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Abstract:

Angiotensin II receptors of the AT1 subtype were very highly expressed in medroxyprogesterone-induced ductal adenocarcinomas of the mammary gland in BALB/c mice. AT1 receptors are associated only to neoplastic epithelial cells. Lobular adenocarcinomas expressed very few AT1 receptors and expressed AT2 receptors only in areas corresponding to peritumoral connective tissue. Binding to angiotensin converting enzyme was present in all adenocarcinomas studied and was higher in ductal than in lobular adenocarcinomas. Normal mammary gland did not express either angiotensin II receptors or angiotensin converting enzyme. The present results are the first demonstration of angiotensin receptor subtypes and converting enzyme in mammary adenocarcinomas differentially expressed in tumors of ductal and lobular origin. Localization of receptor subtypes could be useful to study the differentiation of mammary cells during experimental mammary carcinogenesis in mice. © 1993 Academic Press, Inc.

Registro:

Documento: Artículo
Título:Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas
Autor:Guerra, F.K.; Ciuffo, G.M.; Elizalde, P.V.; Charreau, E.H.; Saavedra, J.M.
Filiación:Institute of Biology and Experimental Medicine, Obligado 2490, 1428 Buenos Aires, Argentina
Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, Bldg 10, Room 2D-45, Bethesda, MD 20892, United States
Año:1993
Volumen:193
Número:1
Página de inicio:93
Página de fin:99
DOI: http://dx.doi.org/10.1006/bbrc.1993.1594
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:BIOCHEM. BIOPHYS. RES. COMMUN.
ISSN:0006291X
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v193_n1_p93_Guerra

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Citas:

---------- APA ----------
Guerra, F.K., Ciuffo, G.M., Elizalde, P.V., Charreau, E.H. & Saavedra, J.M. (1993) . Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas. Biochemical and Biophysical Research Communications, 193(1), 93-99.
http://dx.doi.org/10.1006/bbrc.1993.1594
---------- CHICAGO ----------
Guerra, F.K., Ciuffo, G.M., Elizalde, P.V., Charreau, E.H., Saavedra, J.M. "Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas" . Biochemical and Biophysical Research Communications 193, no. 1 (1993) : 93-99.
http://dx.doi.org/10.1006/bbrc.1993.1594
---------- MLA ----------
Guerra, F.K., Ciuffo, G.M., Elizalde, P.V., Charreau, E.H., Saavedra, J.M. "Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas" . Biochemical and Biophysical Research Communications, vol. 193, no. 1, 1993, pp. 93-99.
http://dx.doi.org/10.1006/bbrc.1993.1594
---------- VANCOUVER ----------
Guerra, F.K., Ciuffo, G.M., Elizalde, P.V., Charreau, E.H., Saavedra, J.M. Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas. BIOCHEM. BIOPHYS. RES. COMMUN. 1993;193(1):93-99.
http://dx.doi.org/10.1006/bbrc.1993.1594