Abstract:
The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987.
Registro:
Documento: |
Artículo
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Título: | 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
Autor: | Resnicoff, M.; Medrano, E.E. |
Filiación: | Instituto de Investigaciones Bioquimicas Fundacion Campomar, A. Machado 151, 1405 Buenos Aires, Argentina Facultad de Ciencias Exactas y Naturales (UBA), A. Machado 151, 1405 Buenos Aires, Argentina
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Palabras clave: | growth factor; 13 cis retinal; breast; breast tumor; cell strain mcf 7; dose response; drug mechanism; drug response; growth stimulation; human; human cell; pharmacokinetics; priority journal; protein synthesis; Breast Neoplasms; Cell Division; Cell Line; Cell Nucleus; Female; Human; Kinetics; Neoplasm Proteins; Nucleoproteins; Retinaldehyde; Retinoids; Support, Non-U.S. Gov't |
Año: | 1987
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Volumen: | 143
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Número: | 1
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Página de inicio: | 309
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Página de fin: | 315
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DOI: |
http://dx.doi.org/10.1016/0006-291X(87)90666-8 |
Título revista: | Biochemical and Biophysical Research Communications
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Título revista abreviado: | Biochem. Biophys. Res. Commun.
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ISSN: | 0006291X
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CODEN: | BBRCA
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CAS: | Neoplasm Proteins; Nucleoproteins; Retinaldehyde, 116-31-4; Retinoids
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff |
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Citas:
---------- APA ----------
Resnicoff, M. & Medrano, E.E.
(1987)
. 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7. Biochemical and Biophysical Research Communications, 143(1), 309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8---------- CHICAGO ----------
Resnicoff, M., Medrano, E.E.
"13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7"
. Biochemical and Biophysical Research Communications 143, no. 1
(1987) : 309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8---------- MLA ----------
Resnicoff, M., Medrano, E.E.
"13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7"
. Biochemical and Biophysical Research Communications, vol. 143, no. 1, 1987, pp. 309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8---------- VANCOUVER ----------
Resnicoff, M., Medrano, E.E. 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7. Biochem. Biophys. Res. Commun. 1987;143(1):309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8