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Meinardi, E.; Florin-Christensen, M.; Paratcha, G.; Azcurra, J.M.; Florin-Christensen, J. "The molecular basis of the self/Non-self selectivity of a coelenterate toxin" (1995) Biochemical and Biophysical Research Communications. 216(1):348-354
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Abstract:

Coelenterates produce potent hemolysins inhibited by sphingomyelin (SM) Remarkably, instead of this lipid, their membrane contain a phosphono analogue of it. Using coelenterolysin (CL), a toxin produced by the sea anemone Phymactis clematis, we have examined a possible connection between these two peculiar traits. Our experiments showed that, while SM binds this lysin and inhibits its hemolytic activity, the endogenous PnSL do neither. In addition, liposomes made of bovine erythrocyte lipids are rapidly disrupted by CL, while those made of P. clematis lipids are completely resistant to it. However, if small amounts of SM are added to the P. clematis lipids, the resulting liposomes become sensitive to CL. Taken together, our results show for the first time that substitution of SM by its phosphono analogue is the molecular basis for the selectivity of an anthozoan toxin. We therefore propose that exotoxin production and membrane composition are coadapted traits that confer on the coelenterates a significant evolutionary advantage. © 1995 Academic Press, Inc.

Registro:

Documento: Artículo
Título:The molecular basis of the self/Non-self selectivity of a coelenterate toxin
Autor:Meinardi, E.; Florin-Christensen, M.; Paratcha, G.; Azcurra, J.M.; Florin-Christensen, J.
Filiación:Department of cell Biology, University of Buenos Aires, Ciudad Universitaria. Pabellon II. 4o Piso., RA-1428 Buenos Aires, Argentina
Institute of Neuroscience(INEUCI), Casilla de Correo 137, RA-1663 San Miguel, Argentina
Año:1995
Volumen:216
Número:1
Página de inicio:348
Página de fin:354
DOI: http://dx.doi.org/10.1006/bbrc.1995.2630
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:BIOCHEM. BIOPHYS. RES. COMMUN.
ISSN:0006291X
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v216_n1_p348_Meinardi

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Citas:

---------- APA ----------
Meinardi, E., Florin-Christensen, M., Paratcha, G., Azcurra, J.M. & Florin-Christensen, J. (1995) . The molecular basis of the self/Non-self selectivity of a coelenterate toxin. Biochemical and Biophysical Research Communications, 216(1), 348-354.
http://dx.doi.org/10.1006/bbrc.1995.2630
---------- CHICAGO ----------
Meinardi, E., Florin-Christensen, M., Paratcha, G., Azcurra, J.M., Florin-Christensen, J. "The molecular basis of the self/Non-self selectivity of a coelenterate toxin" . Biochemical and Biophysical Research Communications 216, no. 1 (1995) : 348-354.
http://dx.doi.org/10.1006/bbrc.1995.2630
---------- MLA ----------
Meinardi, E., Florin-Christensen, M., Paratcha, G., Azcurra, J.M., Florin-Christensen, J. "The molecular basis of the self/Non-self selectivity of a coelenterate toxin" . Biochemical and Biophysical Research Communications, vol. 216, no. 1, 1995, pp. 348-354.
http://dx.doi.org/10.1006/bbrc.1995.2630
---------- VANCOUVER ----------
Meinardi, E., Florin-Christensen, M., Paratcha, G., Azcurra, J.M., Florin-Christensen, J. The molecular basis of the self/Non-self selectivity of a coelenterate toxin. BIOCHEM. BIOPHYS. RES. COMMUN. 1995;216(1):348-354.
http://dx.doi.org/10.1006/bbrc.1995.2630