Artículo

Romano, A.; Locatelli, F.; Freudenthal, R.; Merlo, E.; Feld, M.; Ariel, P.; Lemos, D.; Federman, N.; Fustiñana, M.S. "Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus" (2006) Biological Bulletin. 210(3):280-288
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Abstract:

Consolidation of long-term memory requires the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to regulation of gene expression, both of which promote stabilization of specific changes in the activated circuits. In search of the molecular mechanisms involved in such processes, we used the context-signal associative learning paradigm of the crab Chasmagnathus. In this model, we studied the role of some molecular mechanisms, namely cAMP-dependent protein kinase (PKA), extracellular-signal-regulated kinase (ERK), the nuclear factor kappa B (NF-κB) transcription factor, and the role of synaptic proteins such as amyloid β precursor protein, with the object of describing key mechanisms involved in memory processing. In this article we review the most salient results obtained over a decade of research in this memory model. © 2006 Marine Biological Laboratory.

Registro:

Documento: Artículo
Título:Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus
Autor:Romano, A.; Locatelli, F.; Freudenthal, R.; Merlo, E.; Feld, M.; Ariel, P.; Lemos, D.; Federman, N.; Fustiñana, M.S.
Filiación:Departamento de Fisiología, Biología Molecular y Celular, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:amyloid precursor protein; cyclic AMP dependent protein kinase; immunoglobulin enhancer binding protein; mitogen activated protein kinase; crab; enzyme activity; gene expression; memory; protein; animal; animal model; biological model; Brachyura; memory; metabolism; physiology; review; signal transduction; synaptic transmission; Amyloid beta-Protein Precursor; Animals; Brachyura; Cyclic AMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Memory; Models, Animal; Models, Neurological; NF-kappa B; Signal Transduction; Synaptic Transmission; Chasmagnathus; Decapoda (Crustacea)
Año:2006
Volumen:210
Número:3
Página de inicio:280
Página de fin:288
DOI: http://dx.doi.org/10.2307/4134564
Título revista:Biological Bulletin
Título revista abreviado:Biol. Bull.
ISSN:00063185
CODEN:BIBUB
CAS:mitogen activated protein kinase, 142243-02-5; Amyloid beta-Protein Precursor; Cyclic AMP-Dependent Protein Kinases, 2.7.1.37; Extracellular Signal-Regulated MAP Kinases, 2.7.1.37; NF-kappa B
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063185_v210_n3_p280_Romano

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Citas:

---------- APA ----------
Romano, A., Locatelli, F., Freudenthal, R., Merlo, E., Feld, M., Ariel, P., Lemos, D.,..., Fustiñana, M.S. (2006) . Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus. Biological Bulletin, 210(3), 280-288.
http://dx.doi.org/10.2307/4134564
---------- CHICAGO ----------
Romano, A., Locatelli, F., Freudenthal, R., Merlo, E., Feld, M., Ariel, P., et al. "Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus" . Biological Bulletin 210, no. 3 (2006) : 280-288.
http://dx.doi.org/10.2307/4134564
---------- MLA ----------
Romano, A., Locatelli, F., Freudenthal, R., Merlo, E., Feld, M., Ariel, P., et al. "Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus" . Biological Bulletin, vol. 210, no. 3, 2006, pp. 280-288.
http://dx.doi.org/10.2307/4134564
---------- VANCOUVER ----------
Romano, A., Locatelli, F., Freudenthal, R., Merlo, E., Feld, M., Ariel, P., et al. Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus. Biol. Bull. 2006;210(3):280-288.
http://dx.doi.org/10.2307/4134564