Artículo
Hesse, E.; Mikulan, E.; Decety, J.; Sigman, M.; Del Carmen Garcia, M.; Silva, W.; Ciraolo, C.; Vaucheret, E.; Baglivo, F.; Huepe, D.; Lopez, V.; Manes, F.; Bekinschtein, T.A.; Ibanez, A. "Early detection of intentional harm in the human amygdala" (2016) Brain. 139(1):54-61
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Abstract:
A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation. © The Author (2015).
Registro:
| Documento: | Artículo |
| Título: | Early detection of intentional harm in the human amygdala |
| Autor: | Hesse, E.; Mikulan, E.; Decety, J.; Sigman, M.; Del Carmen Garcia, M.; Silva, W.; Ciraolo, C.; Vaucheret, E.; Baglivo, F.; Huepe, D.; Lopez, V.; Manes, F.; Bekinschtein, T.A.; Ibanez, A. |
| Filiación: | Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology, Favaloro University, Buenos Aires, Argentina UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Universidad Diego Portales, Santiago, Chile Instituto de Ingeniería Biomédica, Facultad de Ingeniería, Universidad de Buenos Aires, Argentina National Research Council (CONICET), Buenos Aires, Argentina Department of Psychology, Department of Psychiatry and Behavioural Neuroscience, University of Chicago, Chicago, IL, United States Laboratory of Neuroscience, Universidad Torcuato Di Tella, Buenos Aires, Argentina Departamento de Física, FCEN, UBA, IFIBA, Conicet, Buenos Aires, Argentina Programa de Cirugía de Epilepsia, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina Escuela de Psicología, Pontificia Universidad Católica de Chile, Santiago, Chile Centre of Excellence in Cognition and its Disorders, Australian Research Council (ARC)NSW, Australia Department of Psychology, University of Cambridge, Cambridge, United Kingdom Universidad Autónoma del Caribe, Barranquilla, Colombia |
| Palabras clave: | Amygdala; Intentional harm; Intracranial recordings; Moral cognition; adult; amygdala; Article; case report; cognition; comparative study; connectome; controlled study; depth electrode; electric potential; electroencephalogram; electrophysiological procedures; eye tracking; female; frontal cortex; functional magnetic resonance imaging; functional neuroimaging; human; intentional harm; male; middle aged; morality; parietal cortex; priority journal; stimulus response; task performance; temporal cortex; young adult; aggression; amygdala; behavior; cognition; electrode implant; eye movement; morality; physiology; psychomotor performance; reproducibility; Adult; Aggression; Amygdala; Cognition; Electrodes, Implanted; Eye Movements; Female; Humans; Intention; Male; Middle Aged; Morals; Psychomotor Performance; Reproducibility of Results; Young Adult |
| Año: | 2016 |
| Volumen: | 139 |
| Número: | 1 |
| Página de inicio: | 54 |
| Página de fin: | 61 |
| DOI: | http://dx.doi.org/10.1093/brain/awv336 |
| Título revista: | Brain |
| Título revista abreviado: | Brain |
| ISSN: | 00068950 |
| CODEN: | BRAIA |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068950_v139_n1_p54_Hesse |
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Citas:
---------- APA ----------
Hesse, E., Mikulan, E., Decety, J., Sigman, M., Del Carmen Garcia, M., Silva, W., Ciraolo, C.,..., Ibanez, A. (2016) . Early detection of intentional harm in the human amygdala. Brain, 139(1), 54-61.http://dx.doi.org/10.1093/brain/awv336
---------- CHICAGO ----------
Hesse, E., Mikulan, E., Decety, J., Sigman, M., Del Carmen Garcia, M., Silva, W., et al. "Early detection of intentional harm in the human amygdala" . Brain 139, no. 1 (2016) : 54-61.http://dx.doi.org/10.1093/brain/awv336
---------- MLA ----------
Hesse, E., Mikulan, E., Decety, J., Sigman, M., Del Carmen Garcia, M., Silva, W., et al. "Early detection of intentional harm in the human amygdala" . Brain, vol. 139, no. 1, 2016, pp. 54-61.http://dx.doi.org/10.1093/brain/awv336
---------- VANCOUVER ----------
Hesse, E., Mikulan, E., Decety, J., Sigman, M., Del Carmen Garcia, M., Silva, W., et al. Early detection of intentional harm in the human amygdala. Brain. 2016;139(1):54-61.http://dx.doi.org/10.1093/brain/awv336
