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Abstract:

BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro-or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G′ (storage modulus) values. The C-C stretch and the CH2 rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C-C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer-polymer and/or polymer-polymer-actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups. © 2014-IOS Press and the authors.

Registro:

Documento: Artículo
Título:Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
Autor:Tosato, M.G.; Orallo, D.E.; Churio, M.S.; Martin, A.A.; Soto, C.A.T.; Dicelio, L.E.
Filiación:Universidad de Buenos Aires, INQUIMAE, Buenos Aires, Argentina
Facultad de Ciencias Exactas, Universidad Nacional de Mar Del Plata, Mar del Plata, Argentina
Laboratório de Espectroscopia Vibracional Biomédica, Universidade Do Vale Do Paraíba, Sao José dos Campos, Brazil
Palabras clave:gadusol; mycosporine-like amino acids; Triblock copolymers; viscoelastic; amino acid derivative; antioxidant; gadusol; poloxamer; porphyra 334; shinorine; unclassified drug; amino acid; antioxidant; carbon; cyclohexanol derivative; cyclohexanone derivative; cyclohexylamine derivative; gadusol; gel; glycine; polymer; porphyra-334; shinorine; antioxidant activity; Article; chemical structure; conformational transition; controlled study; covalent bond; cross linking; female; flow kinetics; gel; gelation; hydrophilicity; molecular weight; nonhuman; Porphyra; Raman spectrometry; tensile strength; viscosity; analogs and derivatives; chemistry; flow kinetics; gel; pH; procedures; temperature; vibration; Amino Acids; Antioxidants; Carbon; Cyclohexanols; Cyclohexanones; Cyclohexylamines; Gels; Glycine; Hydrogen-Ion Concentration; Poloxamer; Polymers; Rheology; Spectrum Analysis, Raman; Temperature; Vibration; Viscosity
Año:2014
Volumen:51
Número:4-5
Página de inicio:315
Página de fin:328
DOI: http://dx.doi.org/10.3233/BIR-14014
Título revista:Biorheology
Título revista abreviado:Biorheology
ISSN:0006355X
CODEN:BRHLA
CAS:poloxamer, 9003-11-6; amino acid, 65072-01-7; carbon, 7440-44-0; glycine, 56-40-6, 6000-43-7, 6000-44-8; Amino Acids; Antioxidants; Carbon; Cyclohexanols; Cyclohexanones; Cyclohexylamines; gadusol; Gels; Glycine; Poloxamer; Polymers; porphyra-334; shinorine
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006355X_v51_n4-5_p315_Tosato

Referencias:

