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Abstract:

The secretion of interleukin 2 (IL-2) is a key event in T cell activation. IL-2 allows T cells to enter into the S phase of the cell cycle and divide. After the activation phase takes place, T lymphocytes proliferate and differentiate to generate effector T cells. Thereby, T helper (Th) precursor cells, which are functionally immature, may become Th1 or Th2 effector cells. These subsets are responsible for cell-mediated immunity and humoral responses, respectively. Both T cell activation and Th differentiation are processes that depend on changes in the pattern of gene expression. The expression and changes in the genes responsible for these events are regulated by transcription factors. This review will focus on both the transcription factors involved in the control of IL-2 as well as those that are key to T helper differentiation.

Registro:

Documento: Artículo
Título:Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation
Autor:Liberman, A.C.; Refojo, D.; Arzt, E.
Filiación:Lab. of Physiol. and Molec. Biology, Dept. of Physiol./Molec./Cell. Biol., Buenos Aires University, Buenos Aires, Argentina
Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:GATA-3; IL-2; T cell activation; T cell differentiation; T-bet; TCR; binding protein; CD28 antigen; cytokine; gamma interferon; glucocorticoid; immunoglobulin enhancer binding protein; interleukin 12; interleukin 2; interleukin 4; interleukin 5; leucine zipper protein; messenger RNA; STAT protein; T lymphocyte receptor; transcription factor; transcription factor GATA 3; transcription factor NFAT; cell cycle; cell division; cellular immunity; clone; effector cell; gene expression; humoral immunity; lymphocyte differentiation; lymphocyte proliferation; nonhuman; precursor; review; signal transduction; T lymphocyte activation; Th1 cell; Th2 cell; transcription regulation; Animals; Cell Differentiation; Gene Expression Regulation; Humans; Interleukin-2; Lymphocyte Activation; Signal Transduction; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells; Transcription Factors
Año:2003
Volumen:51
Número:6
Página de inicio:351
Página de fin:365
Título revista:Archivum Immunologiae et Therapiae Experimentalis
Título revista abreviado:Arch. Immunol. Ther. Exp.
ISSN:0004069X
CODEN:AITEA
CAS:gamma interferon, 82115-62-6; interleukin 12, 138415-13-1; interleukin 2, 85898-30-2; transcription factor GATA 3, 137878-55-8; transcription factor NFAT, 292890-46-1; Interleukin-2; Transcription Factors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0004069X_v51_n6_p351_Liberman

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Citas:

---------- APA ----------
Liberman, A.C., Refojo, D. & Arzt, E. (2003) . Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation. Archivum Immunologiae et Therapiae Experimentalis, 51(6), 351-365.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0004069X_v51_n6_p351_Liberman [ ]
---------- CHICAGO ----------
Liberman, A.C., Refojo, D., Arzt, E. "Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation" . Archivum Immunologiae et Therapiae Experimentalis 51, no. 6 (2003) : 351-365.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0004069X_v51_n6_p351_Liberman [ ]
---------- MLA ----------
Liberman, A.C., Refojo, D., Arzt, E. "Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation" . Archivum Immunologiae et Therapiae Experimentalis, vol. 51, no. 6, 2003, pp. 351-365.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0004069X_v51_n6_p351_Liberman [ ]
---------- VANCOUVER ----------
Liberman, A.C., Refojo, D., Arzt, E. Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation. Arch. Immunol. Ther. Exp. 2003;51(6):351-365.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0004069X_v51_n6_p351_Liberman [ ]