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Abstract:

Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p<0.01) and of 45% in the D2R mRNA expression which involve short (p<0.05) and long (p<0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period. © 2004 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period
Autor:Soiza-Reilly, M.; Fossati, M.; Ibarra, G.R.; Azcurra, J.M.
Filiación:Lab. de Biología Celular, Fac. de Ciencias Exactas Y Naturales, Ciudad Universitaria (C1428EHA), Buenos Aires, Argentina
Biodiversidad Y Biol. Experimental, Universidad de Buenos Aires, C.F. Melo 4127, Buenos Aires 1602, Argentina
Palabras clave:Basal ganglia; Critical period; D1 receptor; D2 receptor; Dopamine; Motor plasticity; Motor systems and sensorimotor integration; Rat striatum; dopamine 1 receptor; dopamine 2 receptor; isoprotein; messenger RNA; muscarinic receptor; animal experiment; animal tissue; article; binding site; circling behavior; controlled study; corpus striatum; learning; male; motor activity; nonhuman; ontogeny; perinatal period; priority journal; protein binding; protein expression; rat; synapse; training; Animals; Corpus Striatum; Critical Period (Psychology); Gene Expression Regulation; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2
Año:2004
Volumen:1004
Número:1-2
Página de inicio:217
Página de fin:221
DOI: http://dx.doi.org/10.1016/j.brainres.2004.01.050
Título revista:Brain Research
Título revista abreviado:Brain Res.
ISSN:00068993
CODEN:BRREA
CAS:Receptors, Dopamine D1; Receptors, Dopamine D2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v1004_n1-2_p217_SoizaReilly

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Citas:

---------- APA ----------
Soiza-Reilly, M., Fossati, M., Ibarra, G.R. & Azcurra, J.M. (2004) . Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period. Brain Research, 1004(1-2), 217-221.
http://dx.doi.org/10.1016/j.brainres.2004.01.050
---------- CHICAGO ----------
Soiza-Reilly, M., Fossati, M., Ibarra, G.R., Azcurra, J.M. "Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period" . Brain Research 1004, no. 1-2 (2004) : 217-221.
http://dx.doi.org/10.1016/j.brainres.2004.01.050
---------- MLA ----------
Soiza-Reilly, M., Fossati, M., Ibarra, G.R., Azcurra, J.M. "Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period" . Brain Research, vol. 1004, no. 1-2, 2004, pp. 217-221.
http://dx.doi.org/10.1016/j.brainres.2004.01.050
---------- VANCOUVER ----------
Soiza-Reilly, M., Fossati, M., Ibarra, G.R., Azcurra, J.M. Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period. Brain Res. 2004;1004(1-2):217-221.
http://dx.doi.org/10.1016/j.brainres.2004.01.050