  • Antunes, F.E., Gentile, L., Rossi, C.O., Tavano, L., Ranieri, G.A., Gels of Pluronic F127 and nonionic surfactants from rheologicalcharacterization to controlled drug permeation (2011) Colloids and Surfaces B: Biointerfaces., 87 (1), pp. 42-48
  • Correâ, N.M., Camargo, F.B., Jr., Ignácio, R.F., Leonardi, G.R., Avaliacąo do comportamento reológico de diferentes geís hidrofílicos (2005) Brazilian J Pharm Sciences., 41 (1), pp. 73-78
  • Moreira, T.S., Sousa, V.P., Pierre, M.B.R., Influence of oleic acid on the rheology and in vitro release of lumiracoxib frompoloxamer gels (2010) Journal of Pharmacy & Pharmaceutical Sciences., 13 (2), pp. 286-302
  • Escobar-Chávez, J.J., Quintanar-Guerrero, D., Ganem-Quintanar, A., In vivo skin permeation of sodium naproxen formulatedin Pluronic F-127 gels: Effect of Azone and Transcutol (2005) Drug Dev Ind Pharm., 31, pp. 447-454
  • Veyries, M.L., Couarraze, G., Geiger, S., Agnely, F., Massias, L., Kunzli, B., Controlled release of vancomycin fromPoloxamer 407 gels (1999) Int J Pharm., 192 (2), pp. 183-193
  • Escobar-Chávez, J.J., López-Cervantes, M., Naik, A., Kalia, Y.N., Quintanar-Gerrero, D., Ganem-Quintanar, A., Applications ofthermo-reversible Pluronic F-127 gels in pharmaceutical formulations (2006) Journal of Pharmacy & Pharmaceutical Sciences., 9 (3), pp. 339-358
  • Kaminski, G.A.T., Silverio, L.C., Pasqualim, P., Fin, M.T., Sasso, D.G.B., Fujiwara, G.M., Evaluation of oil variability andits influence on hydrophilic low molecular weight drugs microencapsulation by w/o emulsification (2010) Visao Acadêmica, 11 (1), pp. 45-54
  • Djabri, A., Guy, R.H., Delgado-Charro, M.B., Transdermal iontophoresis of ranitidine: An opportunity in paediatric drugtherapy (2012) Int J Pharm., 435 (1), pp. 27-32
  • Singh, S., Gajra, B., Rawat, M., Muthu, M.S., Enhanced transdermal delivery of ketoprofen from bioadhesive gels (2009) PakistanJournal of Pharmaceutical Sciences., 22 (2), pp. 193-198
  • Son, Y.J., Yoo, H.S., Dexamethasone-incorporated nanofibrous meshes for antiproliferation of smooth muscle cells: Thermallyinduced drug-loading strategy (2012) Journal of Biomedical Materials Research Part A., 100 (10), pp. 2678-2685
  • Chiheb, I., Riadi Hmartinez-Lopez, J., Dominguez Seglar, J.F., Vidal, J.A.G., Bouziane, H., Screening of antibacterial activityin marine green and brown macroalgae from the coast ofMorocco (2009) African Journal of Biotechnology., 8 (7), pp. 1258-1262
  • De La Coba, F., Aguilera, J., De Gálvez, M.V., Álvarez, M., Gallego, E., Figueroa, F.L., Prevention of the ultraviolet effects onclinical and histopathological changes as well as the heat shock protein-70 expression in mouse skin by topical applicationof algal UV-absorbing compounds (2009) Journal of Dermatological Science., 55 (3), pp. 161-169
  • De La Coba, F., Aguilera, J., Figueroa, F.L., Gálvez, M.V., Herrera, E., Antioxidant activity of mycosporine-like amino acidsisolated from three red macroalgae and one marine lichen (2008) Journal of Applied Phycology., 21 (2), pp. 161-169
  • Shick, J.M., Dunlap, W.C., Mycosporine-like amino acids and related gadusols: Biosynthesis accumulation, and UVprotectivefunctions in aquatic organisms (2002) Annual Review of Physiology., 64 (1), pp. 223-262. , thesis
  • Garciá-Abuín, A., Gómez-Diáz, D., Navaza, J.M., Regueiro, L., Vidal-Tato, I., Viscosimetric behaviour of hyaluronic acid indifferent aqueous solutions (2011) Carbohydrate Polymers., 85 (3), pp. 500-505
  • Lorenzo, G., Zaritzky, N., Califano, A., Rheological analysis of emulsion-filled gels based on high acyl gellan gum (2013) FoodHydrocolloids., 30 (2), pp. 672-680
  • Farquharson, S., Smith, W., Rose, J., Shaw, M., Correlations between molecular (Raman) and macroscopic (rheology) data forprocess monitoring of thermoset composites (2002) JPAC Process Analytical Chemistry., pp. 45-53
  • Liu, J., Chen, G., Jiang, M., Supramolecular hybrid hydrogels from noncovalently functionalized graphene with block copolymers (2011) Macromolecules., 44, pp. 7682-7691
  • Conde, F.R., Churio, M.S., Previtali, C.M., The photoprotector mechanism of mycosporine-like amino acids. Excited-stateproperties and photostability of porphyra-334 in aqueous solution (2000) Journal of Photochemistry and Photobiology B: Biology., 56 (2-3), pp. 139-144
  • Conde, F.R., Churio, M.S., Previtali, C.M., The deactivation pathways of the excited-states of the mycosporine-like amino acidsshinorine and porphyra-334 in aqueous solution (2004) Photochemical & Photobiological Sciences., 3, pp. 960-967
  • Plack, P.A., Fraser, N.W., Grant, P.T., Middleton, C., Mitchell, A.I., Thomsont, R.H., Gadusol, an enolic derivative of cyclohexane-1,3-dione present in the roes of cod and other marine fish (1981) Biochemist Journal., 199, pp. 741-747
  • Bandaranayake, W.M., Bourne, D.J., Sim, R.G., Chemical composition during maturing and spawning of the Sponge Dysideaherbacea (Porifera: Demospongiae (1997) Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology., 118 (4), pp. 851-859
  • Arbeloa, E.M., Uez, M.J., Bertolotti, S.G., Churio, M.S., Antioxidant activity of gadusol and occurrence in fish roes from ArgentineSea (2010) Food Chemistry., 119 (2), pp. 586-591
