Artículo
Bacman, S.; Borda, E.; Denduchi, B.; Lustig, L.; Sterin-Borda, L. "Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms" (1989) British Journal of Pharmacology. 97(2):377-382
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Abstract:
1. Antilaminin IgG decreased the dF/dt of mouse isolated atria and inhibited the mechanical effect of acetylcholine in a non-competitive fashion. 2. Inhibitors of nicotinic and muscarinic cholinoreceptors impaired the negative inotropic action of antilaminin IgG in mouse isolated atria. Hemicholinium and tetrodotoxin also reduced the response while the antihistamine, pyrilamine was without effect. 3. These results suggest that antilaminin IgG modulates cholinergic function in mouse isolated atria. Possible mechanisms are discussed.
Registro:
| Documento: | Artículo |
| Título: | Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms |
| Autor: | Bacman, S.; Borda, E.; Denduchi, B.; Lustig, L.; Sterin-Borda, L. |
| Filiación: | Centro de Estudios Farmacologicos y de Principios Naturales, 1414 Buenos Aires, Argentina |
| Palabras clave: | acetylcholine; antilaminin immunoglobulin g; atropine; cholinergic receptor; hemicholinium 3; hexamethonium; immunoglobulin G; mepyramine; unclassified drug; animal cell; drug concentration; heart atrium contractility; male; mouse; nonhuman; priority journal |
| Año: | 1989 |
| Volumen: | 97 |
| Número: | 2 |
| Página de inicio: | 377 |
| Página de fin: | 382 |
| DOI: | http://dx.doi.org/10.1111/j.1476-5381.1989.tb11964.x |
| Título revista: | British Journal of Pharmacology |
| Título revista abreviado: | BR. J. PHARMACOL. |
| ISSN: | 00071188 |
| CODEN: | BJPCB |
| CAS: | acetylcholine, 51-84-3, 60-31-1, 66-23-9; atropine, 51-55-8, 55-48-1; hemicholinium 3, 16478-59-4; hexamethonium, 60-26-4; immunoglobulin G, 97794-27-9; mepyramine, 6036-95-9, 91-84-9 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00071188_v97_n2_p377_Bacman |
Citas:
---------- APA ----------
Bacman, S., Borda, E., Denduchi, B., Lustig, L. & Sterin-Borda, L. (1989) . Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms. British Journal of Pharmacology, 97(2), 377-382.http://dx.doi.org/10.1111/j.1476-5381.1989.tb11964.x
---------- CHICAGO ----------
Bacman, S., Borda, E., Denduchi, B., Lustig, L., Sterin-Borda, L. "Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms" . British Journal of Pharmacology 97, no. 2 (1989) : 377-382.http://dx.doi.org/10.1111/j.1476-5381.1989.tb11964.x
---------- MLA ----------
Bacman, S., Borda, E., Denduchi, B., Lustig, L., Sterin-Borda, L. "Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms" . British Journal of Pharmacology, vol. 97, no. 2, 1989, pp. 377-382.http://dx.doi.org/10.1111/j.1476-5381.1989.tb11964.x
---------- VANCOUVER ----------
Bacman, S., Borda, E., Denduchi, B., Lustig, L., Sterin-Borda, L. Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms. BR. J. PHARMACOL. 1989;97(2):377-382.http://dx.doi.org/10.1111/j.1476-5381.1989.tb11964.x
