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Heber, E.M.; Trivillin, V.A.; Nigg, D.W.; Itoiz, M.E.; Gonzalez, B.N.; Rebagliati, R.J.; Batistoni, D.; Kreimann, E.L.; Schwint, A.E. "Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model" (2006) Archives of Oral Biology. 51(10):922-929
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Abstract:

Objective: BNCT is a tumour cell targeted radiation therapy. Uniform targeting of heterogeneous tumours with therapeutically effective boron carriers would contribute to a therapeutic effect on all tumour cell populations and avoid radioresistant fractions. This remains an unresolved challenge. The aim of the present study was to evaluate the degree of variation in boron content delivered by boronophenylalanine (BPA), GB-10 (Na210B10H10) and the combined administration of (BPA + GB-10) in different portions of tumour, precancerous tissue around tumour and normal pouch tissue in the hamster cheek pouch oral cancer model. Materials and methods: Samples of different areas of tumour, precancerous tissue and normal pouch tissue were taken from tumour-bearing hamsters, 3 h post-administration of i.p. BPA (15.5 mg B/kg b.w.), or i.v. GB-10 (50 mg B/kg b.w.), or 3 h and 1.5 h post-administration respectively of i.v. GB-10 (34.5 mg B/b.w.) and sequential i.p. injections of BPA (total dose 31 mg B/kg b.w.) given jointly. Boron content was evaluated by inductively coupled plasma optical emission spectroscopy (ICP-OES). The degree of homogeneity in boron targeting was assessed in terms of the coefficient of variation (V: [S.D./mean] × 100) of boron values. Statistical analysis of the results was performed by one-way ANOVA and the least significant difference test. Results: GB-10 and GB-10 plus BPA achieved respectively a statistically significant 1.8- and 3.3-fold increase in targeting homogeneity over BPA. Conclusions: The combined boron compound administration protocol contributes to homogeneous targeting of heterogeneous tumours and would be expected to increase therapeutic efficacy of BNCT. © 2006 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model
Autor:Heber, E.M.; Trivillin, V.A.; Nigg, D.W.; Itoiz, M.E.; Gonzalez, B.N.; Rebagliati, R.J.; Batistoni, D.; Kreimann, E.L.; Schwint, A.E.
Filiación:Department of Radiobiology, National Atomic Energy Commission, Av. General Paz 1499, B1650KNA San Martin, Argentina
Idaho National Laboratory, 2525 North Fremont Street, Idaho Falls, ID 83415, United States
Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Marcelo T. de Alvear 2142, 1122 Buenos Aires, Argentina
Biometry Division, Department of Ecology, Genetics and Evolution, Faculty of Exact and Natural Sciences, Ciudad Universitaria, 1428 Nuñez Buenos Aires, Argentina
Department of Chemistry, National Atomic Energy Commission, Av. General Paz 1499, B1650KNA San Martin, Argentina
Palabras clave:BNCT; Boron targeting; Hamster cheek pouch; Oral cancer; 4 dihydroxyborylphenylalanine; 4-dihydroxyborylphenylalanine; 7,12 dimethylbenz[a]anthracene; borane derivative; boron derivative; drug derivative; phenylalanine; animal; article; cheek; chemically induced disorder; disease model; hamster; metabolism; methodology; mouth mucosa; mouth tumor; neutron capture therapy; precancer; Syrian hamster; 9,10-Dimethyl-1,2-benzanthracene; Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Disease Models, Animal; Mesocricetus; Mouth Mucosa; Mouth Neoplasms; Phenylalanine; Precancerous Conditions; Cricetinae
Año:2006
Volumen:51
Número:10
Página de inicio:922
Página de fin:929
DOI: http://dx.doi.org/10.1016/j.archoralbio.2006.03.015
Título revista:Archives of Oral Biology
Título revista abreviado:Arch. Oral Biol.
ISSN:00039969
CODEN:AOBIA
CAS:7,12 dimethylbenz[a]anthracene, 57-97-6; phenylalanine, 3617-44-5, 63-91-2; 4-dihydroxyborylphenylalanine; 9,10-Dimethyl-1,2-benzanthracene, 57-97-6; Borohydrides; Boron Compounds; Phenylalanine, 63-91-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039969_v51_n10_p922_Heber

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Citas:

---------- APA ----------
Heber, E.M., Trivillin, V.A., Nigg, D.W., Itoiz, M.E., Gonzalez, B.N., Rebagliati, R.J., Batistoni, D.,..., Schwint, A.E. (2006) . Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model. Archives of Oral Biology, 51(10), 922-929.
http://dx.doi.org/10.1016/j.archoralbio.2006.03.015
---------- CHICAGO ----------
Heber, E.M., Trivillin, V.A., Nigg, D.W., Itoiz, M.E., Gonzalez, B.N., Rebagliati, R.J., et al. "Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model" . Archives of Oral Biology 51, no. 10 (2006) : 922-929.
http://dx.doi.org/10.1016/j.archoralbio.2006.03.015
---------- MLA ----------
Heber, E.M., Trivillin, V.A., Nigg, D.W., Itoiz, M.E., Gonzalez, B.N., Rebagliati, R.J., et al. "Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model" . Archives of Oral Biology, vol. 51, no. 10, 2006, pp. 922-929.
http://dx.doi.org/10.1016/j.archoralbio.2006.03.015
---------- VANCOUVER ----------
Heber, E.M., Trivillin, V.A., Nigg, D.W., Itoiz, M.E., Gonzalez, B.N., Rebagliati, R.J., et al. Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model. Arch. Oral Biol. 2006;51(10):922-929.
http://dx.doi.org/10.1016/j.archoralbio.2006.03.015