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Abstract:

Reciprocal interaction between β-adrenoceptor specific ligand occupancy and alloantibody binding to specific antigens of cardiac and smooth muscle tissues was observed. Interference of alloimmune antibody fixation to both cardiac and oviductal tract preparations by β1 or β2 selective blockers, respectively, was obtained by means of indirect immunofluorescence assays. Reciprocally, alloimmune IgG and monoclonal antibodies directed to class I H-2 antigens, behaving as β-adrenoceptor agonists, modified the contractility of both tissues, increasing intracellular levels of cyclic AMP (cAMP). Additionally, alloantibodies were also capable of inhibiting specific β-adrenoceptor radioligand binding to purified cardiac and smooth muscle membranes. These data suggested a modulation of β-adrenoceptor function by antibodies directed against H-2 class I histocompatibility molecules, probably through molecular interactions between both structures. © 1990.

Registro:

Documento: Artículo
Título:Major histocompatibility complex modulation of β-adrenoceptor function
Autor:Cremaschi, G.; Borda, E.; Sales, M.; Genaro, A.; Sterin-Borda, L.
Filiación:Centro de Estudios Farmacológicos y de Principlos Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), 1414 Buenos Aires, Argentina
Palabras clave:4 hydroxyoxprenolol; beta adrenergic receptor; butoxamine; cyclic amp; dihydroalprenolol; immunoglobulin g; monoclonal antibody; practolol; propranolol; unclassified drug; alloimmunization; animal cell; animal experiment; article; heart muscle; immunofluorescence; ligand binding; major histocompatibility complex; nonhuman; priority journal; smooth muscle; uterine tube; Animal; Antibodies, Monoclonal; Butoxamine; Cyclic AMP; Female; Heart; Immunoglobulin Allotypes; Immunoglobulin G; Ligands; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Muscle, Smooth; Myocardium; Practolol; Propranolol; Receptors, Adrenergic, beta; Tritium
Año:1990
Volumen:39
Número:12
Página de inicio:1861
Página de fin:1868
DOI: http://dx.doi.org/10.1016/0006-2952(90)90602-H
Título revista:Biochemical Pharmacology
Título revista abreviado:Biochem. Pharmacol.
ISSN:00062952
CODEN:BCPCA
CAS:Antibodies, Monoclonal; Butoxamine, 2922-20-5; Cyclic AMP, 60-92-4; Immunoglobulin Allotypes; Immunoglobulin G; Ligands; Practolol, 6673-35-4; Propranolol, 525-66-6; Receptors, Adrenergic, beta; Tritium, 10028-17-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v39_n12_p1861_Cremaschi

Referencias:

