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Crespi, M.D.; Ivanier, S.E.; Genovese, J.; Baldi, A. "Mitoxantrone affects topoisomerase activities in human breast cancer cells" (1986) Biochemical and Biophysical Research Communications. 136(2):521-528
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Abstract:

The effects of mitoxantrone, an antineoplastic DNA intercalator, on topoisomerase I and II were studied in two human breast cancer cell lines. A large increase of topoisomerase I activity was found when cells were exposed to various doses of mitoxantrone. Maximal effect was achieved with 20 and 40 ng/mL in T47D and MCF-7 cells respectively. The enhancement on topoisomerase I activity seemed to be reversible, to be dependent on time of exposure to the drug and to require cellular integrity. Type II topoisomerase was inhibited in T47D cells after treatment for one hour with 10ng/mL of mitoxantrone and enzyme activity was undetectable at higher doses (40 ng/mL). This inhibitory effect did not take place in vitro unless the concentration of the intercalator was increased to 400-500 ng/mL. © 1986.

Registro:

Documento: Artículo
Título:Mitoxantrone affects topoisomerase activities in human breast cancer cells
Autor:Crespi, M.D.; Ivanier, S.E.; Genovese, J.; Baldi, A.
Filiación:Instituto de Biologia y Medicina Experimental Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:dactinomycin; dna; dna topoisomerase; mitoxantrone; puromycin; breast; breast cancer; cancer chemotherapy; drug cytotoxicity; enzyme inhibition; human; human cell; intoxication; priority journal; therapy; Anthraquinones; Breast Neoplasms; Cell Line; Comparative Study; Dactinomycin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Enzyme Induction; Human; Kinetics; Mitoxantrone; Puromycin; Support, Non-U.S. Gov't
Año:1986
Volumen:136
Número:2
Página de inicio:521
Página de fin:528
DOI: http://dx.doi.org/10.1016/0006-291X(86)90471-7
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; DNA topoisomerase, 80449-01-0; DNA, 9007-49-2; mitoxantrone, 65271-80-9, 70476-82-3; puromycin, 53-79-2, 58-58-2; Anthraquinones; Dactinomycin, 50-76-0; DNA Topoisomerases, Type I, EC 5.99.1.2; DNA Topoisomerases, Type II, EC 5.99.1.3; Doxorubicin, 23214-92-8; Mitoxantrone, 65271-80-9; Puromycin, 53-79-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v136_n2_p521_Crespi

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Citas:

---------- APA ----------
Crespi, M.D., Ivanier, S.E., Genovese, J. & Baldi, A. (1986) . Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochemical and Biophysical Research Communications, 136(2), 521-528.
http://dx.doi.org/10.1016/0006-291X(86)90471-7
---------- CHICAGO ----------
Crespi, M.D., Ivanier, S.E., Genovese, J., Baldi, A. "Mitoxantrone affects topoisomerase activities in human breast cancer cells" . Biochemical and Biophysical Research Communications 136, no. 2 (1986) : 521-528.
http://dx.doi.org/10.1016/0006-291X(86)90471-7
---------- MLA ----------
Crespi, M.D., Ivanier, S.E., Genovese, J., Baldi, A. "Mitoxantrone affects topoisomerase activities in human breast cancer cells" . Biochemical and Biophysical Research Communications, vol. 136, no. 2, 1986, pp. 521-528.
http://dx.doi.org/10.1016/0006-291X(86)90471-7
---------- VANCOUVER ----------
Crespi, M.D., Ivanier, S.E., Genovese, J., Baldi, A. Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem. Biophys. Res. Commun. 1986;136(2):521-528.
http://dx.doi.org/10.1016/0006-291X(86)90471-7