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Abstract:

Leukaemia inhibitory factor (LIF) or Oncostatin M (OSM), both mitogens for Swiss mouse 3T3 cells, triggers initiation of DNA synthesis without the requirement for mevalonic acid. Thus, Lovastatin (LOV), an inhibitor of the hydroxy methylglutaryl CoA (HMGCoA) reductase, does not block LIF or OSM induced DNA replication and cell multiplication. In contrast, increasing concentrations of LOV from 1 to 60 μM block the mitogenic action of PGF 2α by decreasing the number of cells capable of entering S-phase and dividing. This inhibition by LOV can be reversed by addition of mevanolactone (MEV), an analogue of mevalonic acid. Thus, LIF or OSM triggers initiation of DNA replication independently of mevalonic acid synthesis and therefore without the involvement of isoprenylation of various signalling proteins. © 2003 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Leukaemia inhibitory factor or Oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication
Autor:Sauane, M.; Coso, O.A.; Giulianelli, S.; Giráldez, A.N.; Rudland, P.S.; Jimenez De Asua, L.
Filiación:Inst. Invest. Bioquimicas Fund. I., Av. Patricias Argentinas 435, (1405) Buenos Aires, Argentina
Lab. de Fisiol. y Biol. Molecular, F.C.E.N, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
Palabras clave:DNA replication; Insulin; Leukaemia inhibitory factor; Mevalonic acid; Oncostatin M; 3 hydroxy 3 methylglutaryl coenzyme A; DNA; leukemia inhibitory factor; mevalonic acid; mevinolin; oncostatin M; animal cell; article; cell cycle S phase; cell division; cell strain 3T3; controlled study; DNA replication; leukemia; nonhuman; priority journal; protein induction; protein processing; signal transduction
Año:2004
Volumen:313
Número:4
Página de inicio:926
Página de fin:930
DOI: http://dx.doi.org/10.1016/j.bbrc.2003.11.182
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:3 hydroxy 3 methylglutaryl coenzyme A, 1553-55-5; DNA, 9007-49-2; mevalonic acid, 150-97-0; mevinolin, 75330-75-5; oncostatin M, 106956-32-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v313_n4_p926_Sauane

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Citas:

---------- APA ----------
Sauane, M., Coso, O.A., Giulianelli, S., Giráldez, A.N., Rudland, P.S. & Jimenez De Asua, L. (2004) . Leukaemia inhibitory factor or Oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. Biochemical and Biophysical Research Communications, 313(4), 926-930.
http://dx.doi.org/10.1016/j.bbrc.2003.11.182
---------- CHICAGO ----------
Sauane, M., Coso, O.A., Giulianelli, S., Giráldez, A.N., Rudland, P.S., Jimenez De Asua, L. "Leukaemia inhibitory factor or Oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication" . Biochemical and Biophysical Research Communications 313, no. 4 (2004) : 926-930.
http://dx.doi.org/10.1016/j.bbrc.2003.11.182
---------- MLA ----------
Sauane, M., Coso, O.A., Giulianelli, S., Giráldez, A.N., Rudland, P.S., Jimenez De Asua, L. "Leukaemia inhibitory factor or Oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication" . Biochemical and Biophysical Research Communications, vol. 313, no. 4, 2004, pp. 926-930.
http://dx.doi.org/10.1016/j.bbrc.2003.11.182
---------- VANCOUVER ----------
Sauane, M., Coso, O.A., Giulianelli, S., Giráldez, A.N., Rudland, P.S., Jimenez De Asua, L. Leukaemia inhibitory factor or Oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. Biochem. Biophys. Res. Commun. 2004;313(4):926-930.
http://dx.doi.org/10.1016/j.bbrc.2003.11.182