  • Schmolka, I.R., A review of block polymer surfactants (1977) Journal of the American Oil Chemists' Society., 54 (3), pp. 110-116
  • Malmsten, M., Soft drug delivery systems (2006) Soft Matter., 2, pp. 760-769
  • Šturcová A, S., Role of hydration and water coordination in micellization of pluronic block copolymers (2010) Journal of Colloid and Interface Science., 352 (2), pp. 415-423
  • Chrit, L., Hadjur, C., Morel, S., Sockalingum, G., Lebourdon, G., Leroy, F., In vivo chemical investigation of human skinusing a confocal Raman fiber optic microprobe (2005) Journal of Biomedical Optics., 10 (4), p. 44007
  • Brookes, A., Dyke, J.M., Hendra, P.J., Meehan, S., The FT-Raman spectroscopic study of polymers at temperatures in excessof 200°C (1997) Spectrochimica Acta Part A., 53, pp. 2313-2321
  • Fukuhara, K., Sagawa, T., Kihara, S., Matsuura, H., Extended oxyethylene chain in triblock compounds al-octyl-woctyloxyoligo(oxyethylene)s studied by Raman spectroscopy (1996) Journal of Molecular Structure., 379, pp. 197-204
  • O'Faolaion, E., Hunter, M., Byrne, J., Kellehan, P., McNamara, M., A study examining the effects of tissue processing on humantissue sections using vibrational spectroscopy (2005) Materials Synthesis and Applications, , Dublin Institute of Technology
  • Edwards, H.G.M., Garcia-Pichel, F., Newton, E.M., Wynn-Williams, D.D., Vibrational Raman spectroscopic study of scytoneminthe UV-protective cyanobacterial pigment (2000) Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 56 (1), pp. 193-200
  • Gunasekaran, S., Sailatha, E., Seshadri, S., Kumaresan, S., FTIR, FT Raman spectra and molecular structural confirmation ofisoniazid (2009) Indian Journal of Pure & Applied Physics., 47, pp. 12-18. , January
  • Guo, C., Liu, H., Wang, J., Chen, J., Conformational structure of triblock copolymers by FT-Raman and FTIR spectroscopy (1999) Journal of Colloid and Interface Science., 209 (2), pp. 368-373
  • Larkin, P., (2011) Correlations: Characteristic Group Frequencies, pp. 73-115. , San Diego USA: Elsevier
  • Movasaghi, Z., Rehman, S., Rehman, I.U., Raman spectroscopy of biological tissues (2007) Applied Spectroscopy Reviews., 42 (5), pp. 493-541
  • Winter, H.H., Mours, M., (1997) Advances in Polymer Science, pp. 165-234. , Dusek K editor. Amherst, USA: Springer;
  • Alvarez-Román, R., Naik, A., Kalia, Y.N., Guy, R.H., Fessi, H., Skin penetration and distribution of polymeric nanoparticles (2004) Journal of Controlled Release., 99 (1), pp. 53-62
  • Wang, J.-Y., Marks, J., Lee, K.Y.C., Nature of interactions between PEO-PPO-PEO triblock copolymers and lipid membranes: I) effect of polymer hydrophobicity on its ability to protect liposomes from peroxidation (2012) Biomacromolecules, 13 (9), pp. 2624-2633
  • Steffe, J.F., (1996) Rheological Methods in Food Process Engineering. 2nd Ed, pp. 294-349. , East Lansing MI: Freeman Press; Chapter 5,Viscoelasticity;
  • Rao, M.A., (2007) Rheology of Fluid and Semisolid Foods: Principles and Applications. 2nd Ed, , Geneva NY USA: Springer;
  • Hsu, S., Lu, S., Huang, C., Viscoelastic changes of rice starch suspensions during gelatinization (2000) JFS: Food Chemistry AndToxicology., 65 (2), pp. 215-220
  • Lee, D.C., Chapman, D., Infrared spectroscopic studies of biomembranes and model membranes (1986) Bioscience Reports., 6 (3), pp. 235-256
  • Wong, P.T.T., Murphy, W.F., Mantsch, H.H., Pressure effects on the Raman spectra of phospholipid membranes: Pressure inducedphase transitions and structural changes in 1,2-dimyristoyl 3-sn-phosphatidylcholine water dispersions (1982) The Journalof Chemical Physics., 76 (11), p. 5230
  • Chai, C.K., Dixon, N.M., Gerrard, D.L., Reed, W., Rheo-Raman studies of polyethylene melts (1995) Polymer., 36 (3), pp. 661-663
  • Maria Do Carmo, B.V., (2003) Caracterizacąo da Viscosidade Aparente No Estado Semi-sólido e das Propriedades Mecanicas da ligaAA7075, , http://hdl.handle.net/10183/7894, Available from
  • Guo, C., Wang, J., Liu, H.-Z., Chen, J.-Y., Hydration and conformation of temperature-dependent micellization of PEO-PPO-PEO block copolymers in aqueous solutions by FT-Raman (1999) Langmuir., 15 (22), pp. 2703-2708

Citas:

---------- APA ----------
Tosato, M.G., Orallo, D.E., Churio, M.S., Martin, A.A., Soto, C.A.T. & Dicelio, L.E. (2014) . Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels. Biorheology, 51(4-5), 315-328.
http://dx.doi.org/10.3233/BIR-14014
---------- CHICAGO ----------
Tosato, M.G., Orallo, D.E., Churio, M.S., Martin, A.A., Soto, C.A.T., Dicelio, L.E. "Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels" . Biorheology 51, no. 4-5 (2014) : 315-328.
http://dx.doi.org/10.3233/BIR-14014
---------- MLA ----------
Tosato, M.G., Orallo, D.E., Churio, M.S., Martin, A.A., Soto, C.A.T., Dicelio, L.E. "Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels" . Biorheology, vol. 51, no. 4-5, 2014, pp. 315-328.
http://dx.doi.org/10.3233/BIR-14014
---------- VANCOUVER ----------
Tosato, M.G., Orallo, D.E., Churio, M.S., Martin, A.A., Soto, C.A.T., Dicelio, L.E. Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels. Biorheology. 2014;51(4-5):315-328.
http://dx.doi.org/10.3233/BIR-14014