Artículo

Damonte, E.; Neyts, J.; Pujol, C.A.; Snoeck, R.; Andrei, G.; Ikeda, S.; Witvrouw, M.; Reymen, D.; Haines, H.; Matulewicz, M.C.; Cerezo, A.; Coto, C.E.; De Clerco, E. "Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata" (1994) Biochemical Pharmacology. 47(12):2187-2192
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Abstract:

The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption. © 1994.

Registro:

Documento: Artículo
Título:Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
Autor:Damonte, E.; Neyts, J.; Pujol, C.A.; Snoeck, R.; Andrei, G.; Ikeda, S.; Witvrouw, M.; Reymen, D.; Haines, H.; Matulewicz, M.C.; Cerezo, A.; Coto, C.E.; De Clerco, E.
Filiación:Laboratorio de Virologia, Departamento de Quimica Biologica, Argentina
Departamento de Quimica Organica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
Palabras clave:antiviral; HCMV; HIV; HSV; influenza virus; sulphated polymers; antivirus agent; plant extract; polysaccharide sulfate; virus dna; virus rna; animal cell; antiviral activity; article; concentration response; cytomegalovirus; drug cytotoxicity; drug isolation; herpes simplex virus 1; human; human cell; human immunodeficiency virus 1; human immunodeficiency virus 2; human immunodeficiency virus infection; influenza virus a; influenza virus b; junin virus; nonhuman; priority journal; respiratory syncytial pneumovirus; seaweed; simian immunodeficiency virus; virus adsorption; virus inhibition; virus replication; Antiviral Agents; Chemical Fractionation; Herpesvirus 1, Human; Microbial Sensitivity Tests; Polysaccharides; Seaweed; Support, Non-U.S. Gov't; Virus Replication
Año:1994
Volumen:47
Número:12
Página de inicio:2187
Página de fin:2192
DOI: http://dx.doi.org/10.1016/0006-2952(94)90254-2
Título revista:Biochemical Pharmacology
Título revista abreviado:Biochem. Pharmacol.
ISSN:00062952
CODEN:BCPCA
CAS:Antiviral Agents; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v47_n12_p2187_Damonte

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Citas:

---------- APA ----------
Damonte, E., Neyts, J., Pujol, C.A., Snoeck, R., Andrei, G., Ikeda, S., Witvrouw, M.,..., De Clerco, E. (1994) . Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata. Biochemical Pharmacology, 47(12), 2187-2192.
http://dx.doi.org/10.1016/0006-2952(94)90254-2
---------- CHICAGO ----------
Damonte, E., Neyts, J., Pujol, C.A., Snoeck, R., Andrei, G., Ikeda, S., et al. "Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata" . Biochemical Pharmacology 47, no. 12 (1994) : 2187-2192.
http://dx.doi.org/10.1016/0006-2952(94)90254-2
---------- MLA ----------
Damonte, E., Neyts, J., Pujol, C.A., Snoeck, R., Andrei, G., Ikeda, S., et al. "Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata" . Biochemical Pharmacology, vol. 47, no. 12, 1994, pp. 2187-2192.
http://dx.doi.org/10.1016/0006-2952(94)90254-2
---------- VANCOUVER ----------
Damonte, E., Neyts, J., Pujol, C.A., Snoeck, R., Andrei, G., Ikeda, S., et al. Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata. Biochem. Pharmacol. 1994;47(12):2187-2192.
http://dx.doi.org/10.1016/0006-2952(94)90254-2