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The effect of melatonin on in vivo γ-aminobutyric acid (GABA) accumulation in several brain regions was determined by measuring the increase of GABA levels following inhibition of GABA transaminase. A single melatonin injection (25-300 μg/kg) augmented significantly, by 17-20%, GABA accumulation in the hypothalamus and caused a dose-dependent increase of this parameter in the pineal gland. Significant rises of GABA accumulation were found in the cerebellum and cerebral cortex after administering 100-300 and 300 μg/kg of melatonin, respectively. © 1986.


Documento: Artículo
Título:Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland
Autor:Rosenstein, R.E.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales, CEFAPRIN, Buenos Aires, Argentina
Palabras clave:Cerebellum; Cerebral cortex; Hypothalamus; Melatonin; Pineal gland; γ-Aminobutyric acid (GABA); 4 amino 5 hexynoic acid; 4 aminobutyrate aminotransferase; 4 aminobutyric acid; melatonin; animal experiment; brain cortex; central nervous system; cerebellum; drug interaction; drug receptor binding; intraperitoneal drug administration; nonhuman; pineal body; priority journal; rat; 4-Aminobutyrate Transaminase; Aminocaproic Acids; Animal; Brain; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Hypothalamus; Male; Melatonin; Pineal Gland; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't
Página de inicio:403
Página de fin:406
Título revista:Brain Research
Título revista abreviado:Brain Res.
CAS:4 amino 5 hexynoic acid, 57659-38-8; 4 aminobutyrate aminotransferase, 9037-67-6; 4 aminobutyric acid, 28805-76-7, 56-12-2; melatonin, 73-31-4; 4-amino-5-hexynoic acid, 57659-38-8; 4-Aminobutyrate Transaminase, EC; Aminocaproic Acids; gamma-Aminobutyric Acid, 56-12-2; Melatonin, 73-31-4


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---------- APA ----------
Rosenstein, R.E. & Cardinali, D.P. (1986) . Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland. Brain Research, 398(2), 403-406.
---------- CHICAGO ----------
Rosenstein, R.E., Cardinali, D.P. "Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland" . Brain Research 398, no. 2 (1986) : 403-406.
---------- MLA ----------
Rosenstein, R.E., Cardinali, D.P. "Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland" . Brain Research, vol. 398, no. 2, 1986, pp. 403-406.
---------- VANCOUVER ----------
Rosenstein, R.E., Cardinali, D.P. Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland. Brain Res. 1986;398(2):403-406.