.doi.org/10.1007/s00128-011-0423-8
---------- VANCOUVER ----------
Menéndez-Helman, R.J., Ferreyroa, G.V., Dos Santos Afonso, M., Salibián, A. Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus. Bull. Environ. Contam. Toxicol. 2012;88(1):6-9.
http://dx.doi.org/10.1007/s00128-011-0423-8