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Abstract:

The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987.

Registro:

Documento: Artículo
Título:13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
Autor:Resnicoff, M.; Medrano, E.E.
Filiación:Instituto de Investigaciones Bioquimicas Fundacion Campomar, A. Machado 151, 1405 Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales (UBA), A. Machado 151, 1405 Buenos Aires, Argentina
Palabras clave:growth factor; 13 cis retinal; breast; breast tumor; cell strain mcf 7; dose response; drug mechanism; drug response; growth stimulation; human; human cell; pharmacokinetics; priority journal; protein synthesis; Breast Neoplasms; Cell Division; Cell Line; Cell Nucleus; Female; Human; Kinetics; Neoplasm Proteins; Nucleoproteins; Retinaldehyde; Retinoids; Support, Non-U.S. Gov't
Año:1987
Volumen:143
Número:1
Página de inicio:309
Página de fin:315
DOI: http://dx.doi.org/10.1016/0006-291X(87)90666-8
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:Neoplasm Proteins; Nucleoproteins; Retinaldehyde, 116-31-4; Retinoids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff

Referencias:

  • Jetten, (1984) Federation Proc, 43, p. 143
  • Gold, Metelsman, Moore, Clarckson, (1981) Blood, 58, p. 139
  • Kerr, Lippman, Jenkins, Myers, (1982) Cancer Res, 42, pp. 2069-2073
  • Clamon, Chabot, Valeriote, Davilla, Vogel, Gorowski, Birch, (1985) Cancer Res, 45, pp. 1875-1878
  • Boning, Kakunaga, Emura, Mohr, (1986) Exp. Cell. Res, 163, pp. 255-260
  • Hiragun, Sato, Mitsui, (1983) Exp. Cell. Res, 145, pp. 71-78
  • Jetten, Gilmer, Barrett, (1985) Proceedings of AACR, 26, p. 60
  • Lotan, (1979) Cancer Res, 39, pp. 1014-1019
  • Lacroix, Lippman, Binding of Retinoids to Human Breast Cancer Cell Lines and their Effects on Cell Growth (1981) Journal of Clinical Investigation, 65, pp. 586-591
  • Cassidy, Lippman, Lacroix, Peck, Ozols, (1981) Am. Soc. Clin. Oncol, 22, p. 424
  • Medrano, E.E., Larcher, F., Resnicoff, M. and Cafferata, E.G.A. (1986). Submitted for publication; Lowry, Rosenbrough, Farr, Randall, (1951) J. Biol. Chem, 193, pp. 265-275
  • Mori, Kurabe, Furukawa, Kubo, Hayashi, (1986) Biochem. Biophys. Res. Commun, 136, pp. 300-305
  • Salomon, Zwiebel, Bano, Lsonczy, Fehnnel, Kidwell, (1984) Cancer Res, 44, pp. 4069-4077
  • Keydar, Chen, Karby, Weiss, Delarea, Radu, Chaitcick, Brenner, (1979) Eur. J. Cancer, 15, pp. 659-670
  • Hackett, Smith, Springer, Owens, Nelson-Rees, Riggs, Gardner, (1977) J. Natl. Cancer Inst, 58, pp. 1795-1806
  • Kellermayer, Prestayko, Hazlewood, (1984) Exp. Cell. Res, 152, pp. 255-259
  • Sporn, Roberts, (1983) Cancer Res, 43, pp. 3034-3040
  • Resnicoff, M. and Medrano, E.E. (1986). Manuscript in preparation

Citas:

---------- APA ----------
Resnicoff, M. & Medrano, E.E. (1987) . 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7. Biochemical and Biophysical Research Communications, 143(1), 309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8
---------- CHICAGO ----------
Resnicoff, M., Medrano, E.E. "13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7" . Biochemical and Biophysical Research Communications 143, no. 1 (1987) : 309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8
---------- MLA ----------
Resnicoff, M., Medrano, E.E. "13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7" . Biochemical and Biophysical Research Communications, vol. 143, no. 1, 1987, pp. 309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8
---------- VANCOUVER ----------
Resnicoff, M., Medrano, E.E. 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7. Biochem. Biophys. Res. Commun. 1987;143(1):309-315.
http://dx.doi.org/10.1016/0006-291X(87)90666-8