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During the last years, progress has been made on the identification of mechanisms involved in anterior pituitary cell transformation and tumorigenesis. Oncogene activation, tumor suppressor gene inactivation, epigenetic changes, and microRNAs deregulation contribute to the initiation of pituitary tumors. Despite the high prevalence of pituitary adenomas, they are mostly benign, indicating that intrinsic mechanisms may regulate pituitary cell expansion. Senescence is characterized by an irreversible cell cycle arrest and represents an important protective mechanism against malignancy. Pituitary tumor transforming gene (PTTG) is an oncogene involved in early stages of pituitary tumor development, and also triggers a senescence response by activating DNA-damage signaling pathway. Cytokines, as well as many other factors, play an important role in pituitary physiology, affecting not only cell proliferation but also hormone secretion. Special interest is focused on interleukin-6 (IL-6) because its dual function of stimulating pituitary tumor cell growth but inhibiting normal pituitary cells proliferation. It has been demonstrated that IL-6 has a key role in promoting and maintenance of the senescence program in tumors. Senescence, triggered by PTTG activation and mediated by IL-6, may be a mechanism for explaining the benign nature of pituitary tumors. © 2015, Springer Science+Business Media New York.


Documento: Artículo
Título:Molecular Mechanisms Underlying Pituitary Pathogenesis
Autor:Sapochnik, M.; Nieto, L.E.; Fuertes, M.; Arzt, E.
Filiación:Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, C1425FQD, Argentina
Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428EGA, Argentina
Palabras clave:IL-6; OIS; Pituitary tumors; PTTG; Senescence; interleukin 6; microRNA; IL6 protein, human; interleukin 6; microRNA; pituitary tumor-transforming protein 1, human; securin; carcinogenesis; cell cycle; cell proliferation; human; hypophysis adenoma; hypophysis tumor; oncogene; Review; senescence; signal transduction; adenoma; cell aging; DNA damage; genetic epigenesis; genetics; hypophysis; hypophysis tumor; metabolism; pathology; tumor suppressor gene; Adenoma; Cell Aging; Cell Cycle; DNA Damage; Epigenesis, Genetic; Genes, Tumor Suppressor; Humans; Interleukin-6; MicroRNAs; Oncogenes; Pituitary Gland; Pituitary Neoplasms; Securin; Signal Transduction
Página de inicio:107
Página de fin:119
Título revista:Biochemical Genetics
Título revista abreviado:Biochem. Genet.
CAS:IL6 protein, human; Interleukin-6; MicroRNAs; pituitary tumor-transforming protein 1, human; Securin


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---------- APA ----------
Sapochnik, M., Nieto, L.E., Fuertes, M. & Arzt, E. (2016) . Molecular Mechanisms Underlying Pituitary Pathogenesis. Biochemical Genetics, 54(2), 107-119.
---------- CHICAGO ----------
Sapochnik, M., Nieto, L.E., Fuertes, M., Arzt, E. "Molecular Mechanisms Underlying Pituitary Pathogenesis" . Biochemical Genetics 54, no. 2 (2016) : 107-119.
---------- MLA ----------
Sapochnik, M., Nieto, L.E., Fuertes, M., Arzt, E. "Molecular Mechanisms Underlying Pituitary Pathogenesis" . Biochemical Genetics, vol. 54, no. 2, 2016, pp. 107-119.
---------- VANCOUVER ----------
Sapochnik, M., Nieto, L.E., Fuertes, M., Arzt, E. Molecular Mechanisms Underlying Pituitary Pathogenesis. Biochem. Genet. 2016;54(2):107-119.