Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The effect of melatonin on in vivo γ-aminobutyric acid (GABA) accumulation in several brain regions was determined by measuring the increase of GABA levels following inhibition of GABA transaminase. A single melatonin injection (25-300 μg/kg) augmented significantly, by 17-20%, GABA accumulation in the hypothalamus and caused a dose-dependent increase of this parameter in the pineal gland. Significant rises of GABA accumulation were found in the cerebellum and cerebral cortex after administering 100-300 and 300 μg/kg of melatonin, respectively. © 1986.

Registro:

Documento: Artículo
Título:Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland
Autor:Rosenstein, R.E.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales, CEFAPRIN, Buenos Aires, Argentina
Palabras clave:Cerebellum; Cerebral cortex; Hypothalamus; Melatonin; Pineal gland; γ-Aminobutyric acid (GABA); 4 amino 5 hexynoic acid; 4 aminobutyrate aminotransferase; 4 aminobutyric acid; melatonin; animal experiment; brain cortex; central nervous system; cerebellum; drug interaction; drug receptor binding; intraperitoneal drug administration; nonhuman; pineal body; priority journal; rat; 4-Aminobutyrate Transaminase; Aminocaproic Acids; Animal; Brain; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Hypothalamus; Male; Melatonin; Pineal Gland; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't
Año:1986
Volumen:398
Número:2
Página de inicio:403
Página de fin:406
DOI: http://dx.doi.org/10.1016/0006-8993(86)91505-2
Título revista:Brain Research
Título revista abreviado:Brain Res.
ISSN:00068993
CODEN:BRREA
CAS:4 amino 5 hexynoic acid, 57659-38-8; 4 aminobutyrate aminotransferase, 9037-67-6; 4 aminobutyric acid, 28805-76-7, 56-12-2; melatonin, 73-31-4; 4-amino-5-hexynoic acid, 57659-38-8; 4-Aminobutyrate Transaminase, EC 2.6.1.19; Aminocaproic Acids; gamma-Aminobutyric Acid, 56-12-2; Melatonin, 73-31-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v398_n2_p403_Rosenstein

Referencias:

