Artículo
Bueno, C.A.; Alché, L.E.; Barquero, A.A. "1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity" (2010) Biochemical and Biophysical Research Communications. 393(1):32-37
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Abstract:
The 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), isolated from extracts of Melia azedarach L., displays antiviral and immunomodulating properties. CDM is the first reported tetranortriterpenoid responsible for the alkalinization of intracellular compartments affecting both, viral endocytic and exocytic pathways. Considering that viral glycoprotein synthesis is completely dependent upon cellular membrane trafficking, we questioned whether CDM might also interfere with the normal transport of cellular glycoproteins. This study demonstrates that CDM promoted a transient block in the transport of two cellular glycoproteins, the transferrin receptor (TfR) and TNF-α. Nevertheless, CDM did not affect the transferrin binding ability of TfR and did not impede the TNF-α secretion. On the other hand, CDM disturbed the intracellular localization of capsid, glycoprotein and tegument proteins simultaneously in the same HSV-1 infected cells. Besides, we show that concanamycin A and monensin provoke a permanent blockage of viral and cellular glycoproteins, in contrast to the delay observed after CDM treatment. Thus, the delay on glycoprotein transport caused by CDM would account for the strong inhibition on virus multiplication without interfering with the bioactivity of cellular glycoproteins. © 2010 Elsevier Inc. All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | 1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity |
| Autor: | Bueno, C.A.; Alché, L.E.; Barquero, A.A. |
| Filiación: | Laboratorio de Virología, Departamento de Química Biológica, FCEN, Pabellon II- Piso 4to, Ciudad Universitaria, C, 1428BGA Buenos Aires, Argentina |
| Palabras clave: | Antiviral; Golgi apparatus; Medicinal plants; Secretory pathway; Transferrin receptor; 1 cinnamoyl 3,11 dihydroxymeliacarpin; concanamycin A; glycoprotein; Melia azedarach extract; monensin; transferrin receptor; triterpenoid; unclassified drug; alkalinization; article; cell compartmentalization; cell membrane; controlled study; cytotoxicity; drug activity; drug inhibition; endosome; glycoprotein synthesis; Herpes simplex virus 1; human; human cell; immunomodulation; integument; Melia azedarach; membrane transport; nonhuman; priority journal; protein binding; protein localization; protein transport; virogenesis; virus capsid; Antiviral Agents; Cell Line; Glycoproteins; Herpesvirus 1, Human; Humans; Limonins; Macrolides; Melia azedarach; Monensin; Protein Transport; Receptors, Transferrin; Tumor Necrosis Factor-alpha; Viral Envelope Proteins; Virus Replication; Human herpesvirus 1; Melia azedarach; Miridae |
| Año: | 2010 |
| Volumen: | 393 |
| Número: | 1 |
| Página de inicio: | 32 |
| Página de fin: | 37 |
| DOI: | http://dx.doi.org/10.1016/j.bbrc.2010.01.068 |
| Título revista: | Biochemical and Biophysical Research Communications |
| Título revista abreviado: | Biochem. Biophys. Res. Commun. |
| ISSN: | 0006291X |
| CODEN: | BBRCA |
| CAS: | concanamycin A, 66771-59-3, 80890-47-7; monensin, 17090-79-8, 22373-78-0; 1-cinnamoyl-3,11-dihydroxymeliacarpin; Antiviral Agents; Glycoproteins; Limonins; Macrolides; Monensin, 17090-79-8; Receptors, Transferrin; Tumor Necrosis Factor-alpha; Viral Envelope Proteins; concanamycin A, 80890-47-7; glycoprotein gD, herpes simplex virus type 1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v393_n1_p32_Bueno |
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Citas:
---------- APA ----------
Bueno, C.A., Alché, L.E. & Barquero, A.A. (2010) . 1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity. Biochemical and Biophysical Research Communications, 393(1), 32-37.http://dx.doi.org/10.1016/j.bbrc.2010.01.068
---------- CHICAGO ----------
Bueno, C.A., Alché, L.E., Barquero, A.A. "1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity" . Biochemical and Biophysical Research Communications 393, no. 1 (2010) : 32-37.http://dx.doi.org/10.1016/j.bbrc.2010.01.068
---------- MLA ----------
Bueno, C.A., Alché, L.E., Barquero, A.A. "1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity" . Biochemical and Biophysical Research Communications, vol. 393, no. 1, 2010, pp. 32-37.http://dx.doi.org/10.1016/j.bbrc.2010.01.068
---------- VANCOUVER ----------
Bueno, C.A., Alché, L.E., Barquero, A.A. 1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity. Biochem. Biophys. Res. Commun. 2010;393(1):32-37.http://dx.doi.org/10.1016/j.bbrc.2010.01.068