  • Lafuse, Edidin, Influence of the major histocompatibility complex, H-2, on liver adenylate cyclase activity and on glucagon binding to liver cell membranes (1980) Biochemistry, 19, pp. 49-54
  • Edidin, MHC antigens and non-immune functions (1983) Immunol Today, 4, pp. 269-270
  • Fehlmann, Peyron, Samsom, Van Obberghen, Brandeburg, Brossette, Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes (1985) Proc Natl Acad Sci USA, 82, pp. 8634-8637. , 3rd Edn
  • Phillips, Moule, Delovitch, Vip, Class I histocompatibility antigens and insulin receptors: Evidence for interactions (1986) Proc Natl Acad Sci USA, 83, pp. 3474-3478. , 3rd Edn
  • Cousin, Samson, Pilch, Fehlmann, Internalization of insulin receptors and HLA antigens in human hepatoma cells (1987) Biochem J, 242, pp. 403-410
  • Schreiber, Schlessinger, Edidin, Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells (1984) J Cell Biol, 98, pp. 725-731
  • Solano, Cremaschi, Sánchez, Borda, Sterin-Borda, Podesta, Molecular and biological interaction between major histocompatibility complex class I antigens and luteinizing hormone receptors or β-adrenergic receptors triggers cellular response in mice (1988) Proc NatlAcad Sci USA, 85, pp. 5087-5091. , 3rd Edn
  • Cremaschi, Genaro, Sales, Sterin-Borda, Positive inotropic and chronotropic effect of alloimmune sera on isolated mouse atria (1983) Experientia, 39, pp. 1026-1028
  • Cremaschi, Sterin-Borda, Genaro, Borda, Braun, Pharmacologie effects on mouse isolated atria of immunoglobulins directed against class I histocompatibility antigens (1984) J Immunol, 133, pp. 2681-2685
  • Sterin-Borda, Gimeno, Gimeno, Frequencyforce relationship on isolated rat and guinea pig atria Effects of cholinergic and adrenergic receptor antagonists (1974) Experimental Biology and Medicine, 145, pp. 1151-1157. , 3rd Edn
  • Borda, Sterin-Borda, Gimeno, Speziale, Gimeno, Molility of the rat oviductal tract isolated in different stages of the sex cycle (1975) Int J Fertil, 20, pp. 170-175
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J Biol Chem, 193, pp. 265-275
  • Pascual, Borda, Cossio, Arana, Sterin-Borda, Modification of sarcolemmal enzymes by chagasic IgG and its effect on cardiac contractility (1986) Biochem Pharmacol, 35, pp. 3839-3845
  • Johnson, Holborow, Dorling, Immunofluorescence and immunoenzyme technique (1978) Experimental Immunology, , 3rd Edn, Blackwell Scientific Publications, Oxford, Chap. 8
  • Sagripanti, Santa Coloma, Calvo, A simple computer program for Scatchard plot analysis of hormone receptors including statistical analysis on a low cost desk top calculator (1984) Acta Physiol Pharmacol Latinoam, 34, pp. 45-53
  • Lands, Arnold, McAuliff, Ludueña, Brown, Jr, Differentiation of receptor system activated by sympathomimetic amines (1967) Nature, 214, pp. 597-598
  • Minneman, Hedberg, Molinoff, Comparison of beta adrenergic receptor subtypes in mammalian tissues (1979) J Pharmacol Exp Ther, 211, pp. 502-508
  • Cremaschi, Genaro, Sterin-Borda, Colchicine blocks adrenoceptor and class I antigen specific interactions (1989) Mol Immunol, 26, pp. 601-609
  • Milton, Fabre, Massive induction of donortype class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat (1985) J Exp Med, 161, pp. 98-112
  • Flavell, Weiss, Mellor, The generation of polymorphism in H-2 genes (1983) Progress in Immunology, pp. 215-221. , Academic Press, New York
  • Kobilka, Dixon, Frielle, Dohlman, Bolanowski, Sigal, Yang-Feng, Lefkowitz, cDNA for the human beta2 adrenergic receptor: A protein with multiple membrane spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor (1987) Proc Natl Acad Sci USA, 84, pp. 46-51. , 2nd Edn
  • Due, Simonsen, Olsson, The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: Implications for the range of biological functions of histocompatibility antigens (1986) Proc Natl Acad Sci USA, 83, pp. 6007-6011. , 2nd Edn
  • Smeraldi, Scorza-Smeraldi, Interference between anti-HLA antibodies and chlorpromazine (1976) Nature, 260, pp. 532-533
  • Simonsen, Olsson, Possible roles of compound membrane receptors in the immune system (1983) Ann Immunol, 134, pp. 85-92
  • Hackman, Schiltze, Henis, Elson, Helmreich, Mobility, localization and heterogeneity of beta adrenergic receptors (1984) Adv Cyclic Nucleotide Protein Phosphorylation Res, 17, pp. 47-60

Citas:

---------- APA ----------
Cremaschi, G., Borda, E., Sales, M., Genaro, A. & Sterin-Borda, L. (1990) . Major histocompatibility complex modulation of β-adrenoceptor function. Biochemical Pharmacology, 39(12), 1861-1868.
http://dx.doi.org/10.1016/0006-2952(90)90602-H
---------- CHICAGO ----------
Cremaschi, G., Borda, E., Sales, M., Genaro, A., Sterin-Borda, L. "Major histocompatibility complex modulation of β-adrenoceptor function" . Biochemical Pharmacology 39, no. 12 (1990) : 1861-1868.
http://dx.doi.org/10.1016/0006-2952(90)90602-H
---------- MLA ----------
Cremaschi, G., Borda, E., Sales, M., Genaro, A., Sterin-Borda, L. "Major histocompatibility complex modulation of β-adrenoceptor function" . Biochemical Pharmacology, vol. 39, no. 12, 1990, pp. 1861-1868.
http://dx.doi.org/10.1016/0006-2952(90)90602-H
---------- VANCOUVER ----------
Cremaschi, G., Borda, E., Sales, M., Genaro, A., Sterin-Borda, L. Major histocompatibility complex modulation of β-adrenoceptor function. Biochem. Pharmacol. 1990;39(12):1861-1868.
http://dx.doi.org/10.1016/0006-2952(90)90602-H