Abstract:
Superior cervical ganglionectomy (SCG×) decreased significantly serum growth hormone (GH) levels in rats 14-96 h after surgery, during and immediately after anterograde degeneration of regional sympathetic terminals. At later times (up to 28 days after SCG×) an increase in serum GH was observed. SCG× augments prolactin (PRL) release, but only at the earliest time examined (14 h after surgery). Injection of the α-adrenoceptor blocker, phenoxybenzamine, but not of the β-blocker, propranolol, negated the depression in serum GH found in SCG× rats 14 h after surgery, without affecting PRL release. © 1986.
Registro:
Documento: |
Artículo
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Título: | Changes in growth hormone and prolactin release after superior cervical ganglionectomy of rats |
Autor: | Cardinali, D.P.; Boado, R.J.; Vacas, M.I.; Deza, S. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales, CEFAPRIN, CONICET, Buenos Aires, Argentina
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Palabras clave: | degeneration activity; growth hormone; noradrenaline; prolactin; superior cervical ganglion; α-adrenoceptor; β-adrenoceptor; adrenergic receptor; alpha adrenergic receptor; beta adrenergic receptor; growth hormone; phenoxybenzamine; prolactin; propranolol; animal experiment; autonomic nervous system; blood and hemopoietic system; drug comparison; drug efficacy; drug mechanism; endocrine system; ganglionectomy; hormone release; hypophysis; nonhuman; preliminary communication; priority journal; rat; subcutaneous drug administration; superior cervical ganglion; Animal; Ganglia, Sympathetic; Growth Hormone; Male; Phenoxybenzamine; Pituitary Gland, Anterior; Prolactin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't; Sympathectomy |
Año: | 1986
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Volumen: | 363
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Número: | 2
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Página de inicio: | 350
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Página de fin: | 353
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DOI: |
http://dx.doi.org/10.1016/0006-8993(86)91021-8 |
Título revista: | Brain Research
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Título revista abreviado: | Brain Res.
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ISSN: | 00068993
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CODEN: | BRREA
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CAS: | growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; phenoxybenzamine, 59-96-1, 63-92-3; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Growth Hormone, 9002-72-6; Phenoxybenzamine, 59-96-1; Prolactin, 9002-62-4; Propranolol, 525-66-6; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v363_n2_p350_Cardinali |
Referencias:
- Almgren, Dahlstrom, Ha¨ggendal, Degeneration secretion and noradrenaline disappearance in rat salivary glands following proximal or distal axotomy (1976) Acta Physiol. Scand., 98, pp. 457-464
- Arimura, Merchenthaler, Culler, Iwasak, Distribution and release of GRF (1984) Endocrinology, pp. 827-830. , F. Labrie, L. Prouxl, Elsevier, Amsterdam
- Cardinali, Ladizesky, Changes in parathyroid hormone release and calcium levels after superior cervical ganglionectomy of rats (1985) Neuroendocrinology, 40, pp. 291-296
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- Cardinali, Pisarev, Barontini, Juvenal, Boado, Vacas, Efferent neuroendocrine pathways of sympathetic superior cervical ganglia. Early depression of the pituitary-thyroid axis after ganglionectomy (1982) Neuroendocrinology, 35, pp. 248-254
- Cardinali, Vacas, Fortis, Stefano, Superior cervical ganglionectomy depresses norepinephrine uptake, increases the density of α-adrenergic sites, and induces supersensitivity to adrenergic drugs in rat medial basal hypothalamus (1981) Neuroendocrinology, 33, pp. 199-206
- Cella, Morgese, Mantegazza, Mu¨ller, Inhibitory action of theα1-adrenergic receptor on growthormone secretion in the dog (1984) Endocrinology, 114, pp. 2406-2408
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- Krulich, Central neurotransmitters and the secretion of prolactin, GH, Land TSH (1979) Annu. Rev. Physiol., 41, pp. 603-615
- Krulich, Mayfield, Steele, Millen, McCann, Koenig, Differential effects of pharmacological manipulations of centralα1andα2-adrenergic receptors on the secretion of thyrotropin and growthormone in male rats (1982) Endocrinology, 110, pp. 796-804
- Lipinska, Orlowska-Majdak, Traczyk, Oxytocin release from neurohypophysis evoked by preganglionic stimulation of the rat superior servical ganglion (1982) Endokrinologie, 79, pp. 385-392
- Martin, Brain regulation of Gsecretion (1976) Frontiers in Neuroendocrinology, 4, pp. 129-156. , L. Martini, W.F. Ganong, Raven Press, New York
- Nahmod, Balda, Pirola, Cardinali, Changes in plasma aldosterone and renin activity after bilateral superior cervical ganglionectomy in two strains of rats (1984) Acta Physiol. Pharmacol. Lat. Am., 34, pp. 263-269
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Citas:
---------- APA ----------
Cardinali, D.P., Boado, R.J., Vacas, M.I. & Deza, S.
(1986)
. Changes in growth hormone and prolactin release after superior cervical ganglionectomy of rats. Brain Research, 363(2), 350-353.
http://dx.doi.org/10.1016/0006-8993(86)91021-8---------- CHICAGO ----------
Cardinali, D.P., Boado, R.J., Vacas, M.I., Deza, S.
"Changes in growth hormone and prolactin release after superior cervical ganglionectomy of rats"
. Brain Research 363, no. 2
(1986) : 350-353.
http://dx.doi.org/10.1016/0006-8993(86)91021-8---------- MLA ----------
Cardinali, D.P., Boado, R.J., Vacas, M.I., Deza, S.
"Changes in growth hormone and prolactin release after superior cervical ganglionectomy of rats"
. Brain Research, vol. 363, no. 2, 1986, pp. 350-353.
http://dx.doi.org/10.1016/0006-8993(86)91021-8---------- VANCOUVER ----------
Cardinali, D.P., Boado, R.J., Vacas, M.I., Deza, S. Changes in growth hormone and prolactin release after superior cervical ganglionectomy of rats. Brain Res. 1986;363(2):350-353.
http://dx.doi.org/10.1016/0006-8993(86)91021-8