The effect of glomerulopressin on the increase of the contractile tension developed by isolated strips of stomach fundus, duodenum and bladder of rats, was investigated. Glomerulopressin is a glucuronide whose contractile inducing effect was destroyed by β-glucuronidase. It was observed that glomerulopressin increases the contractile tension of these tissues, and that this action was not blocked by atropine, cyproheptadine, tranylcypromine, but was inhibited by indomethacin, suggesting that the effect of glomerulopressin action was mediated by prostaglandin release.
Documento: | Artículo |
Título: | Action of glomerulopressin on smooth muscle contraction, probably mediated by the release of prostaglandins |
Autor: | Uranga, J.; Del Castillo, E.; Gimeno, M. |
Filiación: | Inst. Biol. Med. Exp., 1428 Buenos Aires, Argentina |
Palabras clave: | atropine; beta glucuronidase; cyproheptadine; indometacin; prostaglandin; tranylcypromine; animal experiment; bladder; drug comparison; drug interaction; drug response; duodenum; endocrine system; glomerulopressin; in vitro study; kidney; muscle; rat; small intestine; smooth muscle tone; stomach; Animal; Bladder; Dogs; Drug Interactions; Duodenum; Glucuronates; Hormones; In Vitro; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins; Rats; Stomach; Tranylcypromine |
Año: | 1979 |
Volumen: | 238 |
Número: | 1 |
Página de inicio: | 19 |
Página de fin: | 27 |
Título revista: | Archives Internationales de Pharmacodynamie et de Therapie |
Título revista abreviado: | ARCH. INT. PHARMACODYN. THER. |
ISSN: | 00039780 |
CODEN: | AIPTA |
CAS: | atropine, 51-55-8, 55-48-1; beta glucuronidase, 9001-45-0; cyproheptadine, 129-03-3, 969-33-5; indometacin, 53-86-1, 74252-25-8, 7681-54-1; tranylcypromine, 13492-01-8, 155-09-9, 54-97-7; Glucuronates; Hormones; Prostaglandins; Tranylcypromine, 155-09-9 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v238_n1_p19_Uranga |