Navegar

Colección

Datos Estadísticas

Artículo

El editor solo permite decargar el artículo en su versión post-print desde el repositorio. Por favor, si usted posee dicha versión, enviela a
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

In the present paper we report evidence about the formation of polyprenyl-phosphate monosaccharides, their elongation products and the assembly of dolichyl-diphosphate-oligosaccharide to endogenous T47D clon 11 proteins upon incubation with [14C]glucose. The influence of estradiol and two nonesteroidal antiestrogens -nafoxidine and tamoxifen- was examined on the dolichol pathway in T47D cell cultures. Estradiol (1 nM) does not change the rate of synthesis of dolichyl-phosphate-sugar derivatives in contrast to nafoxidine and tamoxifen both a micromolar concentration, which induce a remarkable decrease in the formation of dolichol-sugar derivatives. In addition, T47D cells were pretreated with nafoxidine or tamoxifen during one hour, fresh medium supplemented with estradiol was added to the cells simultaneously with [14C]glucose. Results indicated that estradiol after nafoxidine induces a slight increase in the polyprenyl-sugar derivatives formation, however, estradiol after tamoxifen decreases the synthesis of these substances. © 1985.

Registro:

Documento: Artículo
Título:Dolichol-sugar derivative synthesis in human breast cancer cell line (T47D). Effects of estrogens and antiestrogens
Autor:Santa Cruz, A.R.; Medrano, E.E.; Baldi, A.
Filiación:Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Instituto de Investigaciones Bioquimicas Fundacion Campomar Universidad de Buenos Aires, Antonio Machado 151, 1405 Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Antonio Machado 151, 1405 Buenos Aires, Argentina
Palabras clave:antiestrogen; dolichol phosphate; estradiol; estrogen; nafoxidine; radioisotope; tamoxifen; breast; breast cancer; cancer cell; glucosamine h 3; glucose c 14; human; human cell; priority journal; Breast Neoplasms; Cell Line; Chromatography, Ion Exchange; Chromatography, Thin Layer; Estradiol; Female; Human; Nafoxidine; Polyisoprenyl Phosphate Monosaccharides; Polyisoprenyl Phosphate Sugars; Pyrrolidines; Support, Non-U.S. Gov't; Tamoxifen
Año:1985
Volumen:126
Número:1
Página de inicio:382
Página de fin:388
DOI: http://dx.doi.org/10.1016/0006-291X(85)90617-5
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:dolichol phosphate, 12698-55-4, 34457-14-2; estradiol, 50-28-2; nafoxidine, 1845-11-0, 1847-63-8; tamoxifen, 10540-29-1; Estradiol, 50-28-2; Nafoxidine, 1845-11-0; Polyisoprenyl Phosphate Monosaccharides; Polyisoprenyl Phosphate Sugars; Pyrrolidines; Tamoxifen, 10540-29-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v126_n1_p382_SantaCruz

Referencias:

  • Staneloni, Leloir, (1982) CRC Critical Reviews in Biochemistry, 12, pp. 289-326
  • Hubbard, Ivatt, (1981) Ann. Rev. Biochem, 50, pp. 555-583
  • Quesada Allue, Baldi, (1981) IRCS Medical Science, 9, pp. 974-975
  • Santa Cruz, Quesada Allue, Baldi, Lipid-bound sugars in malignant human breast tumors. Partial characterization of mannosyl and glucosyl transferase activities. (1983) Mol Cell Biochem, 56, pp. 55-66
  • Keydar, Chen, Karby, Weiss, Delarea, Radu, Chaitcik, Brenner, (1979) Eur. J. Cancer, 15, pp. 659-670
  • Keydar, I. Personal comunication; Shafie, (1980) Proc. Am. Assoc. Cancer Res, 21, p. 261
  • Ng, Livesey, Larkins, Martin, (1983) Cancer Res, 43, pp. 794-800
  • Folch, Less, Sloane Stanley, (1957) J. Biol. Chem, 226, pp. 497-509
  • Quesada Allue, Belocopitow, (1978) Eur. J. Biochem, 88, pp. 529-541
  • Behrens, Parodi, Leloir, Glucose Transfer from Dolichol Monophosphate Glucose: The Product Formed with Endogenous Microsomal Acceptor (1971) Proceedings of the National Academy of Sciences, 63, pp. 2857-2860
  • Behrens, Carminatti, Staneloni, Leloir, Cantarella, Formation of Lipid-Bound Oligosaccharides Containing Mannose. Their Role in Glycoprotein Synthesis (1973) Proceedings of the National Academy of Sciences, 70, pp. 3390-3394
  • Brett, (1981) Techniques in Carbohydrate Metabolism B, 305, pp. 1-14. , Elsevier/North-Holland Scientific Publishers Ltd
  • Quesada Allue, (1980) Mol. Cell. Biochem, 33, pp. 149-155
  • Lederkremer, Parodi, (1983) J. Chromatography, 262, pp. 299-304
  • Peterson, (1977) Anal. Biochem, 83, pp. 346-356
  • Shuterland, Murphy, Foo, Green, Whybourne, Krozowski, High-affinity anti-oestrogen binding site distinct from the oestrogen receptor (1980) Nature, 288, pp. 273-275
  • Westley, Rochefort, (1980) Cell, 20, pp. 353-362
  • Edwards, Adams, Savage, McGuire, (1980) Biochem. Biophys. Res. Comm, 93, pp. 804-812
  • Ciocca, Adams, Edwards, Bjercke, McGuire, (1983) Cancer Res, 43, pp. 1204-1210
  • Sirbasku, (1978) Cancer Res, 43, pp. 1204-1210
  • Lucas, Levin, (1977) J. Biol. Chem, 252, pp. 4330-4336
  • Ramachandran, Gray, Melnykovych, (1982) Biochem. J, 208, pp. 47-52
  • Strobl, Lippman, (1978) Hormones, Receptors, and Breast Cancer, pp. 85-106. , Raven Press, New York
  • Miller, Katzenellenbogen, (1983) Cancer Res, 43, pp. 3094-3100

Citas:

---------- APA ----------
Santa Cruz, A.R., Medrano, E.E. & Baldi, A. (1985) . Dolichol-sugar derivative synthesis in human breast cancer cell line (T47D). Effects of estrogens and antiestrogens. Biochemical and Biophysical Research Communications, 126(1), 382-388.
http://dx.doi.org/10.1016/0006-291X(85)90617-5
---------- CHICAGO ----------
Santa Cruz, A.R., Medrano, E.E., Baldi, A. "Dolichol-sugar derivative synthesis in human breast cancer cell line (T47D). Effects of estrogens and antiestrogens" . Biochemical and Biophysical Research Communications 126, no. 1 (1985) : 382-388.
http://dx.doi.org/10.1016/0006-291X(85)90617-5
---------- MLA ----------
Santa Cruz, A.R., Medrano, E.E., Baldi, A. "Dolichol-sugar derivative synthesis in human breast cancer cell line (T47D). Effects of estrogens and antiestrogens" . Biochemical and Biophysical Research Communications, vol. 126, no. 1, 1985, pp. 382-388.
http://dx.doi.org/10.1016/0006-291X(85)90617-5
---------- VANCOUVER ----------
Santa Cruz, A.R., Medrano, E.E., Baldi, A. Dolichol-sugar derivative synthesis in human breast cancer cell line (T47D). Effects of estrogens and antiestrogens. Biochem. Biophys. Res. Commun. 1985;126(1):382-388.
http://dx.doi.org/10.1016/0006-291X(85)90617-5