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Abstract:

Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluromelatonin (10-7 M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10-5 M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10-7 M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations. © 1981.

Registro:

Documento: Artículo
Título:Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro
Autor:Vacas, M.I.; Keller Sarmiento, M.I.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:5-methoxytryptophol; cAMP; cGMP; medial basal hypothalamus; melatonin; pineal gland; 5 methoxytryptophol; 6 hydroxymelatonin; cyclic amp; cyclic gmp; melatonin; 6 fluoromelatonin; animal experiment; central nervous system; hypothalamus; in vitro study; nervous system; pineal body; rat; Animal; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Hypothalamus; Male; Melatonin; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't
Año:1981
Volumen:225
Número:1
Página de inicio:207
Página de fin:211
DOI: http://dx.doi.org/10.1016/0006-8993(81)90332-2
Título revista:Brain Research
Título revista abreviado:Brain Res.
ISSN:00068993
CODEN:BRREA
CAS:5 methoxytryptophol, 712-09-4; 6 hydroxymelatonin, 2208-41-5; cyclic AMP, 60-92-4; cyclic GMP, 7665-99-8; melatonin, 73-31-4; Cyclic AMP, 60-92-4; Cyclic GMP, 7665-99-8; Melatonin, 73-31-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v225_n1_p207_Vacas

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Citas:

---------- APA ----------
Vacas, M.I., Keller Sarmiento, M.I. & Cardinali, D.P. (1981) . Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro. Brain Research, 225(1), 207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2
---------- CHICAGO ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. "Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro" . Brain Research 225, no. 1 (1981) : 207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2
---------- MLA ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. "Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro" . Brain Research, vol. 225, no. 1, 1981, pp. 207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2
---------- VANCOUVER ----------
Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro. Brain Res. 1981;225(1):207-211.
http://dx.doi.org/10.1016/0006-8993(81)90332-2