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Caro, F.; Bercovich, N.; Atorrasagasti, C.; Levin, M.J.; Vázquez, M.P. "Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi: Implications for their functions" (2005) Biochemical and Biophysical Research Communications. 333(3):1017-1025
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Abstract:

The small zinc finger proteins tbZFP1 and tbZFP2 have been implicated in the control of Trypanosoma brucei differentiation to the procyclic form. Here, we report that the complete ZFP family in Trypanosoma cruzi is composed by four members, ZFP1A and B, and ZFP2A and B. ZFP1B is a paralog specific gene restricted to T. cruzi, while the ZFP2A and B paralogs diverged prior to the trypanosomatid lineage separation. Moreover, we demonstrate that TcZFP1 and TcZFP2 members interact with each other and that this interaction is mediated by a WW domain in TcZFP2. Also, TcZFP2B strongly homodimerizes by a glycine rich region absent in TcZFP2A. We propose a model to discuss the relevance of these protein-protein interactions in terms of the functions of these proteins. © 2005 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi: Implications for their functions
Autor:Caro, F.; Bercovich, N.; Atorrasagasti, C.; Levin, M.J.; Vázquez, M.P.
Filiación:Laboratorio de Biología Molecular de la Enfermedad de Chagas-INGEBI-CONICET, Departamento de Fisiología Y Biología Molecular Y Celular, University of Buenos Aires, Vuelta de Obligado 2490 2P, 1428, Buenos Aires, Argentina
Palabras clave:CCCH zinc finger proteins; Chagas disease; Protein interactions; WW domains; glycine; unclassified drug; zinc finger protein; zinc finger protein 1a; zinc finger protein 1b; zinc finger protein 2a; zinc finger protein 2b; article; dimerization; genetic line; genetic variability; molecular model; nucleotide sequence; paralogy; priority journal; protein analysis; protein domain; protein family; protein function; protein protein interaction; Trypanosoma cruzi; Amino Acid Sequence; Animals; Base Sequence; Dimerization; DNA, Protozoan; Molecular Sequence Data; Protein Binding; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Trypanosoma cruzi; Zinc Fingers; Trypanosoma brucei; Trypanosoma cruzi; Trypanosomatidae
Año:2005
Volumen:333
Número:3
Página de inicio:1017
Página de fin:1025
DOI: http://dx.doi.org/10.1016/j.bbrc.2005.06.007
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:glycine, 56-40-6, 6000-43-7, 6000-44-8; DNA, Protozoan; Protozoan Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v333_n3_p1017_Caro

Referencias:

  • Vanhamme, L., Pays, E., Control of gene expression in trypanosomes (1995) Microbiol. Rev., 59, pp. 223-240
  • Clayton, C.E., Life without transcriptional control? from fly to man and back again (2002) EMBO J., 21, pp. 1881-1888
  • Hendriks, E.F., Robinson, D.R., Hinkins, M., Matthews, K.R., A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form (2001) EMBO J., 20, pp. 6700-6711
  • Tabara, H., Hill, R.J., Mello, C.C., Priess, J.R., Kohara, Y., Pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans (1999) Development, 126, pp. 1-11
  • Lai, W.S., Carballo, E., Thorn, J.M., Kennington, E.A., Blackshear, P.J., Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA (2000) J. Biol. Chem., 275, pp. 17827-17837
  • Lai, W.S., Kennington, E.A., Blackshear, P.J., Interactions of CCCH zinc finger proteins with mRNA: Non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs (2002) J. Biol. Chem., 277, pp. 9606-9613
  • Morking, P.A., Dallagiovanna, B.M., Foti, L., Garat, B., Picchi, G.F.A., Umaki, A.C.S., Probst, C.M., Fragoso, S.P., TcZFP1: A CCCH zinc finger protein of Trypanosoma cruzi that binds poly-C oligoribonucleotides in vitro (2004) Biochem. Biophys. Res. Commun., 319, pp. 169-177
  • Carballo, E., Lai, W.S., Blackshear, P.J., Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin (1998) Science, 281, pp. 1001-1005
  • Reese, K.J., Dunn, M.A., Waddle, J.A., Seydoux, G., Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains (2000) Mol. Cell, 6, pp. 445-455
  • Matthews, K.R., Sherwin, T., Gull, K., Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated (1995) J. Cell Sci., 108, pp. 2231-2239
  • Zarrinpar, A., Lim, W.A., Converging on proline: The mechanism of WW domain peptide recognition (2000) Nat. Struct. Biol., 7, pp. 611-613
  • Ben-Dov, C.P., Levin, M., Vazquez, M., Analysis of the highly efficient pre-mRNA processing region HX1 of Trypanosoma cruzi (2005) Mol. Biochem. Parasitol., 140, pp. 97-105
  • Sambrook, J., Russell, D., (2001) Molecular Cloning: A Laboratory Manual, , second ed. Cold Spring Harbor Laboratory Press Col Spring Harbor, New York
  • Kay, B.K., Williamson, M.P., Sudol, M., The importance of being proline: The interaction of proline-rich motifs in signaling proteins with their cognate domains (2000) FASEB J., 14, pp. 231-241
  • Hu, H., Columbus, J., Zhang, Y., Wu, D., Lian, L., Yang, S., Goodwin, J., Herrero, J.J., A map of WW domain family interactions (2004) Proteomics, 4, pp. 643-655
  • Oneyama, C., Agatsuma, T., Kanda, Y., Nakano, H., Sharma, S.V., Narazaki Nakano, F., Tatsuta, K., Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: Potent analogs of UCS15A (2003) Chem. Biol., 10, pp. 443-451
  • Zeng, J., Mini-Review: Computational structure-based design of inhibitors that target protein surfaces (2000) Comb. Chem. High Throughput Screen., 3, pp. 355-362
  • Schleinkofer, K., Wiedemann, U., Otte, L., Wang, T., Krause, G., Oschkinat, H., Wade, R.C., Comparative structural and energetic analysis of WW domain-peptide interactions (2004) J. Mol. Biol., 344, pp. 865-881

Citas:

---------- APA ----------
Caro, F., Bercovich, N., Atorrasagasti, C., Levin, M.J. & Vázquez, M.P. (2005) . Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi: Implications for their functions. Biochemical and Biophysical Research Communications, 333(3), 1017-1025.
http://dx.doi.org/10.1016/j.bbrc.2005.06.007
---------- CHICAGO ----------
Caro, F., Bercovich, N., Atorrasagasti, C., Levin, M.J., Vázquez, M.P. "Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi: Implications for their functions" . Biochemical and Biophysical Research Communications 333, no. 3 (2005) : 1017-1025.
http://dx.doi.org/10.1016/j.bbrc.2005.06.007
---------- MLA ----------
Caro, F., Bercovich, N., Atorrasagasti, C., Levin, M.J., Vázquez, M.P. "Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi: Implications for their functions" . Biochemical and Biophysical Research Communications, vol. 333, no. 3, 2005, pp. 1017-1025.
http://dx.doi.org/10.1016/j.bbrc.2005.06.007
---------- VANCOUVER ----------
Caro, F., Bercovich, N., Atorrasagasti, C., Levin, M.J., Vázquez, M.P. Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi: Implications for their functions. Biochem. Biophys. Res. Commun. 2005;333(3):1017-1025.
http://dx.doi.org/10.1016/j.bbrc.2005.06.007