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Abstract:

GTP, GTP- γ -S and Gpp(NH)p produced a significant activation of Mg 2+ -dependent adenylyl cyclase in permeabilized cells of Candida albicans. This activation was inhibited by GDP- β -S. Maximal stimulation (4-6 fold) was obtained when Mg 2+ and GTP- γ -S were added during permeabilization. The guanine nucleotide-stimulated activity could be further activated by glucagon in a dose dependent manner being the maximal stimulation (4-5 fold) attained at 10 -6 M glucagon. Addition of the hormone to yeast cells incubated under conditions conducive to produce germ tubes blocked hyphal development and promoted multibudded cell morphology. © 1990.

Registro:

Documento: Artículo
Título:A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology
Autor:Paveto, C.; Egidy, G.; Galvagno, M.A.; Passeron, S.
Filiación:Departamento de Química Biológica y Biología, Facultad de Ciencias Exactas y Naturales (Universidad de Buenos Aires), Pabellón II 40 Piso, Buenos Aires, Argentina
CONICET, Ciudad Universitaria, Pabellón II 40 Piso, Buenos Aires, Argentina
Palabras clave:adenylate cyclase; glucagon; guanosine triphosphate; article; candida albicans; cell structure; fungus; nonhuman; priority journal; Adenylate Cyclase; Candida albicans; Enzyme Activation; Glucagon; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Magnesium; Support, Non-U.S. Gov't; Thionucleotides; Candida albicans; Fungi
Año:1990
Volumen:167
Número:3
Página de inicio:1177
Página de fin:1183
DOI: http://dx.doi.org/10.1016/0006-291X(90)90647-6
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:Adenylate Cyclase, EC 4.6.1.1; Glucagon, 9007-92-5; Guanosine 5'-O-(3-Thiotriphosphate), 37589-80-3; Guanosine Triphosphate, 86-01-1; Guanylyl Imidodiphosphate, 34273-04-6; Magnesium, 7439-95-4; Thionucleotides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v167_n3_p1177_Paveto

Referencias:

  • Romano, (1966) The Fungi, 2, pp. 181-209. , G. Ainsworth, A. Sussman, 5th edition, Academic Press, N.Y.-London
  • Sherr, Weaver, (1953) Bacteriological Rev, 17, pp. 51-92
  • van Brunt, Jumping Phenotypes are Hard to Keep Up With (1987) Bio/Technology, 5, p. 315
  • Egidy, Paveto, Passeron, Galvagno, (1989) Exp. Mycol, 13, pp. 428-432
  • Egidy, Paveto, Passeron, Galvagno, cAMP levels and in situ measurement of cAMP related enzymes during yeast-to-hyphae transition in Candida albicans. (1990) Cell Biol Int Rep, , In press
  • Levitzki, (1988) Trends Biochem. Sci, 13, pp. 298-301
  • Codina, Hildebrandt, Sunyer, Sekura, Manclark, Iyengar, Birnbaumer, (1984) Adv. Cyclic Nucleotide Protein Phosphorylation Res, 17, pp. 111-125
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  • Theibert, Devreotes, (1986) J. Biol. Chem, 261, pp. 15121-15125
  • Gilman, (1987) Annu. Rev. Biochem, 56, pp. 615-649
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  • Flawiá, Torres, (1972) Proc. Natl. Acad. Sci. USA, 69, pp. 2870-2873. , 5th edition

Citas:

---------- APA ----------
Paveto, C., Egidy, G., Galvagno, M.A. & Passeron, S. (1990) . A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology. Biochemical and Biophysical Research Communications, 167(3), 1177-1183.
http://dx.doi.org/10.1016/0006-291X(90)90647-6
---------- CHICAGO ----------
Paveto, C., Egidy, G., Galvagno, M.A., Passeron, S. "A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology" . Biochemical and Biophysical Research Communications 167, no. 3 (1990) : 1177-1183.
http://dx.doi.org/10.1016/0006-291X(90)90647-6
---------- MLA ----------
Paveto, C., Egidy, G., Galvagno, M.A., Passeron, S. "A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology" . Biochemical and Biophysical Research Communications, vol. 167, no. 3, 1990, pp. 1177-1183.
http://dx.doi.org/10.1016/0006-291X(90)90647-6
---------- VANCOUVER ----------
Paveto, C., Egidy, G., Galvagno, M.A., Passeron, S. A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology. Biochem. Biophys. Res. Commun. 1990;167(3):1177-1183.
http://dx.doi.org/10.1016/0006-291X(90)90647-6