Abstract:
Inhibition of E. coli growth by cyclic adenosine monophosphate is observed in wild type strains cultured in glucose as carbon source, but not in a cyclic AMP receptor protein deficient mutant. A deletion mutant of the adenylate cyclase gene requires cyclic adenosine monophosphate for optimal growth. Using glucose as carbon source, 2 mM cyclic AMP promotes maximal rates of cell multiplication in this mutant; however higher concentrations of the nucleotide inhibit growth. Cell multiplication of wild type strains grown in glycerol is not affected by cyclic adenosine monophosphate. Nevertheless, in this carbon source the growth rate of the adenylate cyclase mutant is strongly inhibited by concentrations of this nucleotide beyond 0.1 mM. This suggests that growth inhibition by exogenous cyclic adenosine monophosphate is highly dependent on the intracellular levels of the nucleotide. © 1973.
Registro:
Documento: |
Artículo
|
Título: | On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate |
Autor: | De Robertis Jr., E.M.; Judewicz, N.D.; Torres, H.N. |
Filiación: | Instituto de Investigaciones Bioquímicas Fundación Campomar, Facultad de Ciencias Exactas y Naturales Obligado, 2490 Buenos Aires (28), Argentina
|
Palabras clave: | adenylate cyclase; cyclic amp; bacterium; cell division; cell growth; escherichia coli; growth; in vitro study; microorganism; theoretical study; Adenylate Cyclase; Cell Division; Culture Media; Cyclic AMP; Enzyme Induction; Escherichia coli; Galactose; Galactosidases; Glucose; Glycerol; Glycosides; Mutation; Nitrosoguanidines; Receptors, Drug; Spectrophotometry; Sulfhydryl Compounds; Thiamine; Time Factors |
Año: | 1973
|
Volumen: | 55
|
Número: | 3
|
Página de inicio: | 758
|
Página de fin: | 764
|
DOI: |
http://dx.doi.org/10.1016/0006-291X(73)91209-6 |
Título revista: | Biochemical and Biophysical Research Communications
|
Título revista abreviado: | Biochem. Biophys. Res. Commun.
|
ISSN: | 0006291X
|
CODEN: | BBRCA
|
CAS: | adenylate cyclase, 9012-42-4; cyclic AMP, 60-92-4; Adenylate Cyclase, EC 4.6.1.1; Culture Media; Cyclic AMP, 60-92-4; Galactose, 26566-61-0; Galactosidases, EC 3.2.1.-; Glucose, 50-99-7; Glycerol, 56-81-5; Glycosides; Nitrosoguanidines; Receptors, Drug; Sulfhydryl Compounds; Thiamine, 59-43-8
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v55_n3_p758_DeRobertisJr |
Referencias:
- Judewicz, De Robertis, Jr., Torres, (1973) Biochem. Biophys. Res. Commun, 52, pp. 1257-1262
- Perlman, de Crombrugghe, Pastan, (1969) Nature, 223, pp. 810-812
- Perlman, Pastan, (1968) Biochim. Biophys. Res. Commun, 30, pp. 656-664
- Mc Fall, Mandelstam, (1963) Biochem. J, 89, pp. 391-398
- Pastan, Perlman, (1970) Science, 169, pp. 339-344
- Makman, Sutherland, (1965) J. Biol. Chem, 240, pp. 1309-1314
- Peterkofsky, Gazdar, (1971) Proc. Natl. Acad. Sci. U.S.A, 68, pp. 2794-2798. , 2nd ed
- Buettner, Spitz, Rickenberg, (1973) J. Bacteriol, 114, pp. 1068-1073
- Johnson, Friedman, Pastan, (1971) Proc. Natl. Acad. Sci. U.S.A, 68, pp. 425-429. , 2nd ed
- Sneppard, Restoration of Contact-Inhibited Growth to Transformed Cells by Dibutyryl Adenosine 3':5'-Cyclic Monophosphate (1971) Proceedings of the National Academy of Sciences, 68, pp. 1316-1320. , 2nd ed
- Jiménez de Asua, Surian, Flawiá, Torres, Effect of Insulin on the Growth Pattern and Adenylate Cyclase Activity of BHK Fibroblasts (1973) Proceedings of the National Academy of Sciences, 70, pp. 1388-1392. , 2nd ed
- Emmer, de Crombrugghe, Pastan, Perlman, (1970) Proc. Acad. Sci. U.S.A, 66, pp. 480-487. , 2nd ed
- Riggs, Reiness, Zubay, (1971) Proc. Natl. Acad. Sci. U.S.A, 68, pp. 1222-1225. , 2nd ed
- Schwartz, Beckwith, (1970) The lac Operon, pp. 417-422. , D. Zipser, J. Beckwith, Cold Spring Harbor Laboratory of Quantitative Biology, N.Y
- Nissley, Anderson, Gallo, Pastan, Perlman, (1972) J. Biol. Chem, 247, pp. 4264-4269
- Perlman, Pastan, (1969) Biochem. Biophys. Res. Commun, 37, pp. 151-154
- Jost, Rickenberg, Cyclic Amp (1971) Annual Review of Biochemistry, 40, p. 741
- Beckwith, J., Personal communication; Gilman, (1970) Proc. Natl. Acad. Sci. U.S.A, 67, pp. 305-312. , 2nd ed
- Ullmann, Monod, (1968) FEBS Letters, 2, pp. 57-60
- Wise, Jr., Alexander, Powers, (1973) Proc. Natl. Acad. Sci. U.S.A, 70, p. 471. , 2nd ed
- Ackerman, R.S., Cozzarelli, N. R. and Epstein, W., J. Bacteriol., in press; Kram, Mamont, Tomkins, (1973) Proc. Natl. Acad. Sci. U.S.A, 70, pp. 1432-1436. , 2nd ed
- Hauschka, Everhart, Rubin, (1972) Proc. Natl. Acad. Sci. U.S.A, 69, pp. 3542-3546. , 2nd ed
- Grimes, Schroeder, (1973) J. Cell Biol, 56, pp. 487-491
Citas:
---------- APA ----------
De Robertis Jr., E.M., Judewicz, N.D. & Torres, H.N.
(1973)
. On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate. Biochemical and Biophysical Research Communications, 55(3), 758-764.
http://dx.doi.org/10.1016/0006-291X(73)91209-6---------- CHICAGO ----------
De Robertis Jr., E.M., Judewicz, N.D., Torres, H.N.
"On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate"
. Biochemical and Biophysical Research Communications 55, no. 3
(1973) : 758-764.
http://dx.doi.org/10.1016/0006-291X(73)91209-6---------- MLA ----------
De Robertis Jr., E.M., Judewicz, N.D., Torres, H.N.
"On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate"
. Biochemical and Biophysical Research Communications, vol. 55, no. 3, 1973, pp. 758-764.
http://dx.doi.org/10.1016/0006-291X(73)91209-6---------- VANCOUVER ----------
De Robertis Jr., E.M., Judewicz, N.D., Torres, H.N. On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate. Biochem. Biophys. Res. Commun. 1973;55(3):758-764.
http://dx.doi.org/10.1016/0006-291X(73)91209-6