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Abstract:

We have reported the isolation of the tetranortriterpenoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM) from partially purified leaf extracts of Melia azedarach L. (MA) that reduced both, vesicular stomatitis virus (VSV) and Herpes simplex virus type 1 (HSV-1) multiplication. CDM blocks VSV entry and the intracellular transport of VSV-G protein, confining it to the Golgi apparatus, by pre- or post-treatment, respectively. Here, we report that HSV-1 glycoproteins were also confined to the Golgi apparatus independently of the nature of the host cell. Considering that MA could be acting as an immunomodulator preventing the development of herpetic stromal keratitis in mice, we also examined an eventual effect of CDM on NF-κB signaling pathway. CDM is able to impede NF-κB activation in HSV-1-infected conjunctival cells and leads to the accumulation of p65 NF-κB subunit in the cytoplasm of uninfected treated Vero cells. In conclusion, CDM is a pleiotropic agent that not only inhibits the multiplication of DNA and RNA viruses by the same mechanism of action but also modulates the NF-κB signaling pathway. © 2006 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-κB modulating properties
Autor:Barquero, A.A.; Michelini, F.M.; Alché, L.E.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellon II, Piso 4to., Ciudad Univ., C1428BGA Buenos Aires, Argentina
Palabras clave:1-Cinnamoyl-3,11-dihydroxymeliacarpin; Antiinflammatory; Herpes simplex virus type 1; Melia azedarach L.; Natural antiviral; NF-κB; Triterpenoids; 1 cinnamoyl 3,11 dihydroxymeliacarpin; antivirus agent; terpenoid derivative; unclassified drug; 1 cinnamoyl 3,11 dihydroxymeliacarpin; 1-cinnamoyl-3,11-dihydroxymeliacarpin; antivirus agent; immunoglobulin enhancer binding protein; limonoid; animal cell; article; controlled study; DNA replication; DNA virus; Golgi complex; Herpes simplex virus; host cell; immunomodulation; membrane transport; nonhuman; priority journal; purification; RNA replication; RNA virus; Vesicular stomatitis virus; virogenesis; animal; cell line; Cercopithecus; conjunctiva; dose response; drug effect; growth, development and aging; Herpes simplex virus 1; human; metabolism; physiology; Vero cell; virology; virus replication; Human herpesvirus 1; Melia azedarach; RNA viruses; Vesicular stomatitis virus; Animals; Antiviral Agents; Cell Line; Cercopithecus aethiops; Conjunctiva; Dose-Response Relationship, Drug; Herpesvirus 1, Human; Humans; Limonins; NF-kappa B; Vero Cells; Virus Replication
Año:2006
Volumen:344
Número:3
Página de inicio:955
Página de fin:962
DOI: http://dx.doi.org/10.1016/j.bbrc.2006.03.226
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:1-cinnamoyl-3,11-dihydroxymeliacarpin; Antiviral Agents; Limonins; NF-kappa B
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v344_n3_p955_Barquero

Referencias:

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Citas:

---------- APA ----------
Barquero, A.A., Michelini, F.M. & Alché, L.E. (2006) . 1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-κB modulating properties. Biochemical and Biophysical Research Communications, 344(3), 955-962.
http://dx.doi.org/10.1016/j.bbrc.2006.03.226
---------- CHICAGO ----------
Barquero, A.A., Michelini, F.M., Alché, L.E. "1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-κB modulating properties" . Biochemical and Biophysical Research Communications 344, no. 3 (2006) : 955-962.
http://dx.doi.org/10.1016/j.bbrc.2006.03.226
---------- MLA ----------
Barquero, A.A., Michelini, F.M., Alché, L.E. "1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-κB modulating properties" . Biochemical and Biophysical Research Communications, vol. 344, no. 3, 2006, pp. 955-962.
http://dx.doi.org/10.1016/j.bbrc.2006.03.226
---------- VANCOUVER ----------
Barquero, A.A., Michelini, F.M., Alché, L.E. 1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-κB modulating properties. Biochem. Biophys. Res. Commun. 2006;344(3):955-962.
http://dx.doi.org/10.1016/j.bbrc.2006.03.226