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Abstract:

The effect of several pineal methoxyindoles on 45Ca2+-uptake was examined in a crude synaptosome preparation from adult rat brains. 5-Methoxytryptol, 5-methoxytryptamine, melatonin and 6-chloromelatonin (10-8-10-6 M) depressed significantly the K+- stimulated increase in Ca2+-uptake, without affecting the basal, unstimulated Ca2+-uptake by synaptosomes. At 10-6 M concentration the following order of potency was found: 6-chloromelatonin ≥ 5-methoxytruptamine > 5-methoxytryptophol ≥ melatonin. Serotanin did not affect significantly either basal or stimulated Ca2+-uptake. © 1984.

Registro:

Documento: Artículo
Título:Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
Autor:Vacas, M.I.; Keller Sarmiento, M.I.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665/669, 1414 Buenos Aires, Argentina
Palabras clave:calcium uptake; melatonin; methoxyindoles; pineal gland; synaptosomes; 5 methoxytryptamine; 5 methoxytryptoline; 6 chloromelatonin; calcium; calcium chloride ca 45; melatonin; radioisotope; serotonin; animal cell; animal experiment; central nervous system; endocrine system; methoxyindole; nervous system; nonhuman; pineal body; rat; synaptosome; 5-Methoxytryptamine; Animal; Brain; Calcium; Female; In Vitro; Indoles; Melatonin; Pineal Gland; Rats; Rats, Inbred Strains; Serotonin; Support, Non-U.S. Gov't; Synaptosomes
Año:1984
Volumen:294
Número:1
Página de inicio:166
Página de fin:168
DOI: http://dx.doi.org/10.1016/0006-8993(84)91324-6
Título revista:Brain Research
Título revista abreviado:Brain Res.
ISSN:00068993
CODEN:BRREA
CAS:5 methoxytryptamine, 608-07-1, 66-83-1; 5 methoxytryptoline, 30439-19-1; 6 chloromelatonin, 63762-74-3; calcium chloride ca 45, 14336-71-1; calcium, 7440-70-2; melatonin, 73-31-4; serotonin, 50-67-9; 5-Methoxytryptamine, 608-07-1; 6-chloromelatonin, 63762-74-3; Calcium, 7440-70-2; Indoles; Melatonin, 73-31-4; methoxytryptophol, 712-09-4; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v294_n1_p166_Vacas

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Citas:

---------- APA ----------
Vacas, M.I., Keller Sarmiento, M.I. & Cardinali, D.P. (1984) . Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes. Brain Research, 294(1), 166-168.
http://dx.doi.org/10.1016/0006-8993(84)91324-6
---------- CHICAGO ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. "Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes" . Brain Research 294, no. 1 (1984) : 166-168.
http://dx.doi.org/10.1016/0006-8993(84)91324-6
---------- MLA ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. "Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes" . Brain Research, vol. 294, no. 1, 1984, pp. 166-168.
http://dx.doi.org/10.1016/0006-8993(84)91324-6
---------- VANCOUVER ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes. Brain Res. 1984;294(1):166-168.
http://dx.doi.org/10.1016/0006-8993(84)91324-6