Artículo

Manes, F.; Sahakian, B.; Clark, L.; Rogers, R.; Antoun, N.; Aitken, M.; Robbins, T. "Decision-making processes following damage to the prefrontal cortex" (2002) Brain. 125(3):624-639
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Abstract:

Recent work has suggested an association between the orbitofrontal cortex in humans and practical decision making. The aim of this study was to investigate the profile of cognitive deficits, with particular emphasis on decision-making processes, following damage to different sectors of the human prefrontal cortex. Patients with discrete orbitofrontal (OBF) lesions, dorsolateral (DL) lesions, dorsomedial (DM) lesions and large frontal lesions (Large) were compared with matched controls on three different decision-making tasks: the Iowa Gambling Task and two recently developed tasks that attempt to fractionate some of the cognitive components of the Iowa task. A comprehensive battery including the assessment of recognition memory, working memory, planning ability and attentional set-shifting was also administered. Whilst combined frontal patients were impaired on several of the tasks employed, distinct profiles emerged for each patient group. In contrast to previous data, patients with focal OBF lesions performed at control levels on the three decision-making tasks (and the executive tasks), but showed some evidence of prolonged deliberation. DL patients showed pronounced impairment on working memory, planning, attentional shifting and the Iowa Gambling Task. DM patients were impaired at the Iowa Gambling Task and also at planning. The Large group displayed diffuse impairment, but were the only group to exhibit risky decision making. Methodological differences from previous studies of OBF patient groups are discussed, with particular attention to lesion laterality, lesion size and psychiatric presentation. Ventral and dorsal aspects of prefrontal cortex must interact in the maintenance of rational and 'non-risky' decision making.

Registro:

Documento: Artículo
Título:Decision-making processes following damage to the prefrontal cortex
Autor:Manes, F.; Sahakian, B.; Clark, L.; Rogers, R.; Antoun, N.; Aitken, M.; Robbins, T.
Filiación:University of Cambridge, Psychiatry Department, Addenbrooke's Hospital, Cambridge, United Kingdom
Department of Radiology, Addenbrooke's Hospital, Cambridge, United Kingdom
Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
University of Cambridge, Psychiatry Department, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
Cognitive Neurology Division, Department of Neurology, Raul Carrea Institute of Neurological Research, Montañeses 2325, (1428) Buenos Aires, Argentina
Palabras clave:Decision making; Executive function; Orbitofrontal; Prefrontal cortex; Risk taking; adult; aged; article; brain function; brain injury; clinical article; cognitive defect; decision making; female; human; male; neuropsychological test; neuroradiology; prefrontal cortex; priority journal; recognition; risk assessment; stimulus response; task performance; wellbeing; working memory
Año:2002
Volumen:125
Número:3
Página de inicio:624
Página de fin:639
DOI: http://dx.doi.org/10.1093/brain/awf049
Título revista:Brain
Título revista abreviado:Brain
ISSN:00068950
CODEN:BRAIA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068950_v125_n3_p624_Manes

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Citas:

---------- APA ----------
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M. & Robbins, T. (2002) . Decision-making processes following damage to the prefrontal cortex. Brain, 125(3), 624-639.
http://dx.doi.org/10.1093/brain/awf049
---------- CHICAGO ----------
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., et al. "Decision-making processes following damage to the prefrontal cortex" . Brain 125, no. 3 (2002) : 624-639.
http://dx.doi.org/10.1093/brain/awf049
---------- MLA ----------
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., et al. "Decision-making processes following damage to the prefrontal cortex" . Brain, vol. 125, no. 3, 2002, pp. 624-639.
http://dx.doi.org/10.1093/brain/awf049
---------- VANCOUVER ----------
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., et al. Decision-making processes following damage to the prefrontal cortex. Brain. 2002;125(3):624-639.
http://dx.doi.org/10.1093/brain/awf049