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Abstract:

It has been shown that sera from chagasic patients contain an antibody which binds to β-adrenoceptors of myocardium and modulates their activity. Chagasic IgG triggered a marked stimulation of myocardial contractility with an increase in intramyocardial cyclic AMP and inhibition of (Na+ + K+)-ATPase activity. both the mechanical and enzymatic effects of the IgG could be prevented by β-adrenoceptor blockade or after the absorption of chagasic IgG with turkey red blood cells. In contrast, guinea pig red blood cells were unable to remove the β-reactivity of chagasic IgG. These findings suggest that the IgG from chagasic patients increases myocardial contractility by behaving as a β-agonist. This effect is likely related to stimulation of the adenylate cyclase coupled to the cardiac β-adrenoceptor. © 1986.

Registro:

Documento: Artículo
Título:Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility
Autor:Pascual, J.; Borda, E.; Cossio, P.; Arana, R.; Sterin-Borda, L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665/69, 1414 Buenos Aires, Argentina
Centro Médico de Educación Médica, Investigación Clínica (CEMIC), Serrano 665/69, 1414 Buenos Aires, Argentina
Palabras clave:adenosine triphosphatase (potassium sodium); beta adrenergic receptor; chagas disease antibody; cyclic AMP; immunoglobulin G; isoprenaline; ouabain; propranolol; theophylline; unclassified drug; article; bird; blood and hemopoietic system; Chagas disease; dose response; drug antagonism; drug mechanism; drug response; enzyme modification; erythrocyte; etiology; guinea pig; heart; heart contraction; human; muscle; muscle contractility; priority journal; rat; turkey (bird); Adenylate Cyclase; Animals; Chagas Cardiomyopathy; Chagas Disease; Cyclic AMP; Guinea Pigs; Humans; Immunoglobulin G; Male; Myocardial Contraction; Myocardium; Na(+)-K(+)-Exchanging ATPase; Rats; Sarcolemma; Turkeys
Año:1986
Volumen:35
Número:21
Página de inicio:3839
Página de fin:3845
DOI: http://dx.doi.org/10.1016/0006-2952(86)90673-8
Título revista:Biochemical Pharmacology
Título revista abreviado:Biochem. Pharmacol.
ISSN:00062952
CODEN:BCPCA
CAS:cyclic AMP, 60-92-4; immunoglobulin G, 97794-27-9; isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2; ouabain, 11018-89-6, 630-60-4; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; theophylline, 58-55-9, 5967-84-0, 8055-07-0, 8061-56-1, 99007-19-9; Adenylate Cyclase, 4.6.1.1; Cyclic AMP, 60-92-4; Immunoglobulin G; Na(+)-K(+)-Exchanging ATPase, 3.6.1.37
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v35_n21_p3839_Pascual

Referencias:

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Citas:

---------- APA ----------
Pascual, J., Borda, E., Cossio, P., Arana, R. & Sterin-Borda, L. (1986) . Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility. Biochemical Pharmacology, 35(21), 3839-3845.
http://dx.doi.org/10.1016/0006-2952(86)90673-8
---------- CHICAGO ----------
Pascual, J., Borda, E., Cossio, P., Arana, R., Sterin-Borda, L. "Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility" . Biochemical Pharmacology 35, no. 21 (1986) : 3839-3845.
http://dx.doi.org/10.1016/0006-2952(86)90673-8
---------- MLA ----------
Pascual, J., Borda, E., Cossio, P., Arana, R., Sterin-Borda, L. "Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility" . Biochemical Pharmacology, vol. 35, no. 21, 1986, pp. 3839-3845.
http://dx.doi.org/10.1016/0006-2952(86)90673-8
---------- VANCOUVER ----------
Pascual, J., Borda, E., Cossio, P., Arana, R., Sterin-Borda, L. Modification of sarcolemmal enzymes by chagasic IgG and its effect of cardiac contractility. Biochem. Pharmacol. 1986;35(21):3839-3845.
http://dx.doi.org/10.1016/0006-2952(86)90673-8