  • Acun˜a-Castroviejo, Lowenstein, Rosenstein, Cardinali, Diurnal rhythm of benzodiazepine binding in rat cerebral cortex: disruption by pinealectomy (1986) J. Pineal Res., 3, pp. 101-109
  • Acun˜a-Castroviejo, Rosenstein, Romeo, Cardinali, Changes in gamma-aminobutyric acid high affinity binding to cerebral cortex membranes after pinealectomy or melatonin administration to rats (1986) Neuroendocrinology, 43, pp. 24-31
  • Anton-Tay, Melatonin effects on brain function (1974) Adv Biochem Psychopharmacol, 11, pp. 315-324
  • Bernasconi, Bittiger, Heid, Martin, Determination of GABA levels by a3H muscimol radioreceptor assay (1980) J. Neurochem., 34, pp. 614-618
  • Bertilsson, Mao, Costa, Applications of principles of steady-state kinetics to the estimation of gamma aminobutyric acid turnover rate in nuclei of rat brain (1977) J. Pharmacol. Exp. Ther., 200, pp. 277-284
  • Cardinali, Vacas, Lowenstein, Melatonin action on brain: presumptive receptors and second messengers (1985) The Pineal Gland, Current State of Pineal Research, pp. 273-290. , B. Mess, Cs. Rúzsás, P. Pévet, Akadémiai Kiadó, Budapest
  • Ebadi, Regulation of the synthesis of melatonin and its significance to neuroendocrinology (1984) The Pineal Gland, pp. 1-37. , R.J. Reiter, Raven Press, New York
  • Elias, Valenta, Szekeres, Grossman, Regulatory role of gamma-aminobutyric acid in pituitary hormone secretion (1982) Psychoneuroendocrinology, 7, pp. 15-30
  • Goldman, The physiology of melatonin (1983) Pineal Research Reviews, 1, pp. 145-182. , R.J. Reiter, Alan R. Liss, New York
  • Gomes, Trolin, GABA turnover in mouse brain: agreement between the rate of GABA accumulation after aminooxyacetic acid and the rate of disappearance after 3-mercaptopropionic acid (1982) J. Neural Transm., 54, pp. 265-274
  • Graham, Aprison, Fluorimetric determination of aspartate glutamate and γ-aminobutyrate in nerve tissue using enzymic methods (1966) Analyt. Biochem., 15, pp. 487-497
  • Holloway, Grota, Brown, Immunohistochemical assessment of melatonin binding in the pineal gland (1985) J. Pineal Res., 2, pp. 235-251
  • Jung, Lippert, Metcalf, Schechter, Böhlen, Sjoerdsma, The effect of 4-amino-hex-5-ynoic acid (γ-acetylenic GABA, γ-ethynyl GABA), a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo (1977) J. Neurochem., 28, pp. 717-723
  • Karsch, Bittman, Foster, Goodman, Legan, Robinson, Neuroendocrine basis of seasonal reproduction (1984) Rec. Progr. Horm. Res., 40, pp. 185-222
  • Lindgren, Andén, Effect of the normal nerve impulse flow on the synthesis and utilization of GABA in the rat substantia nigra (1985) J. Neural Transm., 61, pp. 21-24
  • Lowenstein, Rosenstein, Cardinali, Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex (1985) Neurochem. Int., 7, pp. 675-681
  • Mata, Schrier, Klein, Weller, Chiou, On GABA function and physiology in the pineal gland (1976) Brain Research, 118, pp. 383-394
  • Niles, Pharmacologic effects of melatonin on acute stress-induced changes in brain γ-aminobutyric acid levels and receptors (1984) 14th Ann. Meet. Soc. Neurosci., , Anaheim, CA, Abstr. 329.12
  • Nir, Behroozi, Assael, Ivriani, Sulman, Changes in the electrical activity of the brain following pinealectomy (1968) Neuroendocrinology, 4, pp. 122-127
  • Philo, Reiter, Characterization of pinealectomy-induced convulsions in the Mongolian gerbil (Meriones unguiculatus) (1978) Epilepsia, 19, pp. 485-492
  • Racagni, Apud, Cocchi, Locatelli, Muller, GABAergic control of anterior pituitary hormone secretion (1982) Life Sci., 31, pp. 823-828
  • Reiter, Pineal gland: an intermediary between the environment and the endocrine system (1983) Psychoneuroendocrinology, 8, pp. 31-40
  • Romijn, The pineal, a tranquillizing organ? (1978) Life Sci., 23, pp. 2257-2274
  • Van der Heyden, Korf, Regional levels of GABA in the brain: rapid semiautomated assay and prevention of postmortal increase by 3-mercaptopropionic acid (1978) J. Neurochem., 31, pp. 197-203
  • Wurtman, Lieberman, Melatonin secretion as a mediator of circadian variations in sleep and sleepiness (1985) J. Pineal Res., 1, pp. 301-303

Citas:

---------- APA ----------
Rosenstein, R.E. & Cardinali, D.P. (1986) . Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland. Brain Research, 398(2), 403-406.
http://dx.doi.org/10.1016/0006-8993(86)91505-2
---------- CHICAGO ----------
Rosenstein, R.E., Cardinali, D.P. "Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland" . Brain Research 398, no. 2 (1986) : 403-406.
http://dx.doi.org/10.1016/0006-8993(86)91505-2
---------- MLA ----------
Rosenstein, R.E., Cardinali, D.P. "Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland" . Brain Research, vol. 398, no. 2, 1986, pp. 403-406.
http://dx.doi.org/10.1016/0006-8993(86)91505-2
---------- VANCOUVER ----------
Rosenstein, R.E., Cardinali, D.P. Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland. Brain Res. 1986;398(2):403-406.
http://dx.doi.org/10.1016/0006-8993(86)91505-2