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Speziale, E.; Speziale, N.; Lugo, S.; Gimeno, M. "Rat renal medulla possess high capacity to catabolize prostaglandins" (1984) Biochemical and Biophysical Research Communications. 124(1):69-74
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Abstract:

Prostaglandin E2 is converted to 15-keto-13,14 dihydro prostaglandin E2, 15-keto-prostaglandin F2α and 15-keto-13,14 dihydro prostaglandin F2α, by supernatants from rat kidney medulls. The main pathway for prostaglandin E2 inactivation is the combined action of 15 hydroxy dehydrogenase and Δ13 reductase enzymes. 9-Keto-reductase route constitutes a minor pathway. Prostaglandin F2α is converted into 15-keto-prostaglandin F2α, 15-keto-13,14 dihydro prostaglandin F2α and 15-keto-dihydro prostaglandin E2. Enzyme activities are time and substrate-concentration dependent. In the presence of an excess of substrate, rat renal medulls inactivates 40 and 56 times more prostaglandin E2 and prostaglandin F2α, respectively, than the amount which is released under basal conditions. These results are in contrast to the generally accepted concept that the kidney cortex is the sole site of renal prostaglandin catabolism, and suggest, for the first time, that rat renal medulls may be a key site for the modulation of prostaglandin levels in the kidney. © 1984.

Registro:

Documento: Artículo
Título:Rat renal medulla possess high capacity to catabolize prostaglandins
Autor:Speziale, E.; Speziale, N.; Lugo, S.; Gimeno, M.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN) Serrano 665/669., 1414 Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Serrano 665/669., 1414 Buenos Aires, Argentina
Palabras clave:prostaglandin; 15 hydroxysteroid dehydrogenase; 9 ketoreductase; animal cell; kidney; kidney medulla; nonhuman; priority journal; rat; Animal; Carbon Radioisotopes; Dinoprost; Dinoprostone; Kidney Medulla; Kinetics; Prostaglandin-Endoperoxide Synthase; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Support, Non-U.S. Gov't
Año:1984
Volumen:124
Número:1
Página de inicio:69
Página de fin:74
DOI: http://dx.doi.org/10.1016/0006-291X(84)90917-3
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:Carbon Radioisotopes; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Prostaglandin-Endoperoxide Synthase, EC 1.14.99.1; Prostaglandins E; Prostaglandins F; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v124_n1_p69_Speziale

Referencias:

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Citas:

---------- APA ----------
Speziale, E., Speziale, N., Lugo, S. & Gimeno, M. (1984) . Rat renal medulla possess high capacity to catabolize prostaglandins. Biochemical and Biophysical Research Communications, 124(1), 69-74.
http://dx.doi.org/10.1016/0006-291X(84)90917-3
---------- CHICAGO ----------
Speziale, E., Speziale, N., Lugo, S., Gimeno, M. "Rat renal medulla possess high capacity to catabolize prostaglandins" . Biochemical and Biophysical Research Communications 124, no. 1 (1984) : 69-74.
http://dx.doi.org/10.1016/0006-291X(84)90917-3
---------- MLA ----------
Speziale, E., Speziale, N., Lugo, S., Gimeno, M. "Rat renal medulla possess high capacity to catabolize prostaglandins" . Biochemical and Biophysical Research Communications, vol. 124, no. 1, 1984, pp. 69-74.
http://dx.doi.org/10.1016/0006-291X(84)90917-3
---------- VANCOUVER ----------
Speziale, E., Speziale, N., Lugo, S., Gimeno, M. Rat renal medulla possess high capacity to catabolize prostaglandins. Biochem. Biophys. Res. Commun. 1984;124(1):69-74.
http://dx.doi.org/10.1016/0006-291X(84)90917-3