Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptophan pyrrolase activity is diminished in porphyric animals. This is interpreted as being the result, at least in part, of a competitive inhibition between the porphyrins accumulated in the liver during the state of porphyria and the tryptophan pyrrolase heme coenzyme, for the tryptophan pyrrolase apoenzyme. © 1967.
| Documento: | Artículo |
| Título: | Tryptophan metabolism in experimental porphyria |
| Autor: | Garcia, A.F.; Grinstein, M. |
| Filiación: | Catedra de Quimica Biologica I, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina |
| Palabras clave: | kynurenine; tryptophan; tryptophan 2,3 dioxygenase; animal; article; chromatography; enzymology; liver; male; metabolism; porphyria; rat; urine; Animal; Chromatography; Kynurenine; Liver; Male; Porphyria; Rats; Tryptophan; Tryptophan Oxygenase |
| Año: | 1967 |
| Volumen: | 16 |
| Número: | 10 |
| Página de inicio: | 1967 |
| Página de fin: | 1969 |
| DOI: | http://dx.doi.org/10.1016/0006-2952(67)90307-3 |
| Título revista: | Biochemical Pharmacology |
| Título revista abreviado: | Biochem. Pharmacol. |
| ISSN: | 00062952 |
| CODEN: | BCPCA |
| CAS: | kynurenine, 16055-80-4, 343-65-7; tryptophan 2,3 dioxygenase, 9014-51-1; tryptophan, 6912-86-3, 73-22-3; Kynurenine, 343-65-7; Tryptophan Oxygenase, EC 1.13.11.11; Tryptophan, 73-22-3 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v16_n10_p1967_Garcia |
