Artículo
Abstract:
Testosterone metabolism, androgen receptors, and the androgen binding protein (ABP) were studied male albino rats injected wit 1 mg of testosterone propionate (TP) on Day 2 of life. The epididymal content of ABP was diminished inmmature but not in adult animals treated neonatally with androgen. No changes were detected in the testicular levels of this protein in 27-day-old rats. In adult animals atrophic lesions were seen in 3% of the seminiferous tubules. Androgen treatment of neonates led to a substantial decrease in the 5α-reductase activity in homogenates of prostate gland and epididymis from adult rats with a concomitant decline in the 3α-β-hydroxysteroid dehydrogenase activities in both tissues. These animals did not show any change in the number of available or total androgen receptor sites as measured by incubating prostatic cytosol with [3H]R1881. The present findings suggest that the impaired development of the male genital tract could be partially due to diminished peripheral conversion of testosterone to its active, 5α-reduced metabolites.
Registro:
| Documento: | Artículo |
| Título: | Effects of androgen treatment of the neonate on rat testis and sex accessory organs |
| Autor: | Baranao, J.L.; Chemes, H.E.; Tesone, M.; Chiauzzi, V.A.; Scacchi, P.; Calvo, J.C.; Faigon, M.R.; Moguilevsky, J.A.; Charreau, E.H.; Calandra, R.S. |
| Filiación: | Inst. Biol. Med. Exp., Buenos Aires 1428, Argentina |
| Palabras clave: | 5alpha androstane 3alpha,17beta diol c 14; androgen binding protein; androgen receptor; androstanolone h 3; enzyme; methyltrienolone h 3; radioisotope; steroid reductase; testosterone; testosterone h 3; testosterone propionate; unclassified drug; age; animal experiment; article; endocrine system; epididymis; histology; hormone metabolism; male genital system; newborn; prostate; rat; sex accessory organ; sexual development; subcutaneous drug administration; testis; Animalia |
| Año: | 1981 |
| Volumen: | 25 |
| Número: | 4 |
| Página de inicio: | 851 |
| Página de fin: | 858 |
| DOI: | http://dx.doi.org/10.1095/biolreprod25.4.851 |
| Título revista: | Biology of Reproduction |
| Título revista abreviado: | BIOL. REPROD. |
| ISSN: | 00063363 |
| CODEN: | BIREB |
| CAS: | steroid reductase, 42616-29-5, 9082-73-9; testosterone, 58-22-0; testosterone propionate, 57-85-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063363_v25_n4_p851_Baranao |
Citas:
---------- APA ----------
Baranao, J.L., Chemes, H.E., Tesone, M., Chiauzzi, V.A., Scacchi, P., Calvo, J.C., Faigon, M.R.,..., Calandra, R.S. (1981) . Effects of androgen treatment of the neonate on rat testis and sex accessory organs. Biology of Reproduction, 25(4), 851-858.http://dx.doi.org/10.1095/biolreprod25.4.851
---------- CHICAGO ----------
Baranao, J.L., Chemes, H.E., Tesone, M., Chiauzzi, V.A., Scacchi, P., Calvo, J.C., et al. "Effects of androgen treatment of the neonate on rat testis and sex accessory organs" . Biology of Reproduction 25, no. 4 (1981) : 851-858.http://dx.doi.org/10.1095/biolreprod25.4.851
---------- MLA ----------
Baranao, J.L., Chemes, H.E., Tesone, M., Chiauzzi, V.A., Scacchi, P., Calvo, J.C., et al. "Effects of androgen treatment of the neonate on rat testis and sex accessory organs" . Biology of Reproduction, vol. 25, no. 4, 1981, pp. 851-858.http://dx.doi.org/10.1095/biolreprod25.4.851
---------- VANCOUVER ----------
Baranao, J.L., Chemes, H.E., Tesone, M., Chiauzzi, V.A., Scacchi, P., Calvo, J.C., et al. Effects of androgen treatment of the neonate on rat testis and sex accessory organs. BIOL. REPROD. 1981;25(4):851-858.http://dx.doi.org/10.1095/biolreprod25.4.851
