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Abstract:

The present work deals with the effect of desferrioxamine (DP) on hexachlorobenzene (HCB)-induced porphyria in female rats with the purpose of further investigation of the role of iron in the development of this porphyria. The results obtained show that the repeated injection of DF (three times a week: 100 mg/kg each i.m.) delayed and diminished remarkably the urinary excretion of precursors and porphyrins as well as the accumulation of the latter in liver promoted by HCB (1 g/kg daily given by stomach tube). This was probably due to attenuation by DF of the alterations produced by the fungicide in the two key enzymes: porphyrinogen carboxy-lyase (PCL) and δ-aminolaevulinate synthase (ALA-S). In fact, DF by reducing liver iron levels produced a smaller decrease of the target enzyme (PCL) and a concomitant smaller induction of ALA-S. DF alone did not modify any of these variables or the liver to body weight ratio. DF added at 10-2 and 10-3 M to the incubation media of ALA-S and PCL did not alter either of the enzymatic activities, whether in normal or HCB-porphyric preparations. The results obtained show that DF improved the biochemical picture during HCB porphyria. They suggest that iron plays an indirect role in the decrease of PCL enzyme, possibly at the HCB metabolization step. A common iron-involving mechanism for the production of porphyria by different chlorinated compounds is suggested. © 1986.

Registro:

Documento: Artículo
Título:Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria
Autor:de Calmanovici, R.W.; Billi, S.C.; Sldonatti, C.A.; De Viale, l.C.S.M.
Filiación:Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nunez, 1428, Buenos Aires, Argentina, Argentina
Palabras clave:deferoxamine; hexachlorobenzene; iron; porphyrin; animal cell; animal experiment; drug comparison; drug dose; drug efficacy; intramuscular drug administration; liver; methodology; nonhuman; priority journal; rat; topical drug administration; urinary tract; 5-Aminolevulinate Synthetase; Animal; Body Weight; Carboxy-Lyases; Chlorobenzenes; Deferoxamine; Disease Models, Animal; Female; Hexachlorobenzene; Iron; Liver; Organ Weight; Porphyria; Porphyrins; Rats; Skin Diseases; Support, Non-U.S. Gov't
Año:1986
Volumen:35
Número:14
Página de inicio:2399
Página de fin:2405
DOI: http://dx.doi.org/10.1016/0006-2952(86)90467-3
Título revista:Biochemical Pharmacology
Título revista abreviado:Biochem. Pharmacol.
ISSN:00062952
CODEN:BCPCA
CAS:deferoxamine, 70-51-9; hexachlorobenzene, 118-74-1, 55600-34-5; iron, 14093-02-8, 53858-86-9, 7439-89-6; porphyrin, 24869-67-8; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Carboxy-Lyases, EC 4.1.1.; Chlorobenzenes; Deferoxamine, 70-51-9; Hexachlorobenzene, 118-74-1; Iron, 7439-89-6; porphyrinogen carboxy-lyase, EC 4.1.1.-; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v35_n14_p2399_deCalmanovici

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Citas:

---------- APA ----------
de Calmanovici, R.W., Billi, S.C., Sldonatti, C.A. & De Viale, l.C.S.M. (1986) . Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria. Biochemical Pharmacology, 35(14), 2399-2405.
http://dx.doi.org/10.1016/0006-2952(86)90467-3
---------- CHICAGO ----------
de Calmanovici, R.W., Billi, S.C., Sldonatti, C.A., De Viale, l.C.S.M. "Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria" . Biochemical Pharmacology 35, no. 14 (1986) : 2399-2405.
http://dx.doi.org/10.1016/0006-2952(86)90467-3
---------- MLA ----------
de Calmanovici, R.W., Billi, S.C., Sldonatti, C.A., De Viale, l.C.S.M. "Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria" . Biochemical Pharmacology, vol. 35, no. 14, 1986, pp. 2399-2405.
http://dx.doi.org/10.1016/0006-2952(86)90467-3
---------- VANCOUVER ----------
de Calmanovici, R.W., Billi, S.C., Sldonatti, C.A., De Viale, l.C.S.M. Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria. Biochem. Pharmacol. 1986;35(14):2399-2405.
http://dx.doi.org/10.1016/0006-2952(86)90467-3