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Kleiman De Pisarev, D.L.; Del Carmen Rios De Molina, M.; San Martin De Viale, L.C. "Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria" (1990) Biochemical Pharmacology. 39(5):817-825
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Abstract:

The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined. Female Wistar rats were treated with HCB for 1 or 8 weeks. At both treatment times liver weight was notably increased with a slight change in thyroid weight at 8 weeks. Serum thyroxine (T4) levels were depressed, whereas levels of triiodothyronine (T3) were not depressed significantly at both treatment times. One or eight weeks of HCB treatment did not alter the incorporation and distribution of [125I] into intrathyroidal aminoacids. A 50% reduction in protein bound iodine (PB[125I]) was seen in both groups of animals. HCB altered [125I]T4 metabolism in rat liver slices, increasing T4 dehalogenation. HCB administration for 1 week did not affect urinary excretion of porphyrins or their precursors, or hepatic porphyrin content. The activity of aminolaevulinate synthase was not affected, but there was a 25% and 51% inhibition in porphyrinogen carboxy-lyase (PCL) activity for the uroporphyrinogen disappearance or the coproporphyrinogen formation respectively. After 8 weeks of HCB administration the rats showed a characteristic porphyria. Our results show that HCB treatment increased hepatic thyroxine metabolism, without alterations in thyroid hormone synthesis. Serum T4 and PCL activity behaved differently in both time- and dose-dependent studies, with serum T4 being the more sensitive parameter which responded at earlier times and lower doses. © 1990.

Registro:

Documento: Artículo
Título:Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
Autor:Kleiman De Pisarev, D.L.; Del Carmen Rios De Molina, M.; San Martin De Viale, L.C.
Filiación:Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departmento de Ouímica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Núnez, Buenos Aires 1428, Argentina
Palabras clave:5 aminolevulinate synthase; hexachlorobenzene; propylthiouracil; radioisotope; thyroxine; animal experiment; article; female; liothyronine blood level; liver weight; nonhuman; porphyria; priority journal; protein bound iodine; rat; thyroid function; thyrotropin blood level; thyroxine blood level; thyroxine metabolism; 5-Aminolevulinate Synthetase; Animal; Body Weight; Chlorobenzenes; Dose-Response Relationship, Drug; Female; Hexachlorobenzene; Iodine Radioisotopes; Liver; Organ Weight; Porphyria; Porphyrins; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Thyroid Gland; Thyroxine; Triiodothyronine
Año:1990
Volumen:39
Número:5
Página de inicio:817
Página de fin:825
DOI: http://dx.doi.org/10.1016/0006-2952(90)90195-Q
Título revista:Biochemical Pharmacology
Título revista abreviado:Biochem. Pharmacol.
ISSN:00062952
CODEN:BCPCA
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Chlorobenzenes; Hexachlorobenzene, 118-74-1; Iodine Radioisotopes; Porphyrins; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v39_n5_p817_KleimanDePisarev

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Citas:

---------- APA ----------
Kleiman De Pisarev, D.L., Del Carmen Rios De Molina, M. & San Martin De Viale, L.C. (1990) . Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. Biochemical Pharmacology, 39(5), 817-825.
http://dx.doi.org/10.1016/0006-2952(90)90195-Q
---------- CHICAGO ----------
Kleiman De Pisarev, D.L., Del Carmen Rios De Molina, M., San Martin De Viale, L.C. "Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria" . Biochemical Pharmacology 39, no. 5 (1990) : 817-825.
http://dx.doi.org/10.1016/0006-2952(90)90195-Q
---------- MLA ----------
Kleiman De Pisarev, D.L., Del Carmen Rios De Molina, M., San Martin De Viale, L.C. "Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria" . Biochemical Pharmacology, vol. 39, no. 5, 1990, pp. 817-825.
http://dx.doi.org/10.1016/0006-2952(90)90195-Q
---------- VANCOUVER ----------
Kleiman De Pisarev, D.L., Del Carmen Rios De Molina, M., San Martin De Viale, L.C. Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. Biochem. Pharmacol. 1990;39(5):817-825.
http://dx.doi.org/10.1016/0006-2952(90)90195-Q