Abstract:
Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluromelatonin (10-7 M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10-5 M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10-7 M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations. © 1981.
Registro:
Documento: |
Artículo
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Título: | Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
Autor: | Vacas, M.I.; Keller Sarmiento, M.I.; Cardinali, D.P. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), V. de Obligado 2490, 1428 Buenos Aires, Argentina
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Palabras clave: | 5-methoxytryptophol; cAMP; cGMP; medial basal hypothalamus; melatonin; pineal gland; 5 methoxytryptophol; 6 hydroxymelatonin; cyclic amp; cyclic gmp; melatonin; 6 fluoromelatonin; animal experiment; central nervous system; hypothalamus; in vitro study; nervous system; pineal body; rat; Animal; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Hypothalamus; Male; Melatonin; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't |
Año: | 1981
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Volumen: | 225
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Número: | 1
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Página de inicio: | 207
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Página de fin: | 211
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DOI: |
http://dx.doi.org/10.1016/0006-8993(81)90332-2 |
Título revista: | Brain Research
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Título revista abreviado: | Brain Res.
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ISSN: | 00068993
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CODEN: | BRREA
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CAS: | 5 methoxytryptophol, 712-09-4; 6 hydroxymelatonin, 2208-41-5; cyclic AMP, 60-92-4; cyclic GMP, 7665-99-8; melatonin, 73-31-4; Cyclic AMP, 60-92-4; Cyclic GMP, 7665-99-8; Melatonin, 73-31-4
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v225_n1_p207_Vacas |
Referencias:
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Citas:
---------- APA ----------
Vacas, M.I., Keller Sarmiento, M.I. & Cardinali, D.P.
(1981)
. Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro. Brain Research, 225(1), 207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2---------- CHICAGO ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P.
"Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro"
. Brain Research 225, no. 1
(1981) : 207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2---------- MLA ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P.
"Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro"
. Brain Research, vol. 225, no. 1, 1981, pp. 207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2---------- VANCOUVER ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro. Brain Res. 1981;225(1):207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2