Artículo
Abstract:
The epididymal portion of the rat vas deferens from normal and castrated rats exhibited clear differences regarding both the threshold and the maximal response to acetylcholine. Alpha adrenoceptor antagonists, hexamethonium and 6-hydroxydopamine diminished the effectiveness of low acetylcholine concentrations on normal and castrated preparations of the epididymal portion of isolated rat vas deferens, but did not influence the maximal response. On the other hand, desipramine enhanced the action of low concentrations of acetylcholine, both in threshold and maximal response, but failed to alter the reactivity to high concentrations of acetylcholine. The results obtained suggest that low doses of acetylcholine may affect the contractile function of the isolated epididymal portion of rat vas deferens by producing a release of norepinephrine from presynaptic sites and act in a similar fashion on preparations from both normal and castrated animals.
Registro:
| Documento: | Artículo |
| Título: | Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms |
| Autor: | Del Agostini, C.M.; Borda, E.S.; Gimeno, M.F.; Gimeno, A.L. |
| Filiación: | Cent. Estud. Farmacol. Principios Nat., CEFAPRIN, Consejo Nac. Invest. Cient. Tecn. Republ. Argentina, CONICET, 1428 Buenos Aires, Argentina |
| Palabras clave: | acetylcholine; desipramine; hexamethonium; oxidopamine; phenoxybenzamine; phentolamine; animal experiment; castration; controlled study; drug response; male genital system; rat; smooth muscle contractility; vas deferens; Acetylcholine; Adrenergic alpha-Antagonists; Animal; Castration; Comparative Study; In Vitro; Male; Muscle Contraction; Norepinephrine; Rats; Receptors, Adrenergic; Support, Non-U.S. Gov't; Testis; Vas Deferens |
| Año: | 1981 |
| Volumen: | 250 |
| Número: | 2 |
| Página de inicio: | 212 |
| Página de fin: | 220 |
| Título revista: | Archives Internationales de Pharmacodynamie et de Therapie |
| Título revista abreviado: | ARCH. INT. PHARMACODYN. THER. |
| ISSN: | 00039780 |
| CODEN: | AIPTA |
| CAS: | acetylcholine, 51-84-3, 60-31-1, 66-23-9; desipramine, 50-47-5, 58-28-6; hexamethonium, 60-26-4; oxidopamine, 1199-18-4, 28094-15-7, 636-00-0; phenoxybenzamine, 59-96-1, 63-92-3; phentolamine, 50-60-2, 73-05-2; Acetylcholine, 51-84-3; Adrenergic alpha-Antagonists; Norepinephrine, 51-41-2; Receptors, Adrenergic |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini |
Citas:
---------- APA ----------
Del Agostini, C.M., Borda, E.S., Gimeno, M.F. & Gimeno, A.L. (1981) . Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms. Archives Internationales de Pharmacodynamie et de Therapie, 250(2), 212-220.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini [ ]
---------- CHICAGO ----------
Del Agostini, C.M., Borda, E.S., Gimeno, M.F., Gimeno, A.L. "Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms" . Archives Internationales de Pharmacodynamie et de Therapie 250, no. 2 (1981) : 212-220.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini [ ]
---------- MLA ----------
Del Agostini, C.M., Borda, E.S., Gimeno, M.F., Gimeno, A.L. "Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms" . Archives Internationales de Pharmacodynamie et de Therapie, vol. 250, no. 2, 1981, pp. 212-220.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini [ ]
---------- VANCOUVER ----------
Del Agostini, C.M., Borda, E.S., Gimeno, M.F., Gimeno, A.L. Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms. ARCH. INT. PHARMACODYN. THER. 1981;250(2):212-220.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini [ ]
