Artículo

Rocchetti, J.; Isingrini, E.; Dal Bo, G.; Sagheby, S.; Menegaux, A.; Tronche, F.; Levesque, D.; Moquin, L.; Gratton, A.; Wong, T.P.; Rubinstein, M.; Giros, B. "Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus" (2015) Biological Psychiatry. 77(6):513-525
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Abstract:

Background Dysfunctional mesocorticolimbic dopamine signaling has been linked to alterations in motor and reward-based functions associated with psychiatric disorders. Converging evidence from patients with psychiatric disorders and use of antipsychotics suggests that imbalance of dopamine signaling deeply alters hippocampal functions. However, given the lack of full characterization of a functional mesohippocampal pathway, the precise role of dopamine transmission in memory deficits associated with these disorders and their dedicated therapies is unknown. In particular, the positive outcome of antipsychotic treatments, commonly antagonizing D 2 dopamine receptors (D2Rs), on cognitive deficits and memory impairments remains questionable. Methods Following pharmacologic and genetic manipulation of dopamine transmission, we performed anatomic, neurochemical, electrophysiologic, and behavioral investigations to uncover the role of D2Rs in hippocampal-dependent plasticity and learning. Naïve mice (n = 4-21) were used in the different procedures. Results Dopamine modulated both long-term potentiation and long-term depression in the temporal hippocampus as well as spatial and recognition learning and memory in mice through D2Rs. Although genetic deletion or pharmacologic blockade of D2Rs led to the loss of long-term potentiation expression, the specific genetic removal of presynaptic D2Rs impaired long-term depression and performances on spatial memory tasks. Conclusions Presynaptic D2Rs in dopamine fibers of the temporal hippocampus tightly modulate long-term depression expression and play a major role in the regulation of hippocampal learning and memory. This direct role of mesohippocampal dopamine input as uncovered here adds a new dimension to dopamine involvement in the physiology underlying deficits associated with neuropsychiatric disorders. © 2015 Society of Biological Psychiatry.

Registro:

Documento: Artículo
Título:Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus
Autor:Rocchetti, J.; Isingrini, E.; Dal Bo, G.; Sagheby, S.; Menegaux, A.; Tronche, F.; Levesque, D.; Moquin, L.; Gratton, A.; Wong, T.P.; Rubinstein, M.; Giros, B.
Filiación:Department of Psychiatry, Douglas Mental Health University Institute, McGill University, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada
Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche en Santé 1130, France
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8246, Sorbonne University Université Pierre et Marie Curie, Paris, France
Département de Pharmacie, Université de Montréal, Montreal, QC, Canada
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Instituto de Investigaciones en Ingenieria Genética y Biologia Molecular (CONICET), Universidad de Buenos Aires, Argentina
Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:Antipsychotics; D 2 dopamine receptors; LTD; Memory; Neuronal plasticity; Temporal hippocampus; dopamine; dopamine 2 receptor; presynaptic receptor; dopamine 2 receptor; dopamine 2 receptor blocking agent; DRD2 protein, mouse; messenger RNA; animal experiment; animal tissue; Article; brain electrophysiology; cognitive defect; controlled study; dopaminergic transmission; gene expression; hippocampal CA1 region; hippocampus; long term depression; long term potentiation; male; memory disorder; mouse; nerve cell plasticity; neuroanatomy; neurochemistry; neuromodulation; nonhuman; priority journal; regulatory mechanism; spatial learning; spatial memory; task performance; animal; C57BL mouse; depth perception; drug effects; excitatory postsynaptic potential; genetics; hippocampus; learning; long term depression; memory; metabolism; nerve tract; physiology; transgenic mouse; ventral tegmentum; Animals; Dopamine D2 Receptor Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Learning; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Memory; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Receptors, Dopamine D2; RNA, Messenger; Space Perception; Ventral Tegmental Area
Año:2015
Volumen:77
Número:6
Página de inicio:513
Página de fin:525
DOI: http://dx.doi.org/10.1016/j.biopsych.2014.03.013
Título revista:Biological Psychiatry
Título revista abreviado:Biol. Psychiatry
ISSN:00063223
CODEN:BIPCB
CAS:dopamine, 51-61-6, 62-31-7; Dopamine D2 Receptor Antagonists; DRD2 protein, mouse; Receptors, Dopamine D2; RNA, Messenger
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063223_v77_n6_p513_Rocchetti

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Citas:

---------- APA ----------
Rocchetti, J., Isingrini, E., Dal Bo, G., Sagheby, S., Menegaux, A., Tronche, F., Levesque, D.,..., Giros, B. (2015) . Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus. Biological Psychiatry, 77(6), 513-525.
http://dx.doi.org/10.1016/j.biopsych.2014.03.013
---------- CHICAGO ----------
Rocchetti, J., Isingrini, E., Dal Bo, G., Sagheby, S., Menegaux, A., Tronche, F., et al. "Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus" . Biological Psychiatry 77, no. 6 (2015) : 513-525.
http://dx.doi.org/10.1016/j.biopsych.2014.03.013
---------- MLA ----------
Rocchetti, J., Isingrini, E., Dal Bo, G., Sagheby, S., Menegaux, A., Tronche, F., et al. "Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus" . Biological Psychiatry, vol. 77, no. 6, 2015, pp. 513-525.
http://dx.doi.org/10.1016/j.biopsych.2014.03.013
---------- VANCOUVER ----------
Rocchetti, J., Isingrini, E., Dal Bo, G., Sagheby, S., Menegaux, A., Tronche, F., et al. Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus. Biol. Psychiatry. 2015;77(6):513-525.
http://dx.doi.org/10.1016/j.biopsych.2014.03.013