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Abstract:

Meningiomas are tumours derived from the arachnoid and pia mater. During embryogenesis, these membranes develop from the migrating craniofacial neural crest. We have previously demonstrated that meningiomas have characteristic features of embryonic meninges. Craniofacial neural crest derivatives are affected during normal development and migration by retinoic acid. We speculated, therefore, that meningioma cell migration and invasion would be affected in a similar way. In this study we investigated the mechanisms of invasion and migration in meningiomas and the effects of retinoic acid (RA). We found that low doses of RA inhibit in vitro invasion in meningioma cells, without affecting cell proliferation or viability. The matrix metalloproteinases MMP-2 (72 kDa gelatinase) and MMP-9 (92 kDa gelatinase), which play a key role in invasion in other tumours, are not affected by RA. RA inhibits cell migration on collagen I and fibronectin. A possible mechanism for these effects is provided by the fact that RA strongly stimulates adhesion of meningioma cells to extracellular matrix substrates. As in vitro invasion, migration and decreased adhesion to the extracellular matrix correlate with the clinical manifestation of tumour invasion, we conclude that RA induces a non-invasive phenotype in meningioma cells.

Registro:

Documento: Artículo
Título:Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion
Autor:Páez Pereda, M.; Hopfner, U.; Pagotto, U.; Renner, U.; Uhl, E.; Arzt, E.; Missale, C.; Stalla, G.K.
Filiación:Max-Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstr. 10, 80804 Munich, Germany
Department of Neurosurgery, University of Munich, Marchioninistr. 15, 81377 Munich, Germany
Lab. Fisiol./Biol. Molecular, Ciudad Universitaria Pabellon 2, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Dept. of Biomed. Sci./Biotechnology, Div. of Pharmacology, University of Brescia, Via Valsabbina 19, 25124 Brescia, Italy
Palabras clave:Cell adhesion; Meningioma; Retinoic acid; Tumour invasion; collagen type 1; fibronectin; gelatinase a; gelatinase b; matrix metalloproteinase; retinoic acid; article; cancer invasion; cell adhesion; cell proliferation; cell viability; controlled study; embryo development; extracellular matrix; human; human cell; meningioma; neural crest; phenotype; priority journal; Cell Adhesion; Cell Division; Collagenases; Culture Media, Conditioned; Extracellular Matrix; Gelatinases; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Meningeal Neoplasms; Meningioma; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Proteins; Tretinoin; Tumor Cells, Cultured
Año:1999
Volumen:81
Número:3
Página de inicio:381
Página de fin:386
DOI: http://dx.doi.org/10.1038/sj.bjc.6690705
Título revista:British Journal of Cancer
Título revista abreviado:Br. J. Cancer
ISSN:00070920
CODEN:BJCAA
CAS:Collagenases, EC 3.4.24.-; Culture Media, Conditioned; Gelatinases, EC 3.4.24.-; Matrix Metalloproteinase 2, EC 3.4.24.24; Matrix Metalloproteinase 9, EC 3.4.24.35; Metalloendopeptidases, EC 3.4.24.-; Neoplasm Proteins; Tretinoin, 302-79-4
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00070920_v81_n3_p381_PaezPereda.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00070920_v81_n3_p381_PaezPereda

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Citas:

---------- APA ----------
Páez Pereda, M., Hopfner, U., Pagotto, U., Renner, U., Uhl, E., Arzt, E., Missale, C.,..., Stalla, G.K. (1999) . Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion. British Journal of Cancer, 81(3), 381-386.
http://dx.doi.org/10.1038/sj.bjc.6690705
---------- CHICAGO ----------
Páez Pereda, M., Hopfner, U., Pagotto, U., Renner, U., Uhl, E., Arzt, E., et al. "Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion" . British Journal of Cancer 81, no. 3 (1999) : 381-386.
http://dx.doi.org/10.1038/sj.bjc.6690705
---------- MLA ----------
Páez Pereda, M., Hopfner, U., Pagotto, U., Renner, U., Uhl, E., Arzt, E., et al. "Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion" . British Journal of Cancer, vol. 81, no. 3, 1999, pp. 381-386.
http://dx.doi.org/10.1038/sj.bjc.6690705
---------- VANCOUVER ----------
Páez Pereda, M., Hopfner, U., Pagotto, U., Renner, U., Uhl, E., Arzt, E., et al. Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion. Br. J. Cancer. 1999;81(3):381-386.
http://dx.doi.org/10.1038/sj.bjc.